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Germ Cell Tumors of the Ovary

  • Chapter
Blaustein’s Pathology of the Female Genital Tract

Abstract

This group of ovarian neoplasms is composed of a number of histologically different tumor types and embraces all the neoplasms considered to be ultimately derived from the primitive germ cells of the embryonic gonad. The concept of germ cell tumors as a specific group of gonadal neoplasms has evolved in the last three decades. It is based on (1) the common histogenesis of these neoplasms, (2) the relatively frequent presence of histologically different neoplastic elements within the same tumor mass, and (3) the presence of histologically similar neoplasms in extragonadal locations along the line of migration of the primitive germ cells from the wall of the yolk sac to the gonadal ridge,332 as well as on the remarkable homology between the various tumors in the male and the female.

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References

  1. Abbot TM, Herman WJ Jr, Scully RE (1984) Ovarian fetiform teratoma (homunculus) in a 9-year-old girl. Int J Gynecol Pathol 2: 392

    Article  Google Scholar 

  2. Abell MR, Johnson VJ, Holtz F (1965) Ovarian neoplasms in childhood and adolescence. Part 1. Tumors of germ cell origin. Am J Obstet Gynecol 92: 1059

    Google Scholar 

  3. Abitol MM, Pomerance W, Mackles A (1959) Spontaneous intraperitoneal rupture of benign cystic teratomas. Review of literature and report of two cases. Obstet Gynecol 13: 198

    Google Scholar 

  4. Afridi MA, Vongtama V, Tsukada Y, Piver MS (1976) Dysgerminoma of the ovary. Radiation therapy for recurrence and metastases. Am J Obstet Gynecol 126: 190

    Google Scholar 

  5. Aguirre P, Scully RE (1982) Malignant neuroectodermal tumor of the ovary: A distinctive form of monodermal teratoma. Report of five cases. Am J Surg Pathol 6: 283

    Google Scholar 

  6. Albrechtsen R, Klee JG, Moller JE (1972) Primary intracranial germ cell tumours, including five cases of endodermal sinus tumour. Acta Pathol Microbiol Scand [80A Suppl] 233: 32

    CAS  Google Scholar 

  7. Allard S, Cadotte M, Boivin Y (1972) Dysgenesie gonadique pure familiale et gonadoblastome. L’Union Medicale du Canada 101: 448

    CAS  Google Scholar 

  8. Anderson CT Jr, Carlson IH (1975) Elevated plasma testosterone and gonadal tumors in two 46XY “sisters.” Arch Pathol 99: 360

    PubMed  Google Scholar 

  9. Anderson MC, McDicken IW (1971) Melanotic cyst of the ovary. J Obstet Gynaecol Br Commw 78: 1047

    Article  CAS  Google Scholar 

  10. Ansfield FJ, Korbitz BC, Davis HL, Ramirez G (1969) Triple drug therapy in testicular tumors. Cancer 24: 442

    Article  PubMed  CAS  Google Scholar 

  11. Arhelger RB, Kelly B (1974) Strumal carcinoid. Report of a case with electron microscopical observations. Arch Pathol 97: 323

    Google Scholar 

  12. Asadourian LA, Taylor HB (1969) Dysgerminoma. An analysis of 105 cases. Obstet Gynecol 33: 370

    PubMed  CAS  Google Scholar 

  13. Awais GA (1983) Dysgerminoma and serum lactic dehydrogenase levels. Obstet Gynecol 61: 99

    PubMed  CAS  Google Scholar 

  14. Azoury RS, Jubayli NW, Barakat BY (1973) Dermoid cyst of the ovary containing fetus-like structure. Obstet Gynecol 42: 887

    PubMed  CAS  Google Scholar 

  15. Bagg HJ (1936) Experimental production of teratoma testis in a fowl. Am J Cancer 26: 69

    Google Scholar 

  16. Ballas M (1972) Yolk sac carcinoma of the ovary with alpha-fetoprotein in serum and ascitic fluid demonstrated by immunoosmophoresis. Am J Clin Pathol 57: 511

    PubMed  CAS  Google Scholar 

  17. Ballas M (1974) The significance of alpha-fetoprotein in the serum of patients with malignant teratomas and related gonadal neoplasms. Am J Clin Lab Sci 4: 267

    CAS  Google Scholar 

  18. Bardin CW, Rosen S, Le Maire WJ, Tjio JH, Gallup J, Marshall J, Savard K (1968) In vivo and in vitro studies of androgen metabolism in a patient with pure gonadal dysgenesis and Leydig cell hyperplasia. J Clin Endocrinol Metab 29: 1429

    Article  Google Scholar 

  19. Barry KG, Crosby WH (1957) Autoimmune hemolytic anemia arrested by removal of ovarian teratoma: Review of the literature and report of a case. Ann Int Med 47: 1002

    Google Scholar 

  20. Bartlett DJ, Grant JK, Pugh MA, Aherne W (1968) A familial feminizing syndrome. A family showing intersex characteristics with XY chromosomes in three female members. J Obstet Gynaecol Br Commw 75: 199

    Google Scholar 

  21. Battifora H, Sheibani K, Tubbs RR, Kopinski MI, Sun TT (1984) Antikeratin antibodies in tumor diagnosis. Distinction between seminoma and embryonal carcinoma. Cancer 54: 843

    Google Scholar 

  22. Beck JS, Fulmer HF, Lee ST (1969) Solid malignant ovarian teratoma with “embryoid bodies” and trophoblastic differentiation. J Pathol 99: 67

    Article  PubMed  CAS  Google Scholar 

  23. Beilby JOW, Todd PJ (1974) Yolk sac tumour of the ovary. J Obstet Gynaecol Br Commw 81: 90

    Article  CAS  Google Scholar 

  24. Berg JW, Baylor SM (1973) The epidemiologic pathology of ovarian cancer. Hum Pathol 4: 537

    Article  PubMed  CAS  Google Scholar 

  25. Bergher de Bacalao E, Dominguez I (1969) Unilateral gonadoblastoma in a pregnant woman. Am J Obstet Gynecol 105: 1279

    Google Scholar 

  26. Bergstrand CG, Czar B (1956) Demonstration of a new protein fraction in serum from human fetus. Scand J Lab Invest 8: 174

    Article  CAS  Google Scholar 

  27. Bernstein D, Naor S, Rikover M, Manahem H (1974) Hemolytic anemia related to ovarian tumor. Obstet Gynecol 43: 276

    PubMed  CAS  Google Scholar 

  28. Bestle J (1968) Extragonadal endodermal sinus tumours originating in the region of the pineal gland. Acta Pathol Microbiol Scand 74: 214

    Article  PubMed  CAS  Google Scholar 

  29. Bettinger HF, Jacobs H (1948) Mesonephroma ovarii. Med J Aust 1: 100

    PubMed  CAS  Google Scholar 

  30. Blackwell WJ, Dockerty MB, Masson JC, Mussey RD (1946) Dermoid cysts of the ovary; clinical and pathological significance. Am J Obstet Gynecol 51: 151

    PubMed  CAS  Google Scholar 

  31. Boczkowski K, Teter J, Sternadel Z (1972) Sibship occurrence of XY gonadal dysgenesis with dysgerminoma. Am J Obstet Gynecol 113: 952

    PubMed  CAS  Google Scholar 

  32. Borushek S, Berger I, Echt C, Gold JJ (1965) Functioning malignant germ cell tumor of the ovary in a 41/2 year old girl. Cancer 18: 1485

