Summary
We describe our findings in an ultrastructural study of the endolymphatic sac of the mongolian gerbil. In conjunction with its specific renal physiology, enabling this animal to withstand longterm water deprivation, we have used our findings to hypothesize the existence of a local monitoring system within the endolymphatic space. The presence of elastic tissue in the subepithelial space of the endolymphatic sac could explain the mechanism through which this structure equilibrates endolymphatic pressure changes. Finally, we propose that a secretion of water-retaining macromolecules may act through osmotic forces to modulate inner ear fluid.
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Allen GW (1964) Endolymphatic sac and cochlear aqueduct. Arch Otolaryngol 79:322–327
Bagger-Sjöbäck D, Rask-Andersen H (1986) The permeability barrier of the endolymphatic sac. A hypothesis of fluid and electrolyte exchange based on freeze fracturing. Am J Otol 7:134–140
Barbara M, Rask-Andersen H, Bagger-Sjöbäck D (in press) Morphology of the endolymphatic duct and sac in the mongolian gerbil. Acta Otolaryngol (Stockh)
Friberg U, Wackym PA, Bagger-Sjöbäck D, Rask-Andersen H (1986) Effect of labyrinthectomy on the endolymphatic sac. A histological, ultrastructural and computer-aided morphometric investigation in the mouse. Acta Otolaryngol (Stockh) 101:172–182
Guild SR (1927) Observations upon the structure and the normal contents of the ductus and saccus endolymphaticus in the guinea-pig (Cavia cobaya). Am J Anat 39:1–56
Kolmer W (1923) Mikroskopische Anatomie des nervösen Apparates des Ohres. In: Alexander G, Marburg O (Hrsg) Handbuch der Neurologie des Ohres, Vol 1. Urban und Schwarzenberg, Berlin, S 101–174
Lundquist P-G (1965) The endolymphatic duct and sac in the guinea-pig. An electron microscopic and experimental investigation. Acta Otolaryngol (Stockh) [Suppl] 201:1–108
Naftalin L, Harrison MS (1958) Circulation of labyrinthine fluids. J Laryngol 72:118
Rask-Andersen H, Steel K, Erwall K, Friberg U (1987) The endolymphatic sac in the mouse mutant with cochleo-saccular degeneration. Electrophysiological and ultrastructural correlations. Hear Res 26:177–190
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Supported by grants from the Swedish Medical Research Council N. 00720-03908 and from the Centro Nazionale delle Ricerche, Italy
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Barbara, M., Rask-Andersen, H. & Bagger-Sjöbäck, D. Ultrastructure of the endolymphatic sac in the mongolian gerbil. Arch Otorhinolaryngol 244, 284–287 (1987). https://doi.org/10.1007/BF00468637
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DOI: https://doi.org/10.1007/BF00468637