Summary
PACAP is a pleiotropic peptide and is well known to suppress neuronal cell death after ischemic injury through PACAP specific receptor (PAC1R). However, the pathological role of PAC1R is not elicited well on traumatic injured brain. Therefore, the purpose of this study is to investigate the expression and localization of PAC1R after traumatic brain injury (TBI) with immunohistochemistry. The PAC1R-immunoreactions (ir) were detected in peri-contusional area 3h after TBI and gradually increased up to 7d. Double immunohistochemical studies were revealed that the PAC1R-ir were co-localized with a microglial marker, CD11b. At 7d after TBI, the PAC1R-ir were merged with CD11b and with GFAP, an astroglial marker. These results suggested that PAC1R expresses in microglia and astrocyte with different time points after TBI, and PACAP and its receptor might play an important role for brain injury as well as ischemia.
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Morikawa, K. et al. (2009). Expression and localization of pituitary adenylate cyclase-activating polypeptide (PACAP) specific receptor (PAC1R) after traumatic brain injury in mice. In: Shioda, S., Homma, I., Kato, N. (eds) Transmitters and Modulators in Health and Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99039-0_19
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DOI: https://doi.org/10.1007/978-4-431-99039-0_19
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-99038-3
Online ISBN: 978-4-431-99039-0
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