    Article  PubMed  CAS  Google Scholar 

  33. Bradof JE, Hakes TB, Ochoa M, Golbey R (1982) Germ cell malignancies of the ovary. Treatment with vinblastine, actinomycin D, bleomycin and cisplatin containing chemotherapy combinations. Cancer 50: 1070

    Google Scholar 

  34. Braunstein H, Stephens CL, Gibson RL (1968) Secretory granules in medullary carcinoma of the thyroid. Electron microscopic demonstration. Arch Pathol 85: 306

    Google Scholar 

  35. Breen JL, Maxson WS (1977) Ovarian tumors in children and adolescents. Clin Obstet Gynecol 20: 607

    Article  PubMed  CAS  Google Scholar 

  36. Breen JL, Neubecker RD (1963) Malignant teratoma of the ovary. An analysis of 17 cases. Obstet Gynecol 21: 669

    PubMed  CAS  Google Scholar 

  37. Breen JL, Neubecker RD (1967) Ovarian malignancy in children with special reference to the germ cell tumors. Ann NY Acad Sci 142: 658

    Article  PubMed  CAS  Google Scholar 

  38. Brody S (1961) Clinical aspects of dysgerminoma of the ovary. Acta Radiol (Stockholm) 56: 209

    Article  CAS  Google Scholar 

  39. Brown JR, Green JD (1976) Yolk sac carcinoma. South Med J 69: 728

    Article  PubMed  CAS  Google Scholar 

  40. Burkons DM, Hart WR (1978) Ovarian germinomas (dysgerminomas). Obstet Gynecol 51: 221

    PubMed  CAS  Google Scholar 

  41. Cabanne F (1971) Gonadoblastomes et tumerus de l’ebauche gonadique. Ann Anat Pathol (Paris) 16: 387

    CAS  Google Scholar 

  42. Carleton RL, Friedman NB, Bomze EJ (1953) Experimental teratomas of testis. Cancer 6: 464

    Article  PubMed  CAS  Google Scholar 

  43. Caruso PA, Marsh MR, Minkowitz S, Karten G (1971) An intense clinicopathologic study of 305 teratomas of the ovary. Cancer 27: 343

    Article  PubMed  CAS  Google Scholar 

  44. Chenot M (1911) Contribution à l’étude des épithéliomas primitifs de l’ovaire. Thesis, Paris

    Google Scholar 

  45. Chevassu M (1906) Tumeurs du Testicule. Thesis, Steinhall Paris

    Google Scholar 

  46. Chretien PB, Milam JD, Foote FW, Miller TR (1970) Embryonal adenocarcinomas (a type of malignant teratoma) of the sacrococcygeal region. Clinical and pathologic aspects of 21 cases. Cancer 26: 522

    Article  PubMed  CAS  Google Scholar 

  47. Chumas JC, Rosenwaks Z, Mann JW, Finkel G, Pastore J (1984) Sertoli-Leydig cell tumor of the ovary producing alpha-fetoprotein. Int J Gynecol Pathol 3: 213

    Article  PubMed  CAS  Google Scholar 

  48. Climie AR, Heath LP (1968) Malignant degeneration of benign cystic teratoma of the ovary. Review of the literature and report of a chondrosarcoma and a carcinoid tumor. Cancer 22: 824

    Google Scholar 

  49. Collins DH, Symington T (1965) Sertoli cell tumour. In: Collins DH, Pugh RCB (eds) The pathology of testicular tumours. Edinburgh and London, Livingstone Ltd., pp 52–61

    Google Scholar 

  50. Cooperman LR, Hamlin J, Elmer N (1968) Gonadoblastoma: A rare ovarian tumor with characteristic roentgen appearance. Radiology 90: 322

    Google Scholar 

  51. Corfman PA, Richart RM (1964) Chromosome number and morphology of benign cystic teratomas. N Engl J Med 271: 1241

    Article  PubMed  CAS  Google Scholar 

  52. Cutler BS, Forbes AP, Ingersoll FM, Scully RE (1972) Endometrial carcinoma after stilbestrol therapy in gonadal dysgenesis. N Engl J Med 287: 628

    Article  PubMed  CAS  Google Scholar 

  53. Dalgaard JB, Wetteland P (1956) Struma ovarii. A follow-up study of 20 cases. Acta Chir Scand 112: 1

    PubMed  CAS  Google Scholar 

  54. Damjanov I, Drobnjak P, Grizelj V (1975). Ultrastructure of gonadoblastoma. Arch Pathol 99: 25

    PubMed  CAS  Google Scholar 

  55. Dandia SD (1967) Rectovesical fistula following an ovarian dermoid with recurrent vesical calculus. A case report. J Urol 97: 85

    PubMed  CAS  Google Scholar 

  56. Davidsohn I, Kovarik S, Stejskal R (1968) Immunological aspects. Influence of prognosis and treatment. In: Gentil F, Junqueira AC (eds) Ovarian cancer U.I. C.C. Monograph Series, Vol 11. Berlin, Heidelberg, New York, Springer-Verlag, pp 105–121

    Chapter  Google Scholar 

  57. Dawson MA, Wilimer T, Yarbro JW (1971) Hemolytic anemia associated with an ovarian tumor. Am J Med 50: 552

    Article  PubMed  CAS  Google Scholar 

  58. Dayal Y, Tashjian AH Jr, Wolfe HJ (1979) Immunocytochemical localization ofcalcitonin-producing cells in a strumal carcinoid with amyloid stroma. Cancer 43: 1331

    Article  PubMed  CAS  Google Scholar 

  59. De Haan QC (1965) Non-gestational choriocarcinoma of the ovary. Obstet Gynecol 26: 708

    Google Scholar 

  60. De Lima FAO (1966) Disgerminoma do Ovario, contribucao para o seo estudo anatomo-clinico. Thesis, Sao Paulo, Brazil

    Google Scholar 

  61. Dikman SH, Toker C (1971) Strumal carcinoid of the ovary with musculinization. Cancer 27: 925

    Article  PubMed  CAS  Google Scholar 

  62. Diligent E (1971) Gonadoblastomes et dysgenesies pseudogonadoblastiques. Thesis. Nancy

    Google Scholar 

  63. Dixon FJ, Moore RA (1952) Tumors of the male sex organs. Atlas of Tumor Pathology, Sect VIII, Fasc 31b and 32. Washington, D.C., Armed Forces Institute of Pathology

    Google Scholar 

  64. Duhig JT (1959) An unusual adenocarcinoma of the ovary. A case simulating Schiller’s mesonephroma. Am J Obstet Gynecol 77: 201

    PubMed  CAS  Google Scholar 

  65. Duval M (1891) Le placenta de rongeurs. J Anat Physiol (Paris) 27: 515

    Google Scholar 

  66. Einhorn LH, Donohue J (1977) Cisdiammine dichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Intern Med 87: 293

    Article  PubMed  CAS  Google Scholar 

  67. Emge LA (1940) Functional and growth characteristics of struma ovarii. Am J Obstet Gynecol 40: 738

    CAS  Google Scholar 

  68. Engel T, Greeley AV, Sweeney WJ III (1965) Recurrent dermoid cysts of the ovary. Report of 2 cases. Obstet Gynecol 26: 757

    PubMed  CAS  Google Scholar 

  69. Erez SE, Richart RM, Shettles LB (1965) Hashimoto’s disease in a benign cystic teratoma of the ovary. Am J Obstet Gynecol 92: 273

