Summary
The polyamine, spermine, if ionophoretically injected into identified molluscan neurons, reduces the amplitude of action potentials and alters their wave form. Spermine cations block both, the calcium inward current and the delayed potassium outward current in a dose dependent manner. The block of the ionic currents by spermine cations can be described as a voltage dependent reaction.
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References
Drouin, H. (1983) In: Membrane Permeability: Experiments and Models. (A.H. Bretag, Ed.), Techsearch Inc., Adelaide, South Australia, pp. 89–96.
Drouin, H. (1984) Biophys. J. 46, 597–604.
Drouin, H. & A., Hermann, (1984) Ann. NY. Acad.Sci., 534–536.
Gilad, G.M. & VH.,Gilad,(1988) Dev. Brain Res. 38, 175–181.
Gorman, A.L.F. & A., Hermann(1982) J. Physiol. (Lond.) 333, 681–699.
Gould, R.M. & GA., Cottrell, (1974) Comp. Biochem. Physiol. 48B, 591–597.
Hermann, A. & A.L.F., Gorman (1981) J. Gen. Physiol. 78, 63–86.
Kandel, E.R. (1976) In: Cellular Basis of Behavior. Freeman.
Kostyuk, P.G., Mironov, S.L. & P.A., Doroshenko (1982) J. Membrane Biol. 70, 181–189.
Kremzner, L.T. & R.T., Ambron (1982) J. Neurochem. 38, 1719–1727.
Miller, C. (1982) J. Gen. Physiol. 79, 869–891.
Pajunen, A.E.I., Hietala, O.A., Virransalo, E.L. & R.S., Piha (1978) J. Neurochem. 30, 281–283.
Schuber, F. (1989) Biochem. J. 260, 1–10.
Slotkin, T.A. & J., Bartolome (1986) Brain Res. Bull. 17, 307–320.
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© 1990 Birkhäuser Verlag Basel
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Drouin, H., Hermann, A. (1990). Intracellular Spermine Modifies Neuronal Electrical Activity. In: Vasilescu, D., Jaz, J., Packer, L., Pullman, B. (eds) Water and Ions in Biomolecular Systems. Advances in Life Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7253-9_21
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DOI: https://doi.org/10.1007/978-3-0348-7253-9_21
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