Abstract
The problem of looking for high efficient modern control strategies in fermentation technology is very urgent, nowdays. Particular attention should be paid to the processes in fed-batch mode. Both, optimal feedforward and feedback control approaches are suggested. A contribution is considered to have been made in the feedback control where continuous and discrete versions are treated as well. The control laws are carried out by a variation calculus problem and a polynomial pole placement synthesis solution, respectively. All the algorithms result in an optimal substrate feed rate profile. On the basis of recursive least squares identification of the model coefficients an adaptive discrete-time control strategy is proposed. Some satisfying simulation results are dealt with.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
San, K. Y.; Stephanopoulos, G.: Biotechnol. Bioeng. 26 (1984) 161
Lim, H. C.; Tayleb, Y. J.; Modak, J. M.; Bonte, P.: Biotechnol. Bioeng. 28 (1986) 1408
Modak, J. M.; Lim, H. C.: Biotechnol. Bioeng. 30 (1987) 528
Reuss, M.: Computer control of bioreactors. Present limits and challenges for the future. In: Preprints of 3rd Conf. on Chemical process control, Asimolar, California (USA), 1986, p. 641
Yamané, T.; Shimizu, S.: Advances in Biochemical Eng./Biotech. 30, Springer-Verlag Berlin, Heidelberg, 1984, p. 147
Kučera, V.: Discrete linear control. Academia, Prague, 1979, p. 206
Strejc, V.: State-space theory of linear discrete control (in Czech.). Academia, Prague, 1978, p. 374
Pontryagin, L. S.; Boltyanskii, V. G.; Gamkrelidze, R. V.; Mishchenko, E. F.: The mathematical theory of optimal processes. Interscience, New York, 1962
Mészáros, A.: A contribution to the control of biochemical reactors (in Slovak.). In: Preprints of 14 Symp. of the Slovak Society for Cybernetics, Bratislava, 1988, p. 162
El'sgolc, L. E.: Variation calculus (in Russian), Gostechizdav, Moscow, 1958
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mészáros, A., Bales, V. A contribution to optimal control of fed-batch biochemical processes. Bioprocess Engineering 7, 363–367 (1992). https://doi.org/10.1007/BF00369492
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00369492