    PubMed  CAS  Google Scholar 

  70. Evans RW (1957) Developmental stages of embryo-like bodies in teratoma testis. J Clin Pathol 10: 321

    Article  Google Scholar 

  71. Evans RW (1966) Histological appearances of tumours, 2nd ed. Edinburgh and London, Livingstone

    Google Scholar 

  72. Ewing J (1940) Neoplastic diseases, 4th ed. Philadelphia, Saunders, pp 641, 672

    Google Scholar 

  73. Felmus LB, Pedowitz P (1968) Clinical malignancy of endocrine tumors of the ovary and dysgerminoma. Obstet Gynecol 29: 344

    Google Scholar 

  74. Flamant F, Caillou B, Pejovic MH, Gerard-Marchant R, Gout M, Lemerle J, Sarrazin D, Zucker JM, Schweisguth 0 (1978) Prognostic factors in malignant germ cell tumors of the ovary in children excluding pure dysgerminoma. Eur J Cancer 14: 901

    CAS  Google Scholar 

  75. Forney JP, Di Saia PJ, Morrow CP (1975) Endodermal sinus tumor. A report of two sustained remissions treated postoperatively with a combination of actinomycin D, 5-fluorouracil and cyclophosphamide. Obstet Gynecol 45: 186

    PubMed  CAS  Google Scholar 

  76. Fox H, Langley FA (1976) Tumours of the ovary. London, William Heinemann Medical Books

    Google Scholar 

  77. Fox H, Kazzaz B, Langley FA (1964) Argyrophil and argentaffin cells in the female genital tract and in ovarian mucinous cysts. J Pathol Bacteriol 88: 479

    Article  PubMed  CAS  Google Scholar 

  78. Frazier SD, Bashore RA, Mosier HD (1964) Gonadoblastoma associated with pure gonadal dysgenesis in monozygous twins. J Pediatr 64: 740

    Article  Google Scholar 

  79. Fred JH, Cassir JF, Pierce VK, Woodruff J, Lewis JL Jr (1979) Dysgerminoma of the ovary. Cancer 43: 798

    Article  Google Scholar 

  80. Friedman NB (1951) The comparative morphogenesis of extragenital and gonadal teratoid tumors. Cancer 4: 265

    Article  PubMed  CAS  Google Scholar 

  81. Friedman NB, Moore RA (1946) Tumors of the testis. A report of 922 cases. Mil Surgeon 99: 573

    CAS  Google Scholar 

  82. Fujii S, Konishi I, Suzuki A, Okamura H, Okazaki T, Mori T (1985) Analysis of serum lactic dehydrogenase levels and its isoenzymes in ovarian dysgerminoma. Gynecol Oncol 22: 65

    Article  PubMed  CAS  Google Scholar 

  83. Galager HS, Lewis RP (1973) Sequential gonadoblastoma and choriocarcinoma. Obstet Gynecol 41: 123

    Google Scholar 

  84. Gallion H, Van Nagell JR, Powell DF, Donaldson ES, Hanson M (1979) Therapy of endodermal sinus tumor of the ovary. Am J Obstet Gynecol 135: 447

    PubMed  CAS  Google Scholar 

  85. Galton M, Benirschke K (1959) 46 chromosomes in an ovarian teratoma. Lancet 2: 761

    Google Scholar 

  86. Gans B, Bahary C, Levie B (1963) Ovarian regeneration and pregnancy following massive radiotherapy for dysgerminoma. Report of a case. Obstet Gynecol 22: 596

    Google Scholar 

  87. Garvin AJ, Pratt-Thomas HR, Spector M, Spicer SS, Williamson HO (1976) Gonadoblastoma: Histologic, ultra-structural and histochemical observations in five cases. Am J Obstet Gynecol 125: 459

    Google Scholar 

  88. Gershenson DM, Del Junco G, Herson J, Rutledge FN (1983) Endodermal sinus tumor of the ovary. The M.D. Anderson experience. Obstet Gynecol 61: 194

    Google Scholar 

  89. Gershenson DM, Copeland LJ, Kavanagh JJ, Cangir A, Del Junco G, Saul PB, Stringer CA, Freedman RS, Edwards CL, Wharton JT (1985) Treatment of malignant nondysgerminomatous germ cell tumors of the ovary with vincristine, dactinomycin and cyclophosphamide. Cancer 56: 2756

    Article  PubMed  CAS  Google Scholar 

  90. Gillman J (1948) The development of the gonads in man with consideration of the role of fetal endocrines and the histogenesis of ovarian tumors. Contrib Embryol 32: 83

    Google Scholar 

  91. Gitlin D, Boesman M (1967) Sites of serum alpha-fetoprotein synthesis in the human and in the rat. J Clin Invest 46: 1010

    Article  PubMed  CAS  Google Scholar 

  92. Gitlin D, Pericelli A (1970) Synthesis of serum albumin, prealbumin, alpha-fetoprotein, alpha-l-antitrypsin and transferrin by the human yolk sac. Nature 228: 995

    Article  PubMed  CAS  Google Scholar 

  93. Gitlin D, Pericelli A, Gitlin G (1972) Synthesis of alphafetoprotein by liver, yolk sac and gastrointestinal tract of the human conceptus. Cancer Res 32: 979

    PubMed  CAS  Google Scholar 

  94. Goldsmith CI, Hart WR (1975) Ataxia-telangiectasia with ovarian gonadoblastoma and contralateral dysgerminoma. Cancer 36: 1838

    Google Scholar 

  95. Goldstein DP, Piro JA (1972) Combination chemotherapy in the treatment of germ cell tumors containing choriocarcinoma. Surg Gynecol Obstet 134: 61

    PubMed  CAS  Google Scholar 

  96. Gondos B, Bhiraleus P, Hobel CJ (1971) Ultrastructural observations on germ cells in human fetal ovaries. Am J Obstet Gynecol 110: 644

    PubMed  CAS  Google Scholar 

  97. Gonzalez-Angulo A, Kaufman R, Braungardt CD, Chapman FC, Hinshaw AJ (1963) Adenocarcinoma of thyroid arising in struma ovarii (malignant struma ovarii). Report of two cases and review of the literature. Obstet Gynecol 21: 567.

    Google Scholar 

  98. Gonzalez-Crussi F, Roth LM (1976) The human yolk sac and yolk sac carcinoma. Hum Pathol 7: 675

    Article  PubMed  CAS  Google Scholar 

  99. Gonzalez-Licea A, Hartman WH, Yardley JH (1968) Medullary carcinoma of the thyroid. Ultrastructural evidence of its origin from the parafollicular cell and its possible relation to carcinoid tumors. Am J Clin Pathol 49: 512

    Google Scholar 

  100. Gordon A, Lipton D, Woodruff JD (1981) Dysgerminoma: A review of 158 cases from the Emil Novak Ovarian Tumor Registry. Obstet Gynecol 58: 497

    PubMed  CAS  Google Scholar 

  101. Greco MA, LiVolsi VA, Pertschuk LP, Bigelow B (1979) Strumal carcinoid of the ovary; an analysis of its components. Cancer 43: 1380

    Article  PubMed  CAS  Google Scholar 

  102. Griffiths K, Grant JK, Browning NCK, Whyte WG, Sharp JL (1966) Steroid synthesis in vitro by tumor tissue from dysgenetic gonad. J Endocrinol 34: 155

    Article  PubMed  CAS  Google Scholar 

  103. Grosfeld JL, Stepita DS, Nance WE, Palmer CG (1974) Fetus-in-fetu. An unusual cause for an abdominal mass in infancy. Ann Surg 180: 80

    Google Scholar 

  104. Gusberg SB, Danforth DN (1944) Clinical significance of struma ovarii. Am J Obstet Gynecol 48: 537

    Google Scholar 

  105. Hain AM (1949) An unusual case of precocious puberty associated with ovarian dysgerminoma. J Clin Endocrinol 9: 1349

