Abstract
The ability to accurately mimic normal processes for sensitization and allergen challenge in an experimental animal model are useful in that they allow researchers to critically manipulate the complex interactions of multiple cell types. In the context of the allergic lung, multiple cell types form complex cellular networks and function to regulate a variety of temporal and spatial changes. Mouse models of allergic airway disease have proven to be highly useful for dissecting these complex interactions, particularly in addressing remodeling of the allergic airway in chronic asthma. Until we can better represent the normal processes that initiate and perpetuate asthma, our understanding of the mechanisms of tissue injury leading to chronic remodeling of the airways and effective therapeutic strategies to treat this disease will remain limited. It was with this goal in mind that we set about devising an inhalational model of Aspergillus fumigatus-induced fungal asthma in a murine experimental system.
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Acknowledgments
This work was supported by NIH grant 1R15AI69061 to J.M.S. and an NIH Center grant 2P20RR015566 to Sibi. Core Biology Facilities and microscopy through the Advanced Imaging and Microscopy laboratory at NDSU were funded through grants 2P20RR015566 to Sibi and NSF MRI-R2 DBI-0959512 to Grazul-Bilska, respectively. The authors would also like to acknowledge the outstanding undergraduate, graduate, and postdoctoral trainees who have contributed their effort, intellect, and enthusiasm to this project.
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Schuh, J.M., Hoselton, S.A. (2013). An Inhalation Model of Allergic Fungal Asthma: Aspergillus fumigatus-Induced Inflammation and Remodeling in Allergic Airway Disease. In: Allen, I. (eds) Mouse Models of Allergic Disease. Methods in Molecular Biology, vol 1032. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-496-8_14
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DOI: https://doi.org/10.1007/978-1-62703-496-8_14
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