Summary
We report the localization of amyloid β-protein and sulfated glycosaminoglycans in senile plaques and vascular amyloid deposits in brain tissues from patients with Down's syndrome and Alzheimer's discase, and in neurofibrillary tangles of these diseases and those of Guamanian parkinsonism-dementia and amyotrophic lateral sclerosis. We also report the immunolocalization of scrapie amyloid in amyloid plaques containing glycosaminoglycans in kuru, Creutzfeldt-Jakob disease, and Gerstmann-Sträussler's syndrome. Thus, amyloidogenic proteins and sulfated glycosaminoglycans may be copolymerized in amyloid deposits in the nontransmissible and transmissible cerebral amyloidoses.
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Brown P, Coker-Vann M, Pomeroy K, Franko M, Asher DM, Gibbs CJ Jr, Gajdusek DC (1986) Diagnosis of Creutzfeldt-Jakob disease by Western blot identification of marker protein in humen brain tissue. N Engl J Med 314:547–551
Dorling J (1969) Critical electrolyte concentration method in histochemistry. J Med Lab Technol 26:124–130
Goldgaber D, Lerman MI, McBride OW, Saffiotti U, Gajdusek DC (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235:877–880
Guiroy DC, Gajdusek DC (1989) Fibril-derived amyloid enhancing factor as nucleating agents in Alzheimer's disease and transmissible virus dementia. Disc Neurosci 5:69–73
Guiroy DC, Gajdusek DC (1990) Modification of host precursor proteins to amyloid fibrils in Alzheimer's disease. In: Harrison MG (ed) Genetic effects of aging, II. Telford Press, Caldwell, pp 543–556
Guiroy DC, Miyazaki M, Multhaup G, Fischer P, Garruto RM, Beyreuther K, Masters CL, Simms G, Gibbs CJ Jr, Gajdusek DC (1987) Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence. Proc Natl Acad Sci USA 84:2073–2077
Guiroy DC, Williams ES, Yanagihara R, Gajdusek DC (1991) Topographic distribution of scrapie amyloid-immunoreactive plaques in chronic wasting disease in captive mule deer (Odocoileus hemionus hemionus). Acta Neuropathol 81:475–478
Guiroy DC, Williams ES, Yanagihara R, Gajdusek DC (1991) Immunolocalization of scrapie amyloid (PrP 27–30) in chronic wasting disease of Rocky Mountain elk and hybrids of captive mule deer and white-tailed deer. Neurosci Lett (in press)
Kang J, Lemaire H, Unterbeck A, Salbaum J, Masters C, Grzeschik K, Multhaup G, Beyreuther K, Müller-Hill B (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell surface receptor. Nature 325:733–736
Kitamoto T, Ogomori K, Tateishi J, Prusiner SB (1987) Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids. Lab Invest 57:230–236
Mowry RW, Scott JE (1967) Observations on the basophilia of amyloids. Histochemie 10:8–32
Oesch B, Westaway D, Wälchili M, McKinley MP, Kent SB, Aebersold R, Barry RA, Tempst P, Teplow DB, Hood LE, Prusiner SB, Weissmann C (1985) A cellular gene encodes scrapie PrP 27–30 protein. Cell 40:735–746
Palmoski MJ, Brandt KD (1975) Stimulation of glycosaminoglycans biosynthesis by amyloid fibril. Biochem J 148:145–147
Pras M, Nevo Z, Schubert M, Rotman J, Matalon R (1971) The significance of mucopolysaccharides in amyloid. J Histochem Cytochem 19:443–448
Scott JE, Dorling J (1965) Differential staining of acid glycosaminoglycans (mucopolysaccharides) by Alcian blue in salt solutions. Histochemie 5:221–223
Snow AD, Kisilevsky R (1985) Temporal relationship between glycosaminoglycan accumulation and amyloid deposition during experimental amyloidosis: a histochemical study. Lab Invest 53:37–44
Snow AD, Willmer J, Kisilevsky R (1987) A close ultrastructural relationship between sulfated proteoglycans and AA amyloid fibrils. Lab Invest 57:687–698
Snow AD, Mar H, Nochlin D, Kimata K, Kato M, Suzuki S, Hassell J, Wight TN (1988) The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease. Am J Pathol 133:456–463
Snow AD, Nochlin D, Lara S, Wight TN (1988) Cationic dyes reveal proteoglycans to be ultrastructurally integrated within the amyloidotic lesions of Alzheimer's disease. Neurology 38:266
Snow AD, Wight TN, Nochlin D, Koike Y, Kimata K, De Armond SJ, Prusiner SB (1990) Immunolocalization of heparan sulfate proteoglycan to the prion protein amyloid plaques of Gerstmann-Sträussler's syndrome, Creutzfeldt-Jakob disease and scrapie. Lab Invest 63:601–611
Sternberger LA (1986) Immunocytochemistry. Wiley, New York, pp 90–200
Tanzi RE, Gusella JF, Watkins PC, Bruns GAP, St. George-Hyslop P, van Keuren ML, Patterson D, Pagan S, Kurnit D, Neve RL (1987) Amyloid β-protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235:880–884
Wong CW, Quaranta V, Glenner GG (1985) Neuritic plaques and cerebrovascular amyloid in Alzheimer's disease are antigenically related. Proc Natl Acad Sci USA 82:8729–8732
Wood GC (1960) The formation of fibrils from collagen solutions. III. Effect of chondroitin sulphate and some other naturally occurring polyanions on the rate of formation. Biochem J 75:605–612
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Guiroy, D.C., Yanagihara, R. & Gajdusek, D.C. Localization of amyloidogenic proteins and sulfated glycosaminoglycans in nontransmissible and transmissible cerebral amyloidoses. Acta Neuropathol 82, 87–92 (1991). https://doi.org/10.1007/BF00293949
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DOI: https://doi.org/10.1007/BF00293949