    Article  CAS  Google Scholar 

  106. Hameed K, Burslem MRG (1970) A melanotic ovarian neoplasm resembling the “retinal anlage” tumor. Cancer 25: 564

    Article  PubMed  CAS  Google Scholar 

  107. Hart WR, Burkons DM (1979) Germ cell neoplasms arising in gonadoblastomas. Cancer 34: 669

    Article  Google Scholar 

  108. Hart WR, Regezi JA (1978) Strumal carcinoid of the ovary. Ultrastructural observations and long-term follow-up study. Am J Clin Pathol 69: 356

    Google Scholar 

  109. Hertig AT, Adams CE (1967) Studies on the human oocyte and its follicle. 1. Ultrastructural and histochemical observations on primordial follicle stage. J Cell Biol 34: 647

    Google Scholar 

  110. Hertig AT, Gore H (1961) Tumors of the female sex organs. Part 3. Tumors of the ovary and fallopian tube. Atlas of Tumor Pathology, Sec 9, Fasc 33. Washington D.C., Armed Forces Institute of Pathology

    Google Scholar 

  111. Higuchi K, Kato T (1958) Dysgerminoma of the ovary. J Jpn Obstet Gynecol Soc 5: 206

    Google Scholar 

  112. Hingorani V, Narula RK, Bhalla S (1963) Salmonella typhi infection in an ovarian dermoid. Report of a case. Obstet Gynecol 22: 118

    Google Scholar 

  113. Hirschfield LS, Kahn LB, Winkler B, Bochner RZ, Gib-stein AA (1985) Adenocarcinoid of the appendix presenting as bilateral Krukenberg’s tumor of the ovaries. Arch Pathol Lab Med 109: 930

    PubMed  CAS  Google Scholar 

  114. Hou-Jensen K, Kempson RL (1974) The ultrastructure of gonadoblastoma and dysgerminoma. Hum Pathol 5: 79

    Article  PubMed  CAS  Google Scholar 

  115. Hughesdon PE (1955) Two cases of struma ovarii showing the histogenesis of thyroid and thymus in ovarian teratoma. J Pathol Bacteriol 70: 35

    Article  PubMed  CAS  Google Scholar 

  116. Hughesdon PE, Kumarasamy T (1970) Mixed germ cell tumors (gonadoblastomas) in normal and dysgenetic gonads. Virchows Arch [Pathol Anat] 349: 258

    Article  CAS  Google Scholar 

  117. Huntington RW Jr., Bullock WK (1970) Yolk sac tumors of the ovary. Cancer 25: 1357

    Article  PubMed  Google Scholar 

  118. Huntington RW Jr., Bullock, WK (1970) Yolk sac tumors of extragonadal origin. Cancer 25: 1368

    Article  PubMed  Google Scholar 

  119. Huntington RW Jr., Morgenstern NL, Sargent JA, Giem RN, Richards A, Hanford KC (1963) Germinal tumors exhibiting the endodermal sinus pattern of Teilum in young children. Cancer 16: 34

    Article  PubMed  Google Scholar 

  120. Ishida T, Tagatz GE, Okagaki T (1976) Gonadoblastoma. Ultrastructural evidence of testicular origin. Cancer 37: 1770

    Google Scholar 

  121. Itoh T, Shirai T, Naka A, Matsumoto S (1974) Yolk sac tumor and alpha-fetoprotein: Clinicopathological study of four cases. Gann 65: 215

    Google Scholar 

  122. Jackson SM (1967) Ovarian dysgerminoma. Br J Radiol 40: 459

    Article  PubMed  CAS  Google Scholar 

  123. Janovski NA, Paramanandhan TL (1973) Ovarian tumors. Tumors and tumor-like conditions of the ovaries, fallopian tubes and ligaments of the uterus. Stuttgart, Georg Thieme

    Google Scholar 

  124. Jatoi AF (1959) Dysgerminoma of the ovary (a study of 23 cases). J Postgrad Med 5: 22

    Google Scholar 

  125. Jedberg H (1949) Some clinical aspects of dysgerminoma ovarii. Acta Obstet Gynecol Scand 28: 194

    Article  PubMed  CAS  Google Scholar 

  126. Jimerson GK, Woodruff JD (1977) Ovarian extraembryonal teratoma: 1. Endodermal sinus tumor. Am J Ob-stet Gynecol 127: 73

    Google Scholar 

  127. Jimerson GK, Woodruff JD (1977) Ovarian extraembryonal teratoma: 2. Endodermal sinus tumor mixed with other germ cell tumors. Am J Obstet Gynecol 127: 302

    Google Scholar 

  128. Judd HL, Scully RE, Atkins L, Neer RM, Kliman B (1970) Pure gonadal dysgenesis with progressive hirsutism. N Engl J Med 282: 881

    Article  PubMed  CAS  Google Scholar 

  129. Kawahara H (1963) Struma ovarii with ascites and hydrothorax. Am J Obstet Gynecol 85: 85

    PubMed  CAS  Google Scholar 

  130. Kay S, Silverberg SG, Schatzki PF (1972) Ultrastructure of an ovarian dysgerminoma. Report of a case featuring neurosecretory-type granules in stromal cells. Am J Clin Pathol 58: 458

    Google Scholar 

  131. Kazancigil TR, Laquer W, Ladewig P (1940) Papilloendothelioma of the ovary; report of three cases and discussion of Schiller’s “mesonephroma ovarii.” Am J Cancer 40: 199

    Google Scholar 

  132. Kelley RR, Scully RE (1961) Cancer developing in dermoid cysts of the ovary. A report of 8 cases including a carcinoid and a leiomyosarcoma. Cancer 14: 989

    Article  PubMed  CAS  Google Scholar 

  133. King ME, Mouradian JA, Micha JP, Chaganti RSK, Allen SL (1985) Immature teratoma of the ovary with predominant malignant retinal anlage tumor. A parthenogenetically derived tumor. Am J Surg Pathol 9: 221

    Google Scholar 

  134. Klein HZ (1974) Mucinous carcinoid tumor of the vermiform appendix. Cancer 33: 770

    Article  PubMed  CAS  Google Scholar 

  135. Koller O, Gjonnes H (1964) Dysgerminoma of the ovary. Acta Obstet Gynecol Scand 43: 268

    Article  PubMed  CAS  Google Scholar 

  136. Krepart G, Smith JP, Rutledge F, Declos L (1978) The treatment for dysgerminoma of the ovary. Cancer 41: 986

    Article  PubMed  CAS  Google Scholar 

  137. Krumerman MS, Chung A (1977) Squamous carcinoma arising in benign cystic teratoma of the ovary. Cancer 39: 1237

    Article  PubMed  CAS  Google Scholar 

  138. Kurman RJ, Norris HJ (1976) Endodermal sinus tumor of the ovary. A clinical and pathologic analysis of 71 cases. Cancer 38: 2404

    Article  PubMed  CAS  Google Scholar 

  139. Kurman RJ, Norris HJ (1976) Embryonal carcinoma of the ovary. A clinicopathologic entity distinct from endodermal sinus tumor resembling embryonal carcinoma of the adult testis. Cancer 38: 2420

    Google Scholar 

  140. Kurman RJ, Norris HJ (1976) Malignant mixed germ cell tumors of the ovary. A clinical and pathologic analysis of 30 cases. Obstet Gynecol 48: 579

