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Diabetes Epidemiology Research International Group (1990) Secular trends in incidence of childhood IDDM in 10 countries. Diabetes 39: 858–864
Murphy AE, Chase GA (1975) Principles of genetic counselling. Yearbook Medical Publishers, Chicago, pp 343–372
Anderson S, Bankler AT, Barek BG et al. (1981) Sequence and organization of the human mitochondrial genome. Nature 290: 457–465
Cann RL, Stoneking M, Wilson AC (1987) Mitochondrial DNA and human evolution. Nature 325: 31–36
Hasegawa M, Horai S (1991) Time of the deepest root for polymorphism in human mitochondrial DNA. J Mol Evol 32: 37–42
Di Rienzo A, Wilson AC (1991) Branching pattern in the evolutionary tree for human mitochondrial DNA. Proc Natl Acad Sci USA 78: 5768–5772
Shay JW, Werbin H (1990) Cytoplasmic regulation of cellular differentiation: a role for mitochondria in carcinogenesis. In: Fisher PB (ed) Mechanisms of differentiation, vol I: model cell culture systems for studying differentiation. CRC Press, Inc., Boca Raton, pp 135–159
Kunkel TA, Loeb LA (1981) Fidelity of mammalian DNA polymerases. Science 213: 765–768
Richter C (1988) Do mitochondrial DNA fragments promote cancer and aging? FEBS Lett 241: 1–5
Richter C, Park JW, Ames BN (1988) Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 85: 6465–6467
Holt IJ, Harding AE, Morgan-Hughes JA (1988) Deletions of muscles mitochondrial DNA in patients with mitochondrial myopathies. Nature 331: 717–719
Wallace DC, Lott MT, Torroni A, Shoffner JM (1991) Report of the committee on human mitochondrial DNA. Cytogenet Cell Genet 58: 1103–1123
Lin FH, Lin R, Wiesniewski HM et al. (1992) Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains. Biochem Biophys Res Comm 182: 238–246
Moncada S, Palmer RMJ, Higgs EA (1991) Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43: 109–142
Corbett JA, Lancaster JR, Sweetland MA, McDaniel ML (1991) Interleukin 1 β-induced formation of EPR-detectable ironnitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1β-induced inhibition of insulin secretion. J Biol Chem 266: 21351–21354
Sandler S, Bendtzen K, Borg LAH, Eizirik DL, Strandell E, Welsh N (1989) Studies on the mechanism causing inhibition of insulin secretion in rat pancreatic islets exposed to human interleukin-1β indicate a perturbation in the mitochondrial function. Endocrinology 124: 1492–1501
Welsh N, Sandler S (1992) Interleukin-1β induces nitric oxide production and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets. Biochem Biophys Res Comm 182: 333–340
Hogg N, Durley-Usmar VM, Wilson MT, Moncada S (1992) Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem J 281: 419–424
Uchigata Y, Yamamoto H, Kawamura H, Okamoto H (1982) Protection by superoxide dismutase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks. J Biol Chem 257: 6084–6088
Wilson GL, Hartig PC, Patton NJ, Le Doux S (1988) Mechanisms of nitrosourea-induced β-cell damage. Diabetes 37: 213–216
Halliwell B, Aruoma OI (1991) DMA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems. FEBS Lett 281: 9–19
Malaisse WJ, Malaisse-Lagae F, Sener A, Pipeleers DG (1982) Determinants of selective toxicity of alloxan to the pancreatic β-cell. Proc Natl Acad Sci 79: 927–930
Le Doux SP, Hall CR, Forbes PM, Patton NJ, Wilson GL (1988) Mechanisms of nicotinamide and thymidine protection from alloxan and streptozotocin toxicity. Diabetes 37: 1015–1019
Eliott RB, Chase HP (1991) Prevention or delay of type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide. Diabetologia 34: 362–365
Okamoto H (1990) The molecular basis of experimental diabetes In: Okamoto H (ed) The molecular biology of the islets of Langerhans. Cambridge University Press, Cambridge, pp 209–231
Wilson GL, Leiter EH (1990) Streptozotocin interactions with pancreatic β-cell in the induction of insulin-dependent diabetes. Curr Topics Microbiol Immunol 156: 27–54
Eizirik DL, Sandler S, Ahnström G, Welsh M (1991) Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces longlasting functional impairment of B-cells. Biochem Pharmacol 42: 2275–2282
Asayama K, Kooy NW, Burr IM (1986) Effect of vitamin E deficiency and selenium deficiency on insulin secretory reserve and free radical scavenging systems in islets: decrease of islet mangano superoxide dismutase. J Lab Clin Med 107: 459–464
Hruskewycz AM (1988) Evidence for mitochondrial DNA damage by lipid peroxidation. Biochem Biophys Res Comm 153: 191–197
Svensson C, Welsh N, Krawetz S, Welsh M (1991) Exhibition of specific alterations in activities and mRNA levels of rat islet glycolytic and mitochondrial enzymes in three different in vitro model systems for attenuated insulin release. Diabetes 40: 771–776
Welsh N, Pääbo S, Welsh M (1991) Decreased mitochondrial gene expression in isolated islets of rats injected neonatally with streptozotocin. Diabetologia 34: 626–631
