Abstract
Afamin, an 87kDa human plasma glycoprotein with specific binding properties for vitamin E (a-tocopherol) was recently characterized ([Jerkovic, 1997]; [Vögele, 1999]). In the present study the in vitro effects on neuronal cells of native human Afamin, of Afamin pre-loaded with vitamin E (Afamin+), and of vitamin E were investigated. Isolated cortical chicken neurons were maintained either under apoptosis-inducing low serum conditions or exposed to oxidative stress by the addition of H2O2 or beta-amyloid peptide25–35. Afamin and vitamin E synergistically enhance the survival of cortical neurons under apoptotic conditions. Furthermore, Afamin alone protects cortical neurons from cell death in both experimental settings. Therefore, the plasma glycoprotein Afamin apparently displays a neuroprotective activity not only by virtue of binding and transporting vitamin E but also on its own.
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Heiser, M. et al. (2002). Vitamin E binding protein A famin Protects Neuronal Cells in vitro . In: Jellinger, K.A., Schmidt, R., Windisch, M. (eds) Ageing and Dementia Current and Future Concepts. Journal of Neural Transmission. Supplementa, vol 62. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6139-5_32
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DOI: https://doi.org/10.1007/978-3-7091-6139-5_32
Publisher Name: Springer, Vienna
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