    PubMed  CAS  Google Scholar 

  141. Lange PH, Millan JL, Stigbrand T, Vessella RL, Ruoslahti E, Fishman WH (1982) Placental alkaline phosphatase as a tumor marker for seminoma. Cancer Res 42: 3244

    PubMed  CAS  Google Scholar 

  142. Larson NE, Dockerty MB, Pratt JH (1958) Primary mixed choriocarcinoma and dysgerminoma of the ovary. Report of a case. Proc Mayo Clin 33: 341

    Google Scholar 

  143. Levine GD (1973) Primary thymic seminoma-A neoplasm ultrastructurally similar to testicular seminoma and distinct from epithelial thymoma. Cancer 31: 729

    Article  PubMed  CAS  Google Scholar 

  144. Liebert KI, Stent L (1960) Dysgerminoma of the ovary with chorionepithelioma. J Obstet Gynaecol Br Emp 77: 627

    Article  Google Scholar 

  145. Lien L (1979) Determination of serum AFP for the diagnosis and treatment of ovarian endodermal sinus tumor. Zhonghua Fuchanke Zazhi 14: 22 (in Chinese)

    CAS  Google Scholar 

  146. Linder D (1969) Gene loss in human teratomas. Proc Natl Acad Sci USA 63: 699

    Article  PubMed  CAS  Google Scholar 

  147. Linder D, Power J (1970) Further evidence for postmeiotic origin of teratomas in the human female. Ann Hum Genet 34: 21

    Article  PubMed  CAS  Google Scholar 

  148. Linder D, McCaw BK, Hecht F (1975) Parthenogenic origin of benign ovarian teratoma. N Engl J Med 292: 63

    Article  PubMed  CAS  Google Scholar 

  149. Lingeman CH (1974) Etiology of cancer of the human ovary. A review. J Natl Cancer Inst 53: 1603

    PubMed  CAS  Google Scholar 

  150. Livnat EJ, Scommegna A, Recant W, Jao W (1977) Ultra-structural observations of the so-called strumal carcinoid of the ovary. Arch Pathol Lab Med 101: 585

    PubMed  CAS  Google Scholar 

  151. Lord JM (1956) Intra-abdominal foetus in fetu. J Pathol Bacteriol 72: 627

    Article  Google Scholar 

  152. Lynn JA, Varon HH, Kingsley WB, Martin JH (1967) Ultrastructure and biochemical studies of estrogen-secreting capacity of a “non-functional” ovarian neoplasm (dysgerminoma). Am J Pathol 51: 639

    PubMed  CAS  Google Scholar 

  153. Mackay AM, Pattigrew N, Symington T, Neville AM (1974) Tumors of dysgenetic gonads (gonadoblastoma). Ultrastructural and steroidogenic aspects. Cancer 34: 1108

    Google Scholar 

  154. McCullough CD, Hardart F (1963) Neuroblastomatous transformation in a benign cystic teratoma. Obstet Gynecol 21: 259

    Google Scholar 

  155. McDonough PG, Byrd JR, Tho PT, Otken L (1976) Gona-doblastoma in a true hermaphrodite with 46XX karyotype. Obstet Gynecol 47: 355

    PubMed  CAS  Google Scholar 

  156. McDonough PG, Greenblatt RB, Byrd JR, Hastings EV (1967) Gonadoblastoma (gonocytoma III). Report of a case. Obstet Gynecol 29: 54

    Google Scholar 

  157. McKay DG, Hertig AT, Adams EC, Danziger S (1953) Histochemical observations on the germ cells of human embryos. Anat Rec 117: 201

    Article  PubMed  CAS  Google Scholar 

  158. McKay DG, Pinkerton JHM, Hertig AT, Danziger S (1961) The adult human ovary: A histochemical study. Obstet Gynecol 18: 13

    Google Scholar 

  159. Malkasian GD Jr., Symmonds RE (1964) Treatment of the unilateral encapsulated germinoma. Am J Obstet Gynecol 90: 379

    Google Scholar 

  160. Malkasian GD Jr., Dockerty MB, Symmonds RE (1967) Benign cystic teratomas. Obstet Gynecol 29: 719

    Google Scholar 

  161. Malkasian GD Jr., Symmonds RE, Dockerty MB (1965) Malignant ovarian teratomas. Report of 31 cases. Obstet Gynecol 25: 810

    Google Scholar 

  162. Malkasian GD Jr., Webb MJ, Jorgensen EO (1974) Observations on chemotherapy of granulosa cell carcinoma and malignant ovarian teratoma. Obstet Gynecol 44: 885

    Google Scholar 

  163. Marcial-Rojas RA, de Arellano RGA (1956) Malignant melanoma arising in a dermoid cyst of the ovary. Cancer 9: 523

    Article  PubMed  CAS  Google Scholar 

  164. Marin-Padilla M (1965) Origin, nature and significance of the “embryoids” of human teratomas. Virchow’s Arch [Pathol Anat] 340: 105

    Article  CAS  Google Scholar 

  165. Marrubini G (1949) Primary chorionepithelioma of the ovary. Report of two cases. Acta Obstet Gynecol Scand 28: 251

    Article  PubMed  CAS  Google Scholar 

  166. Masson P (1912) Seminomes ovariennes. Bull Soc Anat (Paris) 87: 402

    Google Scholar 

  167. Masson P (1923) Epitheliomas pflügeriens. In: Diagnostics de laboratoire. Les tumeurs. Paris, Maloine

    Google Scholar 

  168. Mathieu J, Planchu M (1950) Le prognostic et le traitement du seminome de l’ovaire. Les oestrogenes out-ils place dans le traitement du seminome en general? Lyon Chir 45: 76

    PubMed  CAS  Google Scholar 

  169. Matz MH (1961) Benign cystic teratomas of the ovary. Obstet Gynecol Sury 16: 591

    Article  CAS  Google Scholar 

  170. Melicow MM, Uson AC (1959) Dysgenetic gonadomas and other gonadal neoplasms in intersex. Cancer 12: 552

    Article  PubMed  CAS  Google Scholar 

  171. Meyer R (1931) The pathology of some special ovarian tumors and their relation to sex characteristics. Am J Obstet Gynecol 22: 697

    Google Scholar 

  172. Miettinen M, Virtanen I, Talerman A (1985) Intermediate filament proteins in human testis and testicular germ-cell tumors. Am J Pathol 120: 402

    PubMed  CAS  Google Scholar 

  173. Miettinen M, Talerman A, Wahlstrom T, Astengo-Osuna C, Virtanen I (1985) Cellular differentiation in ovarian sex cord-stromal and germ-cell tumors studied with antibodies to intermediate-filament proteins. Am J Surg Pathol 9: 640

    Article  PubMed  CAS  Google Scholar 

  174. Moertel CG, Beahrs OH, Woolner LB, Tyce GM (1965) “Malignant carcinoid syndrome” associated with noncarcinoid tumors. N Engl J Med 273: 244

    Google Scholar 

  175. Mueller CW, Topkins P, Lapp WA (1950) Dysgerminoma of the ovary. An analysis of427 cases. Am J Obstet Gynecol 60: 153

    PubMed  CAS  Google Scholar 

  176. Neigus I (1952) Ovarian dysgerminoma with chorionepithelioma. Am J Obstet Gynecol 64: 422

    Google Scholar 

  177. Neubecker RD, Breen JL (1962) Embryonal carcinoma of the ovary. Cancer 15: 546

    Article  PubMed  CAS  Google Scholar 

  178. Nielsen SNJ, Scheithauer BW, Gaffey TA (1985) Gliomatosis peritonei. Cancer 56: 2499

    Article  PubMed  CAS  Google Scholar 

  179. Nieminen I, Von Numers C, Widholm O (1964) Struma ovarii. Acta Obstet Gynecol Scand 42: 399

    Article  CAS  Google Scholar 

  180. Nogales FF Jr, Matilla A, Nogales-Ortiz F, Calera-Davidson HL (1978) Yolk sac tumors with pure and mixed poly-vesicular vitelline patterns. Hum Pathol 9: 553