Pettepher CC, Le Doux SP, Bohr VA, Wilson GL (1991) Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin. J Biol Chem 266: 3113–3117
Wunderlich V, Schüt M, Böttger M, Graffi A (1970) Preferential alkylation of mitochondrial deoxyribonucleic acid by N-methyl-N-nitrosourea. Biochem J 118: 99–109
Satoh MS, Huh N, Rajewsky MF, Kuroki T (1988) Enzymatic removal of O6-ethylguanine from mitochondrial DNA in rat tissues exposed to N-ethyl-N-nitrosourea in vivo. J Biol Chem 263: 6854–6856
Eizirik DL, Sandler S, Welsh N, Hellerström C (1988) Preferential reduction of insulin production in mouse pancreatic islets maintained in culture after streptozotocin exposure. Endocrinology 122: 1242–1249
Mita S, Rizzuto R, Moraes CT et al. (1990) Recombination via flanking direct repeats is a major cause of large scale deletions of human mitochondrial DNA. Nucl Acid Res 18: 561–567
Obermaier-Kusser B, Müller-Höcker J, Nelson I et al. (1990) Different copy number of apparently identically deleted mitochondrial DNA in tissues from a patient with Kearns-Sayre syndrome detected by PCR. Biochem Biophys Res Comm 169: 1007–1015
Hayashi JI, Ohta S, Kikuchi A, Takemitsu M, Goto YI, Nonaka I (1991) Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction. Proc Natl Acad Sci USA 88: 10614–10618
Loveland B, Wang CR, Yonegawa H, Hermel E, Fischer-Lindahl K (1990) Maternally transmitted histocompatibility antigen of mice: a hydrophobic peptide of a mitochondrially encoded protein: Cell 60: 971–980
Klinkhammer C, Popowa P, Gleichmann H (1988) Specific immunity to streptozotocin. Cellular requirements for induction of lymphoproliferation. Diabetes 37: 74–80
Fischer-Lindahl K, Hermel E, Loveland BE, Wang CR (1991) Maternally transmitted antigen of mice: a model transplantation antigen. Annu Rev Immunol 9: 351–372
Quade A, Zierz S, Klingmüller D (1988) Endokrinologische Störungen bei Ophthalmoplegie plus/Kearns-Sayre Syndrom. Klin Wochenschr 66 [Suppl XIII]: 272–273
Lakin M, Locke S (1961) Progressive ocular myopathy with ovarian insufficiency and diabetes mellitus. Report of a case. Diabetes 10: 228–231
Tanabe Y, Migamoto S, Kinoshita Y et al. (1988) Diabetes mellitus in Kearns-Sayre syndrome. Eur Neur 28: 34–38
Enter C, Müller-Höcker J, Zierz S et al. (1991) A specific point mutation in the mitochondrial genome of caucasians with MELAS: Hum Genet 88: 233–236
Rotig A, Bessis IL, Romero N et al. (1992) Maternally inherited duplication of the mitochondrial genome in a syndrome of proximal tubulopathy, diabetes mellitus and cerebellar ataxia. Amer J Hum Genetics 50: 364–370
Ballinger SW, Shoffner JM, Hedaya EV et al. (1992) Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion. Nature Genetics 1: 11–15
van den Ouweland JMW, Lemkes H, Maassen JA (1991) A rare mitochondrial BstNI polymorphism in a family with type 2 diabetes. Nucl Acid Res 19: 1962
Avise JC (1991) Ten unorthodox perspectives on evolution prompted by comparative population genetic findings on mitochondrial DNA. Annu Rev Genet 25: 45–69
Hayashi JI, Tanaka M, Sato W et al. (1990) Effects of ethidium bromide treatment of mouse cells on the expression and assembly of nuclear-encoded subunits of complexes involved in the oxidative phosphorylation. Biochem Biophys Res Comm 167: 216–221
Like AA, Rossini AA (1976) Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 193: 415–417
Karam JH, Lewitt PA, Young CW et al. (1980) Insulinopenic diabetes after rodenticide (Vacor) ingestion. A unique model for acquired diabetes in man. Diabetes 29: 971–978
Helgason T, Ewen SWB, Ross IS, Stowers JM (1982) Diabetes in mice produced by smoked/cured mutton. Lancet II: 1017–1024
Wallace DC (1987) Maternal genes: mitochondrial diseases. Birth Defects 23: 137–190
Warram JH, Krolewski AS, Gottlieb MS, Kahn CR (1984) Difference in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. N Engl J Med 311: 149–152
Todd JA (1991) A prospective role of the environment in the development of type 1 diabetes. Diabetic Med 8: 906–910
Wallace DC (1992) Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 256: 628–632
Dionne FT, Turcotte L, Thibault C, Bouley MR, Skinner JS, Bouchard C (1991) Mitochondrial DNA sequence polymorphism VO2max, and response to endurance training. Med Sci Sports Exerc 23: 177–185
Ozawa T, Tanaka M, Sugiyama S et al. (1991) Patients with idiopathic cardiomyopathy belong to the same mitochondrial DNA gene family of Parkinsons's disease and mitochondrial encephalomyopathy. Biochem Biophys Res Comm 177: 518–525
Brown MD, Voljavec AS, Lott MT, Torroni A, Yang CC, Wallace DC (1992) Mitochondrial DNA complex I and III mutations associated with Leber's hereditary opticus neuropathy. Genetics 130: 163–173
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Gerbitz, K.D. Does the mitochondrial DNA play a role in the pathogenesis of diabetes?. Diabetologia 35, 1181–1186 (1992). https://doi.org/10.1007/BF00401375
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DOI: https://doi.org/10.1007/BF00401375