Abstract
The effect of amantadine and (+)-amphetamine on motility was investigated by subcutaneous administration to rats. Amantadine 50 and 100 mg/kg induced a moderate increase of motility. (+)-amphetamine 1, 2.5 and 5 mg/kg showed a more potent locomotor stimulant effect. A stereotyped licking was found during the hypermotility induced by (+)-amphetamine 5 mg/kg.
Pretreatment with the catecholamine synthesis inhibitor α-methyl-p-tyrosine inhibited the effect of (+)-amphetamine but not that of amantadine. Reserpine potentiated the effects of both amantadine and (+)-amphetamine. Tetrabenazine antagonized the hyperactivity produced by (+)-amphetamine but potentiated amantadine induced hyperactivity. The locomotor stimulant effect of amantadine seems to differ in certain respects from that of amphetamine.
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Lassen, J.B. The effect of amantadine and (+)-amphetamine on motility in rats after inhibition of monoamine synthesis and storage. Psychopharmacologia 29, 55–64 (1973). https://doi.org/10.1007/BF00421211
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DOI: https://doi.org/10.1007/BF00421211