    Article  PubMed  Google Scholar 

  181. Nogales FF Jr, Silverberg SG, Bloustein PA, Martinez-Hernandez A, Pierce GB (1977) Yolk sac carcinoma (endodermal sinus tumor). Ultrastructure and histogenesis of gonadal and extragonadal tumors in comparison with normal human yolk sac. Cancer 39: 1462

    Google Scholar 

  182. Norgaard-Pedersen B, Albrechtsen R, Teilum G (1975) Serum alpha-fetoprotein as a marker for endodermal sinus tumor (yolk sac tumor), or a vitelline component of teratocarcinoma. Acta Pathol Microbiol Scand (A) 83: 573

    CAS  Google Scholar 

  183. Norris HJ, Jensen RD (1972) Relative frequency of ovarian neoplasms in children and adolescents. Cancer 30: 713

    Article  PubMed  CAS  Google Scholar 

  184. Norris HJ, Zirkin HJ, Benson WL (1976) Immature (malignant) teratoma of the ovary. A clinical and pathologic study of 58 cases. Cancer 37: 2359

    Article  PubMed  CAS  Google Scholar 

  185. Novak E (1952) Gynecologic and obstetric pathology, 3rd ed. Philadelphia, Saunders

    Google Scholar 

  186. Novak E, Gray LA (1938) Dysgerminoma of the ovary. Am J Obstet Gynecol 35: 925

    Google Scholar 

  187. Novak E, Woodruff JD, Novak ER (1954) Probable mesonephric origin of certain female genital tumors. Am J Obstet Gynecol 68: 1224

    Google Scholar 

  188. Novak ER (1948) Solid teratoma of the ovary, with report of five cases. Am J Obstet Gynecol 56: 300

    PubMed  CAS  Google Scholar 

  189. Novak ER, Woodruff JD (1967) In: Novak ER (ed) Gynecologic and obstetric pathology, 6th ed. Philadelphia, Saunders, p 367

    Google Scholar 

  190. Nystrom C (1956) Dysgerminoma of the ovary. Acta Ob-stet Gynecol Scand 35: 385

    Article  CAS  Google Scholar 

  191. Oliver HM, Home EO (1948) Primary teratomatous chorionepithelioma of the ovary. Report of a case. N Engl J Med 239: 14

    Google Scholar 

  192. Overbeck L, Philipp E (1969) Die Ultrastruktur des Disgerminoms im Ovar. Zugleich ein Beitrag zur Histogenese des Tumors. Z Geburtschilfe Gynaekol 170: 125

    Google Scholar 

  193. Palmer PE, Safaii H, Wolfe HJ (1976) Alpha-l-antitrypsin and alpha-fetoprotein markers in endodermal sinus (yolk sac) tumors. Am J Clin Pathol 65: 575

    PubMed  CAS  Google Scholar 

  194. Pantoja E, Noy MA, Axtmayer RW, Colon FE, Pelegrina I (1975) Ovarian dermoids and their complications. Comprehensive historical review. Obstet Gynecol Sury 30: 1

    Google Scholar 

  195. Pantoja E, Rodriguez-Ibanez I, Axtmayer RW, Noy MA, Pelegrina I (1975) Complications of dermoid tumors of the ovary. Obstet Gynecol 45: 89

    PubMed  CAS  Google Scholar 

  196. Park IJ, Pyeatte JC, Jones HW, Woodruff JD (1972) Gonadoblastoma in a true hermaphrodite with 46XY genotype. Obstet Gynecol 40: 466

    PubMed  CAS  Google Scholar 

  197. Patel SK, Prentice SA (1972) Gonadoblastoma-Distinctive ovarian tumor. Arch Pathol 94: 165

    PubMed  CAS  Google Scholar 

  198. Payne D, Muss HB, Homesley HD, Jobson VM, Baird FG (1981) Autoimmune hemolytic anemia and ovarian dermoid cysts. Case report and review of the literature. Cancer 48: 721

    Google Scholar 

  199. Pedowitz P, Felmus LB, Grayzel DM (1955) Dysgerminoma of the ovary. Prognosis and treatment. Am J Obstet Gynecol 70: 1284

    Google Scholar 

  200. Peterson WF (1956) Solid histologically benign teratomas of the ovary. A report of four cases and review of the literature. Am J Obstet Gynecol 72: 1094

    PubMed  CAS  Google Scholar 

  201. Peterson WF (1957) Malignant degeneration of benign cystic teratomas of the ovary: A collective review of the literature. Obstet Gynecol Sury 12: 793

    Article  CAS  Google Scholar 

  202. Peterson WF, Prevost EC, Edmunds FT, Huntley JM Jr., Morris FK (1955) Benign cystic teratomas of the ovary. A clinico-statistical study of 1007 cases with review of the literature. Am J Obstet Gynecol 70: 368

    PubMed  CAS  Google Scholar 

  203. Peyron A (1939) Faits nouveaux relatifs à l’origine et à l’histogenese des embryomes. Bull Assoc Franc Cancer 28: 658

    Google Scholar 

  204. Pierce GB Jr. (1966) Ultrastructure of human testicular tumors. Cancer 19: 1963

    Article  PubMed  Google Scholar 

  205. Pierce, GB Jr., Dixon FJ (1959) Testicular teratomas. 1. Demonstration of teratogenesis by metamorphosis of multipotential cells. Cancer 12: 573

    Google Scholar 

  206. Pierce GB Jr., Dixon FJ (1959) Testicular teratomas. 2. Teratocarcinoma as ascitic tumor. Cancer 12: 584

    Google Scholar 

  207. Pierce GB Jr., Midgley AR (1963) The origin and function of human syncytiotrophoblastic giant cells. Am J Pathol 43: 153

    PubMed  Google Scholar 

  208. Pierce GB Jr., Verney EL (1961) An in vitro and in vivo study of differentiation in teratocarcinomas. Cancer 14: 1017

    Article  PubMed  Google Scholar 

  209. Pierce GB Jr., Bullock WK, Huntington RW Jr. (1970) Yolk sac tumors of the testis. Cancer 25: 644

    Article  PubMed  CAS  Google Scholar 

  210. Pierce GB Jr., Midgley AR, Beals TF (1962) An ultrastructural study of differentiation and maturation of trophoblast of the monkey. Lab Invest 13: 451

    Google Scholar 

  211. Pierce GB Jr., Midgley AR, Sri Ram J, Feldman JD (1964) Parietal yolk sac carcinoma. Clue to the histogenesis of Reichert’s membrane of the mouse embryo. Am J Pathol 41: 549

    Google Scholar 

  212. Plaut A (1933) Ovarian struma: A morphologic, pharmacologic, and biologic examination. Am J Obstet Gynecol 25: 351

    Google Scholar 

  213. Prat J, Bhan AK, Dickersin GR, Robboy SJ, Scully RE (1982) Hepatoid yolk sac tumor of the ovary (endodermal sinus tumor with hepatoid differentiation). A light microscopic ultrastructural and immunohistochemical study of seven cases. Cancer 50: 2355

    Google Scholar 

  214. Qizilbash AH, Trebilcock RG, Patterson MC, Lamont KG (1974) Functioning primary carcinoid tumor of the ovary. A light and electron microscopic study with review of the literature. Am J Clin Pathol 62: 629

