Abstract
Signal detection analysis was used to examine the effects of d-amphetamine and of morphine on auditory discrimination in female rats. The probability of response repetition in the discrete trial two-choice discrimination procedure was used as an additional behavioral measure. d-Amphetamine (0.4–3.2 mg/kg) and morphine (1.88–15.0 mg/kg) decreased the sensitivity measures (A′ and SI) but did not consistently affect the response bias measures (B″ and RI). The probability of response repetition was increased by d-amphetamine and was not affected by morphine. It is concluded that the response bias measure B″, derived from signal detection theory, and the empirical response bias measure RI, do not discriminate between the different ways in which d-amphetamine and morphine affect discriminative responding, under the conditions of this study.
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References
Altman JL, Appel JB, Mc Gowan WT (1979) Drugs and the discrimination of duration. Psychopharmacology 60:183–188
Appel JB, Dykstra LA (1977) Drugs, discrimination and signal detection theory. In: Thompson T, Dews PB (eds) Advances in behavioral pharmacology, vol 1. Academic, New York, pp 139–166
Blough DS (1969) Generalization gradient shape and summation in steady-state tests. J Exp Anal Behav 12:91–104
Dykstra LA, Appel JB (1974) Effects of LSD on auditory perception: A signal detection analysis. Psychopharmacologia 34:289–307
Frey PW, Colliver JA (1973) Sensitivity and reposivity measures for discrimination learning. Learning and Motivation 4:327–342
Grier JB (1971) Nonparametric indexes for sensitivity and bias: Computing formulas. Psychol Bull 75:424–429
Grilly DM (1981) A signal detection analysis of morphine effects on the response bias of rats in a two-shock discrimination task. Life Sci 28:1883–1888
Hernandez LL, Appel JB (1979) An analysis of some perceptual effects of morphine, chlorpromazine and LSD. Psychopharmacology 60: 125–130
Hernandez LL, Appel JB (1980) Effects of pentazocine and other opiates on shock detection in the rat: involvement of opiate and dopamine receptors. Psychopharmacology 67:155–163
Nielsen EB (1981) Effects of d-amphetamine and LSD on simultaneous discrimination. In: Bradshaw CM, Szabadi E, Lowe CF (eds) Quantification of steady-state operant behavior. Elsevier/North-Holland, Amsterdam, pp 461–464
Rapp DL, Robbins TW (1976) The effects of d-amphetamine on temporal discrimination in the rat. Psychopharmacology 51:91–100
Robbins TW, Watson BA (1981) Effects of d-amphetamine on response repetition and win-stay behavior in rat. In: Bradshaw CM, Szabadi E, Lowe CF (eds) Quantification of steady-state operant behavior. Elsevier/North-Holland, Amsterdam, pp 441–444
Stubbs DA, Thomas JR (1974) Discrimination of stimulus duration and d-amphetamine in pigeons: A psychophysical analysis. Psychopharmacologia 36:313–322
Thompson DM (1978) Stimulus control and drug effects. In: Blackman DE, Sanger DJ (eds) Contemporary research in behavioral pharmacology. Plenum, New York, pp 159–207
Vitaliano PP, Prinz P, Vitiello MV, Olshan A, Roehrs TA (1981) On the use of repeated measures designs in pharmacology. Psychopharmacology 72:247–249
Winer BJ (1971) Statistical principles in experimental design, 2nd edn. McGraw Hill, New York
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Koek, W., Slangen, J.L. Effects of d-amphetamine and morphine on discrimination: signal detection analysis and assessment of response repetition in the performance deficits. Psychopharmacology 80, 125–128 (1983). https://doi.org/10.1007/BF00427954
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DOI: https://doi.org/10.1007/BF00427954