Summary
A constant plasma drug concentration can be achieved and maintained by the intravenous administration of an initial bolus loading dose in conjunction with a constant rate and an exponential intravenous drug infusion. The drug input required to achieve a constant plasma drug concentration is derived without making any assumptions about the nature of drug distribution within the body or elimination from the body.
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Vaughan, D.P., Tucker, G.T. General derivation of the ideal intravenous drug input required to achieve and maintain a constant plasma drug concentration. Theoretical application to lignocaine therapy. Eur J Clin Pharmacol 10, 433–440 (1976). https://doi.org/10.1007/BF00563080
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DOI: https://doi.org/10.1007/BF00563080