    Google Scholar 

  215. Ramsey HJ (1965) Ultrastructure of a pineal tumor. Cancer 18: 1014

    Article  PubMed  CAS  Google Scholar 

  216. Ranchod M, Kempson RL, Dorgeloh JR (1976) Strumal carcinoid of the ovary. Cancer 37: 1913

    Article  PubMed  CAS  Google Scholar 

  217. Rao NR, Veliath GD, Srinivasan M (1964) An unusual case of sacrococcygeal mesonephroma ( Schiller ). Cancer 17: 1604

    Google Scholar 

  218. Rashad MH, Fathalla MF, Kerr MC (1966) Sex chromatin and chromosome analysis in ovarian teratomas. Am J Ob-stet Gynecol 96: 461

    CAS  Google Scholar 

  219. Robboy SJ, Scully RE (1970) Ovarian teratoma with glial implants on the peritoneum. An analysis of 12 cases. Hum Pathol 1: 643

    Article  PubMed  CAS  Google Scholar 

  220. Robboy SJ, Scully RE (1980) Strumal carcinoid of the ovary. An analysis of 50 cases of a distinctive tumor composed of thyroid tissue and carcinoid. Cancer 46: 2019

    Article  PubMed  CAS  Google Scholar 

  221. Robboy SJ, Norris HJ, Scully RE (1975) Insular carcinoid primary in the ovary-A clinicopathologic analysis of 48 cases. Cancer 36: 404

    Article  PubMed  CAS  Google Scholar 

  222. Robboy SJ, Scully RE, Norris HJ (1974) Carcinoid metastatic to the ovary. A clinicopathologic analysis of 35 cases. Cancer 33: 798

    Article  PubMed  CAS  Google Scholar 

  223. Robboy SJ, Scully RE, Norris HJ (1977) Primary trabecular carcinoid of the ovary. Obstet Gynecol 49: 202

    PubMed  CAS  Google Scholar 

  224. Rose LI, Underwood RH, Williams GH, Pincus GS (1974) Pure gonadal dysgenesis. Studies of in vitro androgen metabolism. Am J Med 57: 957

    Google Scholar 

  225. Sailer S (1940) Ovarian dysgerminoma. Am J Cancer 38: 473

    Google Scholar 

  226. Sailer S (1943) Struma ovarii. Am J Clin Pathol 13: 271

    Google Scholar 

  227. Salet J, de Gennes LJ, de Grouchy J, Musset R, Pelissier C, Yaneva H, Sebaoun M, Netter A (1970) A propos d’un cas de gonadoblastome 46XX. Ann Endocrinol (Paris) 31: 927

    CAS  Google Scholar 

  228. Samuels ML, Lanzotti VJ, Holoye PY, Boyle LY, Smith TL, Johnson DE (1976) Combination chemotherapy of germinal cell tumors. Cancer Treat Rev 3: 185

    Article  PubMed  CAS  Google Scholar 

  229. Santesson L (1947) Clinical and pathological survey of ovarian tumours treated at the Radiumhemmet. 1. Dysgerminoma. Acta Radiol (Stockholm) 28: 643

    Google Scholar 

  230. Santesson L, Marrubini G (1957) Clinical and pathological survey of ovarian embryonal carcinomas, including so-called “mesonephreomas” (Schiller) or “mesoblastomas” ( Teilum) treated at the Radiumhemmet. Acta Obstet Gynecol Scand 36: 399

    Google Scholar 

  231. Saunders AM, Hertzman VO (1960) Malignant carcinoid teratoma of the ovary. Can Med Assoc J 83: 602

    PubMed  CAS  Google Scholar 

  232. Schellhas HF (1974) Malignant potential of the dysgenetic gonad. Part 1. Obstet Gynecol 44: 298

    PubMed  CAS  Google Scholar 

  233. Schellhas HF (1974) Malignant potential of the dysgenetic gonad. Part 2. Obstet Gynecol 44: 455

    PubMed  CAS  Google Scholar 

  234. Schellhas HF, Trujillo JM, Rutledge FN, Cork A (1971) Germ cell tumors associated with XY gonadal dysgenesis. Am J Obstet Gynecol 109: 1197

    PubMed  CAS  Google Scholar 

  235. Schiller W (1939) Mesonephroma ovarii. Am J Cancer 35: 1

    Google Scholar 

  236. Schiller W (1942) Histogenesis of ovarian mesonephroma. Arch Pathol 33: 443

    Google Scholar 

  237. Schmitz EF (1925) Malignant endothelioma of perithelioma type in the ovary. Am J Obstet Gynecol 9: 247

    Google Scholar 

  238. Scully RE (1953) Gonadoblastoma. A gonadal tumor related to dysgerminoma (seminoma) and capable of sex hormone production. Cancer 6: 455

    Article  PubMed  CAS  Google Scholar 

  239. Scully RE (1963) Germ cell tumors of the ovary and Fallopian tube. In: Meigs JV, Sturgis SH (eds) Progress in gynecology, Vol 4. New York, Grime and Stratton, pp 335–347

    Google Scholar 

  240. Scully RE (1970) Germ cell tumors of the ovary. In: Sturgis SH, Taymor ML (eds) Progress in gynecology, Vol 5. Grune and Stratton, New York, pp. 329–348

    Google Scholar 

  241. Scully RE (1970) Recent progress in ovarian cancer. Hum Pathol 1: 73

    Article  PubMed  CAS  Google Scholar 

  242. Scully RE (1970) Gonadoblastoma. Cancer 25: 1340

    Article  CAS  Google Scholar 

  243. Scully RE (1970) Sex cord tumor with annular tubules. A distinctive ovarian tumor of the Peutz-Jeghers syndrome. Cancer 25: 1107

    Article  PubMed  CAS  Google Scholar 

  244. Scully RE (1979) Tumors of the ovary and maldeveloped gonads. In: Atlas of tumor pathology, 2nd series, Fasc 16. Washington, D.C., Armed Forces Institute of Pathology

    Google Scholar 

  245. Scully RE (1980) Personal communication

    Google Scholar 

  246. Seegar GE (1938) Ovarian dysgerminomas. Arch Surg 37: 697

    Article  Google Scholar 

  247. Sell A, Sogaard H, Norgaard-Pedersen B (1976) Serum alpha-fetoprotein as a marker for the effects of postoperative radiation therapy and/or chemotherapy in 8 cases of ovarian endodermal sinus tumor. Int J Cancer 18: 574

    Article  PubMed  CAS  Google Scholar 

  248. Sens MA, Levenson TB, Metcalf JS (1982) A case of metastatic carcinoid arising in an ovarian teratoma. Cancer 49: 2541

    Article  PubMed  CAS  Google Scholar 

  249. Senterman MK, Cassidy PN, Fenoglio CM, Ferenczy A (1984) Histology, ultrastructure and immunocytochemistry of strumal carcinoid. A case report. Int J Gynecol Pathol 3: 232

    Google Scholar 

  250. Serov SF, Scully RE, Sobin LH (1973) Histological typing of ovarian tumors. International histological classification of tumors. No 9. Geneva, World Health Organization

    Google Scholar 

  251. Serratoni FT, Robboy SJ (1975) Ultrastructure of primary and metastatic ovarian carcinoids-Analysis of 11 cases. Cancer 36: 157

    Article  PubMed  CAS  Google Scholar 

  252. Shirai T, Itoh T, Yoshiki T, Noro T, Tomino Y, Hayasaka T (1976) Immunofluorescent demonstration of alpha-fetoprotein, and other plasma proteins in yolk sac tumor. Cancer 38: 1661

