Summary
The distribution of i.v. injected109Cd within the nervous system was studied in rats 24 h and 1 week after the injection. Measurements by gamma scintillation showed a high uptake of cadmium in peripheral sensory and autonomic ganglia, whereas the uptake was low in the brain, cerebellum, and spinal cord. The accumulation of cadmium in the sciatic nerve was significantly higher than in the brain and spinal nerve roots, but lower than in ganglia.
At autoradiography no labeling was seen in the major part of the brain parenchyma, but an accumulation of the metal was observed in structures outside of the blood-brain barrier (BBB), such as the hypophysis, meninges, choroid plexus and pineal gland. Within the peripheral nervous system (PNS), autoradiography showed accumulation of cadmium in the dorsal root ganglia.
The results show that the distribution of109Cd within the nervous system is correlated to regional variations in vascular permeability, blood vessels of different regions permitting penetration of different amounts of the protein-bound cadmium into the nervous tissues. The accumulation of cadmium in certain nervous structures may have relevance for some of the neurotoxicologic effects of this metal that have been demonstrated in animal experiments.
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References
Adams RG, Crabtree N (1961) Anosmia in alkaline battery workers. J Industr Med 18:216–221
Arvidson B (1977) Cellular uptake of exogenous horseradish peroxidase in mouse peripheral nerve. Acta Neuropathol (Berl) 26:199–205
Arvidson B (1979) Distribution of intravenously injected protein tracers in peripheral ganglia of adult mice. Exp Neurol 63:388–410
Arvidson B (1983) Cadmium toxicity and neural cell damage. In: Dreosti IE, Smith RM (eds) Neurobiology of the trace elements Humana Press. Clifton, pp 51–78
Arvidson B (1984) Evidence for vesicular transport of horseradish peroxidase across endoneurial vessels of the sciatic nerve in normal mice. Acta Neuropathol (Berl) 64:1–5
Arvidson B, Kristensson K, Olsson Y (1973) Vascular permeability to fluorescent protein tracer in trigeminal nerve and Gasserian ganglion. Acta Neuropathol (Berl) 26:199–205
Baader EW (1952) Chronic cadmium poisoning. Ind Med Surg 21:427–430
Berlin M, Ullberg S (1963) The fate of Cd109 in the mouse. AMA Arch Environ Health 7:686–691
Bradbury MWB, Crowder J (1976) Compartments and barriers in the sciatic nerve of the rabbit. Brain Res 103:515–526
Buhler DR, Wright DC, Smith KC, Tinsley IJ (1981) Cadmium absorption and tissue distribution in rats provided low concentrations of cadmium in food or drinking water. J Toxicol Environ Health 8:185–197
Cahill AL, Nyberg D, Ehret CF (1983) Tissue distribution of cadmium and metallothionein as a function of time of day and dosage. Environ Res 31:54–65
Chen RW, Whanger PD, Weshig PH (1975) Selenium-induced redistribution of cadmium binding to tissue proteins: A possible mechanism of protection against cadmium toxicity. Bioinorg Chem 4:125–133
Fassett DW (1975) Cadmium: Biological effects and occurrence in the environment. Ann Rev Pharmacol 15:425–435
Friberg L (1950) Health hazards in the manufacture of alkaline accumulators with special reference to chronic cadmium poisoning. Acta Med Scand 138:Suppl 240
Friberg L, Piscator M, Nordberg GF, Kjellström T (1974) Cadmium in the Environment. CRC Press Inc. Cleveland
Gabbiani G (1966) Action of cadmium chloride on sensory ganglia. Experientia 22:261–262
Gabbiani G, Baic O, Deziel C (1967) Toxicity of cadmium for the central nervous system. Exp Neurol 18:154–160
Gasiewicz TA, Smith JC (1976) Interactions of cadmium and selenium in rat plasma in vivo and in vitro. Biochim Biophys Acta 428:113–122
Jacobs JM, MacFarlane RM, Cavanagh JB (1976) Vascular leakage in the dorsal root ganglia of the rat, studied with horseradish peroxidase. J Neurol Sci 29:95–107
Malmgren LT, Olsson Y (1980) Differences between the peripheral and the central nervous system in permeability to sodium fluorescein. J Comp Neurol 191:103–117
Nordberg GF (1972) Cadmium metabolism and toxicity. Environ Physiol Biochem 2:7–36
Nordberg GF, Nishiyama K (1972) Whole-body and hair retention of cadmium in mice. Acta Environ Health 24:209–214
Olsson Y (1971) Studies on vascular permeability in peripheral nerves. IV. Distribution of intravenously injected protein tracers in the peripheral nervous system of various species. Acta Neuropathol (Berl) 16:101–116
Rapoport SI (1976) Blood brain barrier in physiology and medicine Raven Press, New York
Rastogi RB, Merali Z, Singhal RL (1977) Cadmium alters behaviour and the biosynthetic capacity for catecholamines and serotonin in neonatal rat brain. J Neurochem 28:789–794
Reese TS, Karnovsky MJ (1967) Fine structural localization of a blood-brain barrier to exogenous peroxidase. J Cell Biol 14:189–192
Sato K, Iwamasa T, Tsuru T, Takeuchi T (1978) An ultrastructural study of chronic cadmium chloride induced neuropathy. Acta Neuropathol (Berl) 41:185–190
Squibb RE, Squibb RL (1979) Effect of food toxicants on voluntary wheel running in rats. J Nutr 109:767–772
Tischner KH, Schröder JM (1972) The effects of cadmium chloride on organotypic cultures of rat sensory ganglia. J Neurol Sci 16:383–399
Ullberg S (1954) Studies on the distribution and fate of35S-labelled benzyl penicillin in the body. Acta Radiol [Suppl] 118:1–110
Ullberg S (1977) The technique of whole body autoradiography. Cryosectioning of large specimens. Sci Tools 2:2–29
Vorobjeva RS (1975) Investigations of the nervous system function in workers exposed to cadmium oxide. In Neuropat Psikhiat 57:385–393
Walsh JJ, Burch GE (1959) The rate of disappearance from plasma and subsequent distribution of radiocadmium (115mCd) in normal dogs. J Lab Clin Med 54:59–65
Webster WA, Valois AA (1981) The toxic effects of cadmium on the neonatal mouse CNS. J Neuropathol Exp Neurol 40:247–257
Wong K-L, Klaassen CD (1982) Neurotoxic effects of cadmium in yound rats. Toxicol Appl Pharmacol 63:330–337
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Supported by grants from the Swedish Society of Medical Sciences and the Swedish Medical Research Council (project no. B86-12X-07472-01A
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Arvidson, B., Tjälve, H. Distribution of109Cd in the nervous system of rats after intravenous injection. Acta Neuropathol 69, 111–116 (1986). https://doi.org/10.1007/BF00687046
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DOI: https://doi.org/10.1007/BF00687046