Summary
This study elucidated the effect of taurine on fatty liver in simple obesity. Taurine was orally administered to 10 children with fatty liver. During taurine administration, the CT numbers of the liver, which were low in the beginning, increased. Serum ALT levels were improved, especially in those children whose weight was well controlled. Even in those who failed in weight control, serum ALT levels were slightly recovered. Ratios of glycine/taurine-conjugated bile acids were decreased. Thus, taurine was effective in treating fatty liver of children with simple obesity regardless of the success/failure of weight control. Taurine administration is considered to be helpful as an adjuvant therapy for fatty liver.
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References
Adler, M. and Schaffner, F. 1979, Fatty liver hepatitis and cirrhosis in obese patients, Am.J.Med. 67:811–816.
Gaull, G.E. 1989, Taurine in pediatric nutrition: Review and update, Pediatrics, 83:433–442.
Hayashi, M. 1990, The effect of taurine on experimental fatty degeneration in primary cultured rat hepatocytes, Act.Hepatol.Jpn. 31:75–80.
Kato, K., Takayama, T., Katada, N., Nishimura, D., Shibata, T., and Takeichi, M. 1980, Evaluation of computed tomography in the diagnosis of liver diseases, Acta.Hepatol.Jpn. 21:58–69.
Kendler, B.S. 1989, Taurine: an overview of its role in preventive medicine, Preventive Med. 18:100
Matsuyama, Y., Morita, T., Higuchi, M., and Tsujii, T. 1983, The effect of taurine administration on patients with acute hepatitis, in: “Sulfur Amino Acids: Biochemical and Clinical Aspects”, Kuriyama, K., Huxtable, R.J. and Iwata, H. eds., Alan R. Liss, Inc., New York, pp. 461–468.
Nakamura-Yamanaka, Y., Tsuji, K., and Ichikawa, T. 1987, Effect of dietary taurine on cholesterol 7α-hydroxylase activity in the liver of mice fed a lithogenic diet, J.Nutr.Sci. Vitaminol. 33:239–243.
Nakashima, T., Takino, T., and Kuriyama, K. 1983, Therapeutic and prophylactic effects of taurine administration on experimental liver injury, in: “Sulfur Amino Acids: Biochemical and Clinical Aspects”, Kuriyama, K., Huxtable, R.J. and Iwata, H. eds., Alan R. Liss, Inc., New York, pp. 449–460.
Okamoto, E., Rassin, D.K., Zucker, C.L., Salen, G.S., and Heird, W.C. 1984, Role of taurine in feeding the low birth weight infant, J.Peds. 104:936–940.
Yan, C.C., Bravo, E., and Cantafora, A. 1993, Effect of taurine levels on liver lipid metabolism: an in vivo study in the rat, Proc.Soc.Exp.Biol.Med. 202:88–96.
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© 1996 Springer Science+Business Media New York
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Obinata, K., Maruyama, T., Hayashi, M., Watanabe, T., Nittono, H. (1996). Effect of Taurine on the Fatty Liver of Children with Simple Obesity. In: Huxtable, R.J., Azuma, J., Kuriyama, K., Nakagawa, M., Baba, A. (eds) Taurine 2. Advances in Experimental Medicine and Biology, vol 403. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0182-8_67
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DOI: https://doi.org/10.1007/978-1-4899-0182-8_67
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