    Article  PubMed  CAS  Google Scholar 

  253. Sjovall A (1943) Disgerminome des Ovariums. Acta Obstet Gynecol Scand 23: 585

    Article  Google Scholar 

  254. Simard LC (1957) Polyembryonic embryoma of the ovary of parthenogenetic origin. Cancer 10: 215

    Article  PubMed  CAS  Google Scholar 

  255. Smith FG (1946) Pathology and physiology of struma ovarii. Arch Surg 53: 603

    Article  PubMed  CAS  Google Scholar 

  256. Smith JB, O’Neill RT (1971) Alpha-fetoprotein. Occurrence in germinal cell and liver malignancies. Am J Med 51: 767

    Google Scholar 

  257. Smith JP, Rutledge F (1975) Advances in chemotherapy for gynecologic cancer. Cancer 36: 669

    Article  PubMed  CAS  Google Scholar 

  258. Smith JP, Rutledge FN, Sutow WW (1963) Malignant gynecologic tumors in children. Current approaches to treatment. Am J Obstet Gynecol 116: 261

    Google Scholar 

  259. Solomon J, Steinfeld JL, Bateman JR (1967) Chemotherapy of germinal tumors. Cancer 26: 747

    Article  Google Scholar 

  260. Sporrong B, Falkmer S, Robboy SJ, Alumets J, Hakanson R, Ljungberg O, Sundler F (1982) Neurohormonal peptides in ovarian carcinoids. An immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six midgut carcinoids. Cancer 49: 68

    Article  PubMed  CAS  Google Scholar 

  261. Sternberg WH, Barclay DL, Kloepfer HW (1968) Familial XY gonadal dysgenesis. N Engl J Med 278: 695

    Article  PubMed  CAS  Google Scholar 

  262. Stevens LC (1959) Embryology of testicular teratomas in strain 129 mice. J Natl Cancer Inst 23: 1249

    PubMed  CAS  Google Scholar 

  263. Stevens LC (1960) Embryonic potency of embryoid bodies derived from a transplantable testicular teratoma of the mouse. Develop Biol 2: 285

    Article  PubMed  CAS  Google Scholar 

  264. Stevens LC (1962) The biology of teratomas including evidence indicating their origin from primordial germ cells. Ann Biol 1: 585

    CAS  Google Scholar 

  265. Strauss AF, Gates HS (1964) Giant sebaceous gland tumor of the ovary. Am J Clin Pathol 41: 78

    PubMed  CAS  Google Scholar 

  266. Subbuswamy SG, Gibbs NM, Ross CF, Morson BC (1974) Goblet cell carcinoid of the appendix. Cancer 34: 338

    Article  PubMed  CAS  Google Scholar 

  267. Szokol M, Kondrai G, Papp, Z (1977) Gonadal malignancy and 46XY karyotype in a true hermaphrodite. Obstet Gynecol 49: 358

    PubMed  CAS  Google Scholar 

  268. Takeda A, Ishizuka T, Goto T, Goto S, Ohta M, Tomoda Y, Hoshino M (1982) Polyembryoma of ovary producing alpha-fetoprotein and HCG. Immunoperoxidase and electron microscopic study. Cancer 49: 1878

    Google Scholar 

  269. Talerman A (1971) Gonadoblastoma and dysgerminoma in two siblings with dysgenetic gonads. Obstet Gynecol 38: 416

    PubMed  CAS  Google Scholar 

  270. Talerman A (1972) A distinctive gonadal neoplasm related to gonadoblastoma. Cancer 30: 1219

    Article  PubMed  CAS  Google Scholar 

  271. Talerman A (1972) A mixed germ cell-sex cord stroma tumor in a normal female infant. Obstet Gynecol 40: 473

    PubMed  CAS  Google Scholar 

  272. Talerman A (1974) Gonadoblastoma associated with embryonal carcinoma. Obstet Gynecol 43: 138

    PubMed  CAS  Google Scholar 

  273. Talerman A (1975) The incidence of yolk sac tumor (endodermal sinus tumor) elements in germ cell tumors of the testis in adults. Cancer 36: 211

    Article  PubMed  CAS  Google Scholar 

  274. Talerman A (1980) The pathology of gonadal neoplasms composed of germ cells and sex cord stroma derivatives. Pathol Res Pract 170: 24

    Article  PubMed  CAS  Google Scholar 

  275. Talerman A (1984) Carcinoid tumors of the ovary. J Cancer Res Clin Oncol 107: 125

    Article  PubMed  CAS  Google Scholar 

  276. Talerman A, Delemarre JFM (1975) Gonadoblastoma associated with embryonal carcinoma in an anatomically normal male. J Urol 113: 355

    PubMed  CAS  Google Scholar 

  277. Talerman A, Evans MI (1982) Primary trabecular carcinoid tumor of the ovary. Cancer 50: 1407

    Article  Google Scholar 

  278. Talerman A, Haije WG (1974) Alpha-fetoprotein and germ cell tumors. A possible role of yolk sac tumor in production of alpha-fetoprotein. Cancer 34: 1722

    Google Scholar 

  279. Talerman A, Haije WG (1985) Ovarian Sertoli cell tumor with retiform and heterologous elements. Am J Surg Pathol 9: 459

    Article  PubMed  CAS  Google Scholar 

  280. Talerman A, Okagaki T (1985) Ultrastructural features of primary trabecular carcinoid tumor of the ovary. Int J Gynecol Pathol 4: 153

    Article  PubMed  CAS  Google Scholar 

  281. Talerman A, Okagaki T (unpublished observations)

    Google Scholar 

  282. Talerman A, van der Harten JJ (1977) A mixed germ cell-sex cord stroma tumor of the ovary associated with isosexual precocious puberty in a normal female child. Cancer 40: 889

    Article  PubMed  CAS  Google Scholar 

  283. Talerman A, Haije WG, Baggerman L (1977) Alpha-1antitrypsin (AAT) and alpha-foetoprotein (AFP) in sera of patients with germ cell neoplasms. Value as tumor markers in patients with endodermal sinus tumour (yolk sac tumour). Int J Cancer 19: 741

    Google Scholar 

  284. Talerman A, Haije WG, Baggerman L (1978) Histological patterns in germ cell neoplasms associated with raised serum alphafoetoprotein (AFP). Scand J Immunol 8 [Suppl]: 97

    Article  Google Scholar 

  285. Talerman A, Haije WG, Baggerman L (1978) Serum alphafetoprotein in diagnosis and management of endodermal sinus (yolk sac) tumor and mixed germ cell tumor of the ovary. Cancer 41: 272

    Article  PubMed  CAS  Google Scholar 

  286. Talerman A, Haije WG, Baggerman L (1980) Serum alphafetoprotein (AFP) in patients with germ cell tumors of the gonads and extragonadal sites. Correlation between endodermal sinus (yolk sac) tumor and raised serum AFP. Cancer 46: 340

    Google Scholar 

  287. Talerman A, Huyzinga WT, Kuipers T (1973) Dysgerminoma. Clinicopathologic study of 22 cases. Obstet Gynecol 41: 137

    PubMed  CAS  Google Scholar 

  288. Talerman A, Jarabak J, Amarose A (1981) Gonadoblastoma and dysgerminoma in a true hermaphrodite with 46,XX karyotype. Am J Obstet Gynecol 140: 175

    Google Scholar 

  289. Talerman A, van der Pompe WB, Haije WG, Baggerman L, Boekestein-Tjahjