Abstract
Radiation osteoporosis was assessed with single energy quantitative computed tomography (QCT) on 23 patients with cervical cancer. Eleven cases formed the radiation group, who received irradiation to the lumbar column. The other 12 cases formed the control group and were not irradiated. The absorbed dose to the lumbar column was 45 Gy over 5 weeks in nine cases and 22.5 Gy over 5 weeks in two cases. Bone mineral content (BMC) at the 3rd lumbar vertebra was scanned with QCT. BMC reduction was substantial in the radiation group and not evident in the control group. The mean reduction of the former was 52 mg/cm3 at the end of irradiation. The differences in changes of BMC between the two groups was statistically significant (p = 0.01). The two cases who received 22.5 Gy revealed similar BMC reduction to those who received 45 Gy. QCT performed at the end of irradiation demonstrated that more than 22.5 Gy over 5 weeks induced substantial osteoporotic changes.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Rubin P, Casarett GW (1972) Clinical Radiation Pathology. Saunders, Philadelphia
Nishimura T, Shimizu T, Sugiyama A, Ichinole K, Teshima T, Takahashi M, Takai M, Kaneko M (1990) Insufficiency fracture of the pelvis after the radiotherapy for carcinoma of the uterine cervix. Nippon Acta Radiol 50: 1243–1252
Gluer CC, Steiger P, Selvidge R, Genant HK (1990) Comparative assessment of dual-photon absorptiometry and dual-energy radiography. Radiology 174: 223–228
Cann CE, Genant HK (1980) Precise measurement of vertebral mineral content using computed tomography. J Comput Assist Tomogr 4: 493–500
Moss WT (1989) Radiation Oncology. Mosby, St. Louis
Dahl DC (1936) La theorie de L'osteoclasie et le comportement des osteoclastes vis a vis du bleu trypan et vis a vis de l'irradiation aux rayons X. Acta Pathol Microbiol Scand Suppl 26: 234–239
Genant HK, Cann CE, Mucelli RSP, Kanter AS (1982) Vertebral mineral determination by quantitative CT. J Comput Assist Tomogr 7: 554
Howland WJ, Loeffler RK, Stachman DE, Johnson RG (1975) Postirradiation atrophic changes of bone and related complications. Radiology 117: 677–685
Sengupta S, Prathap K (1973) Radiation necrosis of the humerus: a report of three cases. Acta Radiol [Ther] 12: 313–320
Cann CE, Genant HK, Kolb FO (1984) Quantitative computed tomography for prediction of vertebral fracture risk. Metab Bone Dis Relat Res 5: 1–7
Genant HK, Cann CE, Boyd DP (1983) Quantitative computed tomography for mineral determination. In: Proceedings of Henry Ford Hospital Symposium on Clinical Disorders of Bone and Mineral Metabolism. Excepta Medica, New York, pp 40–47
Author information
Authors and Affiliations
Additional information
This paper was presented in part in ECT'91
Correspondence to: K. Nishiyama
Rights and permissions
About this article
Cite this article
Nishiyama, K., Inaba, F., Higashihara, T. et al. Radiation osteoporosis — an assessment using single energy quantitative computed tomography. Eur. Radiol. 2, 322–325 (1992). https://doi.org/10.1007/BF00175435
Issue Date:
DOI: https://doi.org/10.1007/BF00175435