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An In Vivo Compression Model of Spinal Cord Injury

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Neurotrophic Factors

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1727))

Abstract

Animal spinal cord injury (SCI) models have proven highly useful for investigating the mechanisms involved in the injury process and evaluating the effectiveness of experimental therapeutic interventions. Over the last years, substantial improvements have been made in producing consistent and reproducible animal SCI models. Different SCI models have been developed to address the mechanism of injury, being divided into contusion, compression, distraction, dislocation, transection, or chemical models. The method described here is a mouse compression model of SCI that, in many respects, faithfully reproduces SCI in man.

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Authors and Affiliations

  1. Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Messina, Italy

    Irene Paterniti, Emanuela Esposito & Salvatore Cuzzocrea

Authors
  1. Irene Paterniti
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  2. Emanuela Esposito
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  3. Salvatore Cuzzocrea
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Corresponding author

Correspondence to Salvatore Cuzzocrea .

Editor information

Editors and Affiliations

  1. Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy

    Stephen D. Skaper

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Paterniti, I., Esposito, E., Cuzzocrea, S. (2018). An In Vivo Compression Model of Spinal Cord Injury. In: Skaper, S. (eds) Neurotrophic Factors. Methods in Molecular Biology, vol 1727. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7571-6_29

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  • DOI: https://doi.org/10.1007/978-1-4939-7571-6_29

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7570-9

  • Online ISBN: 978-1-4939-7571-6

  • eBook Packages: Springer Protocols

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