Abstract
Background
Oral polio vaccine can rarely lead to Vaccine-associated paralytic poliomyelitis (VAPP).
Case characteristics
A 2-year-old child with asymmetric paralysis of lower limbs following first booster of oral polio vaccine; type 2 Vaccine-derived poliovirus (VDPV) isolated. Subsequently, the child was diagnosed to have common variable immunodeficiency.
Outcome
Paralysis gradually improved on follow-up; monthly intravenous immunoglobulin therapy started for primary immunodeficiency.
Message
We need to evaluate children with VAPP for underlying immunodeficiency.
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Gomber, S., Arora, V. & Dewan, P. Vaccine associated paralytic poliomyelitis unmasking common variable immunodeficiency. Indian Pediatr 54, 241–242 (2017). https://doi.org/10.1007/s13312-017-1038-x
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DOI: https://doi.org/10.1007/s13312-017-1038-x