Abstract
The tympanic membrane was perforated (n = 19) or a tube was inserted into the middle ear through the wall of the tympanic bulla (n = 6) immediately after blockage of the endolymphatic duct in guinea pigs. Total cochlear endolymph volume and volumes in each cochlear turn were determined from serial sections of the temporal bones and volume changes were analyzed statistically by comparison with hydropic controls without treatment (n = 12). Results showed that both middle ear ventilation procedures significantly reduced the subsequent development of endolymphatic hydrops. This inhibition of hydrops was presumed to be due to pressure release into the middle ear and/or improved oxygenation of the middle and inner ears. Findings suggest the possible merit of a tympanostomy as a treatment for Meniere's disease in carefully selected patients refractory to medical management.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Cantekin EI, Doyle WJ, Phillips DC, Bluestone CD (1980) Gas absorption in the middle ear. Ann Otol Rhinol Laryngol [Suppl] 68:71–75
Cazals Y, Wu Z, Horner KC (1992) Effects of hypoxia at 5% oxygen on global electrophysiological responses from normal and hydropic ears of awake guinea pigs. J Phys IV 2 [Suppl 11i]:253–256
Cinnamond MJ (1975) Eustachian tube function in Meniere's disease. J Laryngol Otol 89:57–61
Densert B (1987) Effects of overpressure on hearing function in Meniere's disease. Acta Otolaryngol (Stockh) 103:32–42
Fattori B, Ghilardi PL, Casani A, De Ciccio M, Vannucci G, De Iaco G (1994) Hyperbaric oxygenation therapy in Meniere's disease. In: Filipo R, Barbara M (eds) Meniere's disease: perspectives in the 90's. Kugler, Amsterdam, pp 493–496
Grøntved A, Møller Å, Jørgensen L (1990) Studies on gas tension in the normal middle ear. Acta Otolaryngol (Stockh) 109: 271–277
Hall M, Brackmann DE (1977) Eustachian tube blockage and Meniere's disease. Arch Otolaryngol 103:355–357
Hergils L, Magnuson B (1987) Middle ear pressure under basal conditions. Arch Otolaryngol Head Neck Surg 113:829–832
Hergils L, Magnuson B (1990) Human middle ear gas composition studied by mass spectrometry. Acta Otolaryngol (Stockh) 110:92–99
Hsu CJ, Kimura RS (1989) Activity of cytochrome oxidase in normal and pathologic inner ears of guinea pigs. ARO Abstr 152
Ichimiya I, Adams JC, Kimura RS (1994) Changes in immunostaining of cochleas with experimentally induced endolymphatic hydrops. Ann Otol Rhinol Laryngol 103:457–468
Ikeda K, Kusakari J, Takasaka T, Saito Y (1987) The Ca2+ activity of cochlear endolymph of the guinea pig and the effect of inhibitors. Hear Res 26:117–125
Ingelstedt S, Jonson B, Rundcrantz H (1975) Gas tension and pH in middle ear effusion. Ann Otol Rhinol Laryngol 84:198–202
Kimura RS (1967) Experimental blockage of the endolymphatic duct and sac and its effect on the inner ear of the guinea pig. Ann Otol Rhinol Laryngol 76:664–687
Kimura RS, Schuknecht HF (1965) Membranous hydrops in the inner ear of the guinea pig after obliteration of the endolymphatic sac. Pract Otorhinolaryngol 27:343–354
Lall M (1969) Meniere's disease and the grommet (a survey of its therapeutic effects). J Laryngol Otol 83:787–791
Merica FW (1942) Vertigo due to obstruction of the eustachian tubes. JAMA 118:1282–1284
Montandon P, Guillemin P, Häusler R (1988) Prevention of vertigo in Meniere's syndrome by means of transtympanic ventilation tubes. ORL 50:377–381
Morgenstern C, Kessler M (1978) Oxygen consumption and oxygen distribution in the inner car. Arch Otorhinolaryngol 220:159–162
Morgenstern C, Kessler M (1980) Local oxygen supply of the mucosa of middle ear under normal conditions and after occlusion of the eustachian tube. In: Munker G, Arnold W (eds) Physiology and pathophysiology of eustachian tube and middle ear. Thieme, Stuttgart, pp 174–178
Morizono T, Hoehmann D (1987) Oxygen concentration in the inner ear fluids with otitis media. In: Sadé J (ed) The eustachian tube. Kugler, Amsterdam, pp 99–105
Nakashima T, Watanabe Y, Yanagita N (1987) The effect of round window membrane rupture on endolymphatic and perilymphatic pressures. Arch Otorhinolaryngol 244:236–240
Ninoyu O, Meyer zum Gottesberge AM (1986) Changes in Ca2+ activity and DC potential in experimentally induced endolymphatic hydrops. Arch Otorhinolaryngol 243:106–107
Nishihara S, Gyo K, Yanagihara N (1992) Transmission of change in the atmospheric pressure of the external ear to the perilymph. Am J Otol 13:364–368
Ohmura M, Satoh H, Honjo I, (1987) Influence of altered middle ear pressure on cochlear microphonics. Acta Otolaryngol (Stockh) 104:255–260
Proud GO, Odoi H, Toledo PS (1971) Bullar pressure changes in eustachian tube dysfunction. Ann Otol Rhinol Laryngol 80:835–837
Sadé J, Luntz M (1991) Gas diffusion in the middle ear. Acta Otolaryngol (Stockh) 111:354–357
Sakikawa Y, Wall C III, Kimura RS (1996) The effects of middle ear pressure on normal and hydropic ears of the guinea pig. ARO Abstr 332
Salt AN, DeMott J (1994) Endolymph calcium increases with time after surgical induction of hydrops in guinea-pigs. Hear Res 74:115–121
Segal J, Ostfeld E, Yinon J, Silberberg A, Sadé J (1984) Mass spectrometric analysis of gas composition in the guinea pig middle ear-mastoid system. In: Lim DJ, Bluestone CD, Klein JO, Nelson JD (eds) Recent advances in otitis media with effusion. Decker, Philadelphia and Mosby, St Louis, pp 68–70
Shinkawa H, Okitsu T, Yusa T, Yamamuro M, Kaneko Y (1987) Positive intratympanic pressure in the morning and its etiology. Acta Otolaryngol (Stockh) [Suppl] 435:107–111
Suzuki M, Kitahara M, Kitano H (1994) The influence of middle ear pressure changes on the primary vestibular neurons in guinea pigs. Acta Otolaryngol (Stockh) [Suppl] 510:9–15
Tumarkin A (1966) Thoughts on the treatment of labyrinthopathy. J Laryngol Otol 80:1041–1053
Yoshida M, Lowry LD (1984) Hydrostatic pressure measurement of endolymph and perilymph in the guinea pig cochlea. Am J Otolaryngol 5:159–165
Yufu K, Itoh T, Edamatsu R, Akitane M, Hirakawa M (1993) Effect of hyperbaric oxygenation on the Na+, K+-ATPase and membrane fluidity of cerebrocortical membranes after experimental subarachnoid hemorrhage. Neurochem Res 18:1033–1039
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kimura, R.S., Hutta, J. Inhibition of experimentally induced endolymphatic hydrops by middle ear ventilation. Eur Arch Otorhinolaryngol 254, 213–218 (1997). https://doi.org/10.1007/BF00874091
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00874091