Abstract
A stochastic model is proposed to describe time-dependent lethal effects of toxic compounds. It is based on simple mechanistic assumptions and provides a measure for the toxicity of a chemical compound, the so-called killing rate. The killing rate seems a promising alternative for the LC50. The model also provides the no-effect level and the LC50, both as a function of exposure time. The model is applied to real data and to simulated data.
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Bedaux, J.J.M., Kooijman, S.A.L.M. Statistical analysis of bioassays, based on hazard modelling. Environ Ecol Stat 1, 303–314 (1994). https://doi.org/10.1007/BF00469427
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DOI: https://doi.org/10.1007/BF00469427