Abstract
This paper gives the clinical, immunological and virological data on a patient with agammaglobulinemia who developed paralytic poliomyelitis. The patient was a 3 year-old boy who had a typical B-cell defect without a T-cell defect. He had profound hypogammaglobulinemia and defective plasma cells and had repeated pyogenic infections which were controlled by gammaglobulin replacement therapy. At 3 years of age, he was admitted to our hospital with suspected meningitis. He had fever, tremor and neck stiffness for 3 days and subsequently developed paralysis in his left arm and right leg. There was lymphocytosis in the cerebrospinal fluid. A non vaccine-like strain of poliovirus type 2 was isolated from the stool.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Barnett, E. V., Nasou, J. P., Utz, J. P., Baron, S.: Antibodies to enteroviruses in hypogammaglobulinemic patients. New Engl. J. Med. 262, 563–565 (1960)
Baron, S.: Mechanism of recovery from viral infection. Advance. Viro. Res. 10, 39–60 (1963)
Baron, S., Nasou, J. P., Friedman, R. M., Owen, G. M., Levy, H. B., Barnett, E. V.: Antibody production by hypogammaglobulinemic patients. J. Immunol. 88, 443–449 (1962)
Chang, T. W., Weinstein, L., Macmahon, E.: Paralytic poliomyelitis in a child with hypogammaglobulinemia: Probable implication of type 1 vaccin strain. Pediatrics 37, 630–636 (1966)
Davis, L. E., Bodian, D., Price, D., Butler, I. J., Vicker, J. M.: Chronic progressive poliomyelitis secondary to vaccination of an immunodeficient child. New Engl. J. Med. 297, 241–245 (1977)
Hill, L. E., et al.: Hypogammaglobulinemia in The United Kingdom. Lancet 1969 I, 163–168
Feigin, R. D., Guggenheim, M. A., Johnson, S. D.: Vaccine-related paralytic poliomyelitis in an immunodeficient child. J. Fed. 79, 642–647 (1971)
Good, R. A., Page, A. R.: Fatal complications of virus hepatitis in two patients with agammaglobulinemia. Am. J. Med. 29, 804–810 (1960)
Fulginiti, V. A., Kempe, C. H., Hathaway, W. E., et al.: Progressive vaccinia in immunological deficient individuals. In: Immunologic deficiency disease in man. No. 1. Birth Defects Original Article Series, D. Bergsma (ed.), Vol. 4, pp. 129–145. New York: The National Foundation 1968
Jacox, R. F., Mongan, E. S., Hanshaw, J. B., Leddy, J. P.: Hypogammaglobulinemia with thymoma and proble pulmonary infection with cytomegalovirus. New Engl. J. Med. 271, 1091–1096 (1964)
Kramer, R. I., Cirone, V. C., Moore, H.: Intestitial pneumonia due to pneumocystis carinii, cytomegalic inclusion disease and hypogammaglobulinemia occurring simultaneously in an infant. Pediatrics 29, 816–827 (1962)
Takatsu, T., Tagaya, I., Hirayama, M.: Poliomyelitis in Japan during the period 1962–1968 after the introduction of mass vaccination with Sabin vaccine. Bull. Wld. Hlth. Org. 49, 129–137 (1973)
Tagaya, I., Nakao, C., Hara, M., Yamadera, S.: Characterization of poliovirus isolated in Japan after the mass vaccination with live oral poliomyelitis vaccine (Sabin). Bull. Wld. Hlth. Org. 48, 547–554 (1962)
Tagaya, I., Hirayama, M.: Poliomyelitis in Japan during the period 1962–1973. Jap. Med. J. 2659, 31–34 (1975)
Verhaart, W. J. C.: Polio-encephalopathy or masked encephalitis in familial hypogammaglobulinemia. J. Neuropathol. Exp. Neurol. 20, 380–385 (1961)
Wilfert, C. M., Buckley, R. H., Mohanakumar, T., Griffith, J. F., Katz, S. L., Whisnant, J. K., Eggleston, P. A., Moore, M., Treadwell, E., Oxman, M. N., Rosen, F. S.: Persistent and fatal central-nervous-system echovirus infections in patients with agammaglobulinemia. New Engl. J. Med. 296, 1485–1489 (1977)
Wright, P. F., Hatch, M. H., Kasselberg, A. G., Lowry, S. P., Wadlington, W. B., Karzon, D. T.: Vaccine-associated poliomyelitis in a child with sex-linked agammaglobulinemica. J. Ped. 91, 408–412 (1977)
Wyatt, H. V.: Poliomyelitis in hypogammaglobulinemics. J. Infect. Dis. 128, 802–806 (1973)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Abo, W., Chiba, S., Yamanaka, T. et al. Paralytic poliomyelitis in a child with agammaglobulinemia. Eur J Pediatr 132, 11–16 (1979). https://doi.org/10.1007/BF00443199
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00443199