Abstract
It has been considered for some time that the molecular basis of heart failure may be broadly categorized into defects in energy production or defects in energy utilization (Olson, 1959). Even though defects in energy production have been demonstrated in some instances, energy stores in general have been reported to be normal in many models of heart failure (Wollenberger, 1949). The excitation-contraction coupling component of energy utilization has long been suspected to have a role in the failing heart mechanism (Nayler, 1963). Calcium has been considered to play a central role in this excitation-contraction process, and recently Dhalla (1976) has suggested that both calcium deficiency and calcium overload within the cardiac cells may be involved in the mechanism of heart failure.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Anand, M. B.; Chauhan, M. S.; and Dhalla, N. S. Ca+2/Mg+2 ATPase activities of heart sarcolemma, microsomes, and mitochondria. J. Biochem., 82, 1731–1739 (1977).
Appelt, A. W.; Welty, J. D.; and Peterson, M. B. Changes in sarcolemmal and sarcoplasmic reticulum ATPase activities with age in the cardiomyopathy Syrian hamster. J. Mol. Cell. Cardiol, 8, 901–907 (1976).
Bajusz, E. Dystrophic calcification of myocardium as conditioning factor in genesis of congestive heart failure: An experimental study. Am. Heart J., 78, 202–210 (1969).
Bajusz, E.; and Lossnitzer, K. A new disease model of chronic congestive heart failure: Studies on its pathogenesis. Trans. N.Y. Acad. Sci, 30 (Sec. II), 939–948 (1968).
Bajusz, E.; Baker, J. R.; Nixon, C. W.; and Homburger, F. Spontaneous hereditary myocardial degeneration and congestive heart failure in the Syrian hamster. Ann. N.Y. Acad. Sci, 156, 105–129 (1969).
Carafoli, E. Mitochondria in the contraction and relaxation of heart. In Myocardial Biology, Vol. 4, N. S. Dhalla, ed. University Park Press, Baltimore (1974), pp. 393–406.
Carafoli, E.; and Crompton, M. The regulation of intracellular calcium. In Current Topics in Membranes and Transport, F. Bronner and A. Kleinzeller, eds. Academic Press, New York (1978a), pp. 151–216.
Carafoli, E.; and Crompton, M. The regulation of intracellular calcium by mitochondria. Ann. N.Y. Acad. Sci, 307, 269–284 (1978b).
Carafoli, E.; Tiozzo, R.; Crovetti, L. F.; and Kratzing, C. The release of calcium from heart mitochondria by sodium. J. Mol. Cell. Cardiol, 6, 361–371 (1974).
Dhalla, N. S. Defects in calcium regulatory mechanisms in heart failure. In Myocardial Biology, Vol. 4, N. S. Dhalla, ed. University Park Press, Baltimore (1974), pp. 521–534.
Dhalla, N. S. Involvement of membrane systems in heart failure due to intracellular calcium overload and deficiency. J. Mol. Cell. Cardiol., 8, 661–667 (1976).
Dhalla, N. S.; Tomlinson, C. W.; Singh, J. N.; Lee, S. L.; McNamara, D. B.; Harrow, J. A. C; and Yates, J. C. Role of sarcolemmal changes in cardiac pathophysiology. In The Sarcolemma, P. Roy and N. S. Dhalla, eds. University Park Press, Baltimore (1976), pp. 377–394.
Dhalla, N. S.; Das, P. K.; and Sharma, G. P. Subcellular basis of cardiac failure. J. Mol. Cell. Cardiol., 10, 363–385 (1978).
Dietrich, J.; and Diacono, J. Comparison between ouabain and taurine effects on isolated rat and guinea pig hearts in low calcium medium. Life Sci., 10, 499–508 (1971).
Dolara, P.; Agresti, A.; Giotti, A.; and Pasquini, G. Effect of taurine on calcium kinetics of guinea-pig heart. Eur. J. Pharm., 24, 352–358 (1973).
Guidotti, A.; Bandiani, G.; and Giotti, A. Potentiation by taurine of inotropic effect of strophanthine on guinea-pig isolated auricles. Pharm. Res. Comm., 3, 29–38 (1971).
Hui, C. W.; Drummond, M.; and Drummond, G. I. Calcium accumulation and cyclic AMP stimulated phosphorylation in plasma membrane-enriched preparations of myocardium. Arch. Biochem. Biophys., 173, 415–427 (1976).
Huxtable, R.; and Bressler, R. Taurine concentrations in congestive heart failure. Science, 184, 1187–1188 (1974).
Kagawa, Y.; and Racker, E. Partial resolution of the enzyme catalyzing oxidative phosphorylation. J. Biol. Chem., 246, 5477–5490 (1971).
Katz, A. M. Congestive heart failure: Role of altered myocardial cellular control. N. Engl. J. Med., 293, 1184–1191 (1975).
Katz, A. M.; Repke, D. I.; Upshaw, J. E.; and Polascik, M. A. Use of zonal centrifugation to fractionate fragmental sarcoplasmic reticulum, (Na+-K+)-activated ATPase and mitochondrial fragments. Biochim. Biophys. Acta, 205, 473–490 (1970).
Kramer, C. Y. Extension of multiple range tests to group means with unequal numbers of replication. Biometrics, 12, 307–310 (1956).
