Abstract
The scaffold with exact shape and polygradient inner structure was necessary for bone tissue engineering scaffolds to facilitate cells infiltration and proliferation. A novel method of designing and preparing bone tissue engineering scaffolds with polygradient controllable structure of both macro and micro pores was proposed in this paper. By integrating rapid prototyping and freeze drying technology, the macro and micro pores were formed respectively. The size, shape and quantity of micropores were controlled by slurry concentration. The sintered β-TCP porous scaffolds were with connective macropores of approximately 400µm and micropores of 50∼300µm. The chemical composition, porosity and mechanical properties of scaffolds were measured and analyzed. The detected results indicated that the β-TCP scaffolds could fulfill the requirements of tissue engineering.
Access provided by Autonomous University of Puebla. Download to read the full chapter text
Chapter PDF
Similar content being viewed by others
References
K.H. Tan, C.K. Chua, K.F. Leong, C.M. Cheah. (2005) Scaffold development using selective laser sintering polyetheretherketone-hydroxyapatite biocomposite blends. Biomaterials 26: 4281–4289
SF Yang, KF Leong, ZH Du, CK Chua. (2001) The design of scaffolds for use in tissue engineering: Part 1-Traditional factors. Tissue Engineering 7(6): 679–690
Wu Linbo, Ding Jiandong. (2005) Compression Molding of PCL Porous Scaffolds with complicated shape for Tissue Engineering, Polymer Material Science and Engineering Vol. 25 No.1: 296–299
A. Woesz, M. Rumpler, J. Stampfl, F. Varga. (2005) Towards bone replacement materials from calcium phosphates via rapid prototyping and ceramic gelcasting, Materials Science and Engineering C 25: 181–186
Li Xiang, Li Dichen, Su Yanping, lu Bingheng, (2005) Structure Design and Fabrication of B-ricalcium Phosphate Artificial Bone Based on Rapid Prototyping Technique, Journal of Xi’an Jiantong University Vol. 39 No. 1: 13–16
Shi Pujiang, Li Yubao, Zhang Li. (2006) Fabrication and characterization of n-HA/CS porous scaffold containing ALG/CS microspheres, Journal of Functional Materials Vol. 37: 1798–1800
Sylvain Deville, Eduardo Saiz, Antoni P. Tomsia.(2006) Freeze casting of hydroxyapatite scaffolds for bone tissue engineering, Biomaterials 27: 5480–5489
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Lin, L., Ju, S., Cen, L., Zhang, H., Hu, Q. (2008). Fabrication of porous β-TCP scaffolds by combination of rapid prototyping and freeze drying technology. In: Peng, Y., Weng, X. (eds) 7th Asian-Pacific Conference on Medical and Biological Engineering. IFMBE Proceedings, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79039-6_24
Download citation
DOI: https://doi.org/10.1007/978-3-540-79039-6_24
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-79038-9
Online ISBN: 978-3-540-79039-6
eBook Packages: EngineeringEngineering (R0)