Summary
The epiphenomena that seem to cause deterioration and death after spontaneous interacerebral hematoma (SICH) might best be studied in an animal model. Therefore, the principles for developing such a model and techniques to study these phenomena were evaluated. Animals will tolerate injection of 3%–5% of their brain volume with a high proportion of clots. Fluorescein can be used to study the blood-brain barrier, and gravimetry to study edema. Others have found that injection of a paraffin/oil mixture can be employed for a control model. Refinement of the fluorescein technique, development of a primate model, and directions for future research are suggested.
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Supported by the Texas Affiliate, Inc., American Heart Association
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Kaufman, H.H., Pruessner, J.L., Bernstein, D.P. et al. A rabbit model of intracerebral hematoma. Acta Neuropathol 65, 318–321 (1985). https://doi.org/10.1007/BF00687015
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DOI: https://doi.org/10.1007/BF00687015