Kulakowski, E. C; Maturo, J.; and Schaffer, S. W. The identification of taurine receptors from rat heart sarcolemma. Biochem. Biophys. Res. Comm., 80, 936–941 (1978).
Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; and Randall, R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265–275 (1951).
McBroom, M. J.; and Welty, J. D. Effects of taurine on heart calcium in the cardiomyopathic hamster. J. Mol. Cell. Cardiol., 9, 853–858 (1977).
McNamara, D. B.; Sulakhe, P. V.; Singh, J. N.; and Dhalla, N. S. Properties of heart sarcolemmal Na+-K+ ATPase. J. Biochem., 75, 795–803 (1974).
Nadkarni, B. B.; Hunt, B.; and Heggtveit, H. A. Early ultrastructure and biochemical changes in myopathic hamster heart. In Myocardiology, Vol. 1, E. Bajusz and G. Rona, eds. University Park Press, Baltimore (1972), pp. 251–261.
Nayler, W. G. Significance of calcium ions in cardiac excitation and contraction. Am. Heart J., 65,404–411 (1963).
Olson, R. E. Myocardial metabolism in congestive heart failure. J. Chronic Diseases, 9, 442–464 (1959).
Peng, C. F.; Kane, J. J.; Murphy, M. L.; and Straub, K. D. Abnormal mitochondrial oxidative phosphorylation of ischemic myocardium reversed by Ca+2 chelating agents. J. Mol. Cell. Cardiol, 9, 897–908 (1977).
Peterson, M. B.; Mead, R. J.; and Welty, J. D. Free amino acids in congestive heart failure. J. Mol. Cell. Cardiol., 5, 139–147 (1973).
Racker, E.; Knowles, A. F.; and Eytan, E. Resolution and reconstitution of ion transport systems. Ann. N.Y. Acad. Sci., 264, 17–33 (1975).
Read, W. O.; and Welty, J. D. Effect of taurine on epinephrine and digoxin induced irregularities of the dog heart. J. Pharm. Exptl. Ther., 139, 283–289 (1963).
Reuter, H. Exchange of calcium ions in the mammalian myocardium: Mechanisms and physiological significance. Circ. Res., 34, 599–605 (1974).
Reynafarje, B.; and Lehninger, A. L. High affinity and low affinity binding of calcium by rat liver mitochondria. J. Biol. Chem., 244, 584–593 (1969).
St. Louis, P. J.; and Sulakhe, P. V. Adenosine triphosphate-dependent calcium binding and accumulation by guinea pig cardiac sarcolemma. Can. J. Biochem., 54, 946–956 (1976).
Selwyn, H. J.; Dawson, A. P.; and Dunnett, S. J. Calcium transport in mitochondria. FEBS Letters, 10, 1–5 (1970).
Sonnenblick, E. H.; and Stam, A. C, Jr. Cardiac muscle: Activation and contraction. Ann. Rev. Physiol, 31, 647–674 (1969).
Sperelakis, N.; and Schneider, J. A. A metabolic control mechanism for calcium ion influx that may protect the ventricular myocardial cell. Am. J. Cardiol, 37, 1079–1085 (1976).
Sulakhe, P. V.; and Dhalla, N. A. Excitation-contraction coupling in heart: VII. Calcium accumulation in subcellular particles in congestive heart failure. J. Clin. Invest., 50, 1019–1027 (1971a).
Sulakhe, P. V.; and Dhalla, N. S. VI. Demonstration of calcium activated ATPase in the dog heart sarcolemma. Life Sci, 10, 185–191 (1971b).
Sulakhe, P. V.; Leung, N. L.; and St. Louis, P. J. Stimulation of calcium accumulation in cardiac sarcolemma by protein kinase. Can. J. Biochem., 54, 438–445 (1976).
Taussky, H. H.; and Shorr, E. A microcolorimetric method for the determination of inorganic phosphorus. J. Biol. Chem., 202, 675–685 (1953).
Tomlinson, C. W.; Yates, J. C; and Dhalla, N. S. Relationship among changes in intracellular calcium stores, ultrastructure and contractility of myocardium. In Myocardial Biology, Vol. 4, N. S, Dhalla, ed. University Park Press, Baltimore (1974), pp. 331–345.
Welty, J. D.; and Read, W. O. Studies on some cardiac effects of taurine. J. Pharm. Exptl. Ther., 144, 110–155 (1964).
Welty, J. D.; McBroom, M. J.; Appelt, A. W.; Peterson M. B.; and Read, W. O. Effect of taurine on heart and brain electrolyte imbalances. In Taurine, R. Huxtable and A. Barbeau, eds. Raven Press, New York (1976), pp. 155–163.
Wollenberger, A. The energy metabolism of the failing heart and the metabolic action of the cardiac glycosides. J. Pharm. Exptl Ther., 97, 311–352 (1949).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Spectrum Publications, Inc.
About this chapter
Cite this chapter
Welty, J.D., Welty, M.C. (1981). Effects of Taurine on Subcellular Calcium Dynamics in the Normal and Cardiomyopathic Hamster Heart. In: Schaffer, S.W., Baskin, S.I., Kocsis, J.J. (eds) The Effects of Taurine on Excitable Tissues. Monographs of the Physiological Society of Philadelphia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8093-8_22
Download citation
DOI: https://doi.org/10.1007/978-94-009-8093-8_22
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-8095-2
Online ISBN: 978-94-009-8093-8
eBook Packages: Springer Book Archive