Abstract
In three cebus monkeys the chronic daily administration of haloperidol (0.5 mg/kg/day orally) created sedation and parkinsonism during the first 5–7 weeks. Later the animals developed signs reminiscent of acute dystonia, as seen in the clinic during treatment with neuroleptics. These signs were dose-dependent and in extreme cases included widespread tonic and clonic seizures. After 3 and 12 months, respectively, two of the cebus monkeys developed buccolingual signs (grimacing and tongue protrusion), similar to tardive dyskinesia in the clinic.
The tardive dyskinesia symptoms were reduced in a dose-dependent manner after each haloperidol administration, being most pronounced in the morning before haloperidol was given. Biperiden reduced acute dystonia but reinstated signs of tardive dyskinesia, which had been abolished by haloperidol. It is suggested that cebus monkeys may provide a useful animal model for the study of neurologic long-term complications from neuroleptic drugs.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Ayd, F. J.: Persistent dyskinesia: a neurologic complication of major tranquilizers. Med. Sci. 18, 32–40 (1967)
Bédard, P., LaRochelle, L., De Léan, J., Lafleur, J.: Dyskinesias induced by long term administration of haloperidol in the monkey. Physiologist 15, 83 (1972)
Crane, G. E.: Persistent dyskinesia. Brit. J. Psychiat. 122, 395–405 (1973)
Deneau, G. A., Crane, G. E.: Dyskinesia in rhesus monkeys tested with high doses of chlorpromazine. In: Psychotropic drugs and dysfunctions of the basal ganglia, G. E. Crane and J. R. Gardner, eds., pp. 12–24. U.S. Publ. Health Service, Publ. No. 1938, (1969)
Marsden, C. D., Tarsy, D., Baldessarini, R. J.: Spontaneous and drug-induced movement disorders in psychotic patients. In: Psychiatric aspects of neurological disease, D. F. Benson and D. Blumer, eds., pp. 219–266. New York: Grune & Stratton 1975
Messiha, F. S.: The relationship of dopamine excretion to chlorpromazine-induced dyskinesia in monkeys. Arch. int. Pharmacodyn. 209, 5–9 (1974)
Messiha, F. S.: A study of biogenic amine metabolites in the cerebrospinal fluid and urine of monkeys with chlorpromazine-induced dyskinesia. J. neurol. Sci. 21, 39–46 (1974)
Paulson, G. W.: Dyskinesias in monkeys. Advances in neurology, A. Barbeau, T. N. Chase, and G. W. Paulson, eds., vol. 1, pp. 647–650. New York: Raven Press 1973
Sassin, J. F.: Drug-induced dyskinesia in monkeys. Advances in neurology, B. S. Meldrum and C. D. Marsden, eds., vol. 10, pp. 47–54. New York: Raven Press 1975
Weiss, B.: Long-term behavioural consequences of exposure to drugs and pollutants. In: Alcohol, drugs and brain damage, J. G. Rankin, ed., pp. 71–79. Toronto: Addiction Research Foundation of Ontario 1975a
Weiss, B.: Episodic hyperkinesia in monkeys following chronic haloperidol. Neuroscience abstracts, vol. 1, p. 238. 5th Annual Meeting of the Society for Neuroscience, New York 1975b
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gunne, LM., Bárány, S. Haloperidol-induced tardive dyskinesia in monkeys. Psychopharmacology 50, 237–240 (1976). https://doi.org/10.1007/BF00426838
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00426838