Summary
Selective brain cooling during hyperthermia by emissary venous pathways from the skin of the head to the brain has been reported both in animals and humans. Heat protection of the brain extends tolerance to high deep body temperature in animals, and may be enhanced in humans if the head is cooled. In order to quantify to what extent brain protection could be obtained by face fanning, 9 non-anesthetized human volunteers were placed in ambient conditions as close as possible to those of passive therapeutic hyperthermia. Face-fanning maintained tympanic temperature 0.57° C lower than esophageal temperature, and improved comfort. External head cooling techniques enhancing physiological brain cooling can therefore be useful for the protection of the human brain during heat stress or passive therapeutic hyperthermia.
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Attia M, Khogali M, El-Khatib G, Mustafa MKE, Mahmoud MA, Eldin AN, Gumaa K (1983) Heat-stroke: an upward shift of temperature regulation set point at an elevated body temperature. Int Arch Occup Environ Health 53:9–17
Baker MA (1982) Brain cooling in endotherms in heat and exercise. Ann Rev Physiol 44:85–96
Baker MA, Chapman LW (1977) Rapid brain cooling in exercising dogs. Science 195:781–783
Baker MA, Hayward JN (1967) Carotid rete and brain temperature of cat. Nature 216:139–141
Baker MA, Stocking RA, Meehan JP (1972) Thermal relationship between tympanic membrane and hypothalamus in conscious cat and monkey. J Appl Physiol 32:739–742
Barlogie B, Corry PM, Yip E, Lippman L, Johnston DA, Khalil K, Tenyski TF, Reilly L, Lawson E, Dosik G, Rijor B, Hankenson R, Freireich EJ (1979) Total body hyperthermia with and without chemotherapy for advanced human neoplasm. Cancer Res 39:1481–1489
Brinnel H, Boy J, Cabanac M (1986) Intracranial temperature during passive heat exposure in humans. Brain Res 363:170–173
Brown GA, Williams GM (1982) The effect of head cooling on deep body temperature and thermal comfort in man. Aviat Space Environ Med 53:583–586
Bull JM (1984) A review of systemic hyperthermia. Front Radiat Ther Oncol 18:171–176
Bull JM, Lees DE, Smith R, Schuette WH, Katin M, Glatstein E, DeVita VT (1980) Whole body hyperthermia combined with nitrosurea in malignant melanoma. Proc Am Assoc Cancer Res 21:481
Cabanac M (1983) Face-fanning: A possible way to prevent or cure brain hyperthermia. In: Khogali M, Hales JRS (eds) Heat stroke and temperature regulation. Academic Press, Sydney, pp 213–221
Cabanac M, Caputa M (1979a) Natural selective cooling of the human brain: evidence of its occurrence and magnitude. J Physiol 286:255–264
Cabanac M, Caputa M (1979b) Open loop increase in trunk temperature produced by face cooling in working humans. J Physiol 289:163–174
Cabanac M, Brinnel H (1985) Blood flow in the emissary veins of the human head during hyperthermia. Eur J Appl Physiol 54:172–176
Cabanac M, Brinnel H (1987) The pathology of human temperature regulation: “Thermiatrics”. Experientia 43:19–27
Cabanac M, Brinnel H, Mallet C (1984) Is baldness a thermo-regulatory adaptive process? CR Acad Sci (Paris) 299:499–502
Cabanac M, Germain M, Brinnel H (1987) Tympanic temperatures during hemiface cooling. Eur J Appl Physiol 56:534–539
Caputa M (1980) Selective brain cooling: an important component of thermal physiology. In: Szelenyi Z, Szekely M (eds) Contributions to thermal physiology. Pergamon Press, Oxford, pp 183–192
Caputa M, Cabanac M (1980) Muscular work as thermal behaviour in humans. J Appl Physiol 48:1020–1023
Caputa M, Perrin G, Cabanac M (1978) Ecoulement sanguin réversible dans la veine ophtalmique: mécanisme de refroidissement sélectif du cerveau humain. CR Acad Sci (Paris) 287:1011–1014
Carithers RW, Seagrave RC (1976) Canine hyperthermia with cerebral protection. J Appl Physiol 40:543–548
Crawshaw LJ, Nadel ER, Stolwjik JAJ, Stamford BA (1975) Effect of local cooling on sweating rate and cold sensation. Pflügers Arch 354:19–27
Dickson JA, MacKenzie A, McLeod K (1979) Temperature gradients in pigs during whole-body hyperthermia at 42° C. J Appl Physiol 47:712–717
Dubois M, Sato S, Lees DE, Bull JM, Smith R, White BG, Moore H, MacNamara TE (1980) Electroencephalic changes during whole body hyperthermia in humans. Electroenceph Clin Neurophysiol 50:486–495
Faithfull NS, Reinhold HS, van den Berg AP, van Rhoon GC, van der Zee J, Wike-Hooley JL (1984) Cardiovascular changes during whole-body hyperthermia treatment of advanced malignancy. Eur J Appl Physiol 53:274–281
Fuller CA, Baker MA (1983) Selective regulation of brain and body temperature in the squirrel monkey. Am J Physiol 245:R293-R297
Gerad H, van Echo DA, Whitacre M, Ashman M, Helrich M, Foy J, Ostrow S, Wiernik PH, Aisner J (1984) Doxorubicin, cyclophosphamide, and whole body hyperthermia for treatment of advanced soft tissue sarcoma. Cancer 53:2585–2591
Greenleaf JE, van Beaumont W, Brock PJ, Montgomery LD, Morse JT, Shvartz E, Kravik S (1980) Fluid-electrolyte shifts and thermoregulation: Rest and work in heat with head cooling. Aviat Space Environ Med 51:747–753
Hartman FW (1937) Lesions of the brain following fever therapy, etiology and pathogenesis. J Am Med Ass 109:2116–2121
Hirata K, Nagasaka T, Sugano Y (1978) Effect of alternating respiratory pathway on respiratory capacity, and tympanic and forehead skin temperature during exercise. N J Aerospace Environ Med 15:8–13
Hirata K, Nagasaka T, Nunomora T, Hirai A, Hirashita M (1987) Effects of facial fanning on local exercise performance and thermoregulatory responses during hyperthermia. Eur J Appl Physiol 56:43–48
Jessen C (1984) Hyperthermia as a limit to exercise. In: Garlick DG, Korner PJ (eds) Frontiers in physiological research. Austr Acad Sci, Canberra, pp 348–357
Khogali M, Elkhatib G, Attia M, Mustafa MKY, Gumaa K, Nasr El-Din A, Al Adnani M (1983) Induced heat stroke: A model in sheep. In: Kohgali M, Hales JRS (eds) Heat stroke and temperature regulation. Academic Press, Sydney, pp 253–261
Kissen AT, Hall JF, Klemm FK (1971) Physiological responses to cooling the head and neck versus the trunk and leg areas in severe hyperthermic exposure. Aerosp Med 42:882–888
Lange J, Zanker KS, Siewert JR, Eisler K, Landauer B, Kolb E, Blumel G, Remy W (1983) Extrakorporal induzierte Ganzkörperhyperthermie bei konventionell inkurablen Malignompatienten. Dtsch Med Wochenschr 108:504–509
Larkin JM (1979) A clinical investigation of total-body hyperthermia as cancer therapy. Cancer Res 39:2252–2254
Lind AR (1983) Pathophysiology of heat exhaustion and heat stroke. In: Khogali M, Hales JRS (eds) Heat stroke and temperature regulation. Academic Press, Sydney, pp 179–188
MacDougall JD, Reddan WG, Layton CR, Dempsey A (1974) Effect of metabolic hyperthermia on performance during heavy prolonged exercise. J Appl Physiol 36:538–544
Magilton JH, Swift CS (1968) Description of two physiological heat exchange systems for the control of brain temperature. IEEE Conf. record. 5e and Rocky Mountain Bioengineering Symp, pp 24–27
Malamud N, Haymaker W, Custer RP (1946) Heat stroke: A clinicopathology study of 125 fatal cases. Mil Surg 99:397–449
Maron MB, Wagner JA, Horvath SM (1977) Thermoregulatory responses during competitive marathon running. J Appl Physiol 42:909–914
McCaffrey TV, Geis GS, Chung JM, Wurster RD (1975a) Effect of isolated head heating and cooling in sweating in man. Aviat Space Environ Med 46:1353–1357
McCaffrey TV, McCook RD, Wurster RD (1975b) Effect of head skin temperature on tympanic and oral temperature in man. J Appl Physiol 39:114–118
Mehta AC, Baker RN (1970) Persistent neurological deficits in heat stroke. Neurology 20:336–340
Milligan AJ (1984) Whole body hyperthermia induction techniques. Cancer Res [Suppl] 44:4869–4872
Morgan LD, Vonderhe A (1939) Hypothalamic nuclei in heat stroke, with notes on central representation of temperature regulation. Arch Neurol Psychiatr 42:83–91
Narebski J (1985) Human brain homeothermy during sleep and wakefulness: An experimental and comparative approach. Acta Neurobiol 45:63–75
Noguchi T, Yamamori S, Fujigaki T, Hayano Y, Oda S, Taniguchi K, Honda Y, Honda N (1984) The findings of the brain wave during hyperthermic cancer therapy. Masui 33:33–37
Ostrow S, van Echo D, Whitacre M, Aisner J, Simon R, Wiernik PH (1981) Physiologic response and toxicity in patients undergoing whole-body hyperthermia for the treatment of cancer. Cancer Treat Rep 65:323–325
Pettigrew RT, Galt JM, Ludgate CM, Horn DB, Smith AN (1974) Circulatory and biochemical effects of whole body hyperthermia. Br J Surg 61:727–730
Rawson RO, Hammel HT (1963) Hypothalamic and tympanic membrane temperatures in rhesus monkey. Fed Proc 22:283
Reilly EL, Barlogie B, Seward MA, Corry PM, Rigor B, Yip E (1980) Persistance of EEG activity with prolonged induced hyperthermic fever. Clin Electroenceph 11:22–27
Shiraki K, Konda N, Sagawa S (1986) Esophageal and tympanic temperature responses to core blood temperature changes during hyperthermia. J Appl Physiol 61:98–102
Shvartz E (1970) Effect of a cooling hood on physiological responses to work in a hot environment. J Appl Physiol 29:36–39
Storm FK (1983) Background, principles and practice. In: Storm FK (ed) Hyperthermia in cancer therapy. Hall GK, Boston, pp 1–8
Williams BA, Shitzer A (1974) Modular liquid cooled helmet liner for thermal comfort. Aerosp Med 45:1030–1036
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Brinnel, H., Nagasaka, T. & Cabanac, M. Enhanced brain protection during passive hyperthermia in humans. Europ. J. Appl. Physiol. 56, 540–545 (1987). https://doi.org/10.1007/BF00635367
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DOI: https://doi.org/10.1007/BF00635367