Abstract
Neurochemical and pharmacological evidence has been obtained that noradrenergic varicosities (in mouse and rat vas deferens) and cholinergic varicosities (in the Auerbach's plexus) contain heterogenous alpha2-adrenoceptors through which the release of [3H]noradrenaline and [3H]acetylcholine can be modulated. The quantitative data also support the hypothesis that different noradrenaline and xylazine sensitive alpha2-adrenoceptors are present prejunctionally in the vas deferens and Auerbach's plexus preparations. Prazosin, although it has a presynaptic inhibitory effect on alpha2-adrenoceptors of noradrenergic axon terminals, has no effect on cholinergic axon terminals. These data suggest that there are two different types of alpha2-adrenoceptors at the presynaptic axon terminals.
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Kapocsi, J., Somogyi, G.T., Ludvig, N. et al. Neurochemical evidence for two types of presynaptic alpha2-adrenoceptors. Neurochem Res 12, 141–147 (1987). https://doi.org/10.1007/BF00979530
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DOI: https://doi.org/10.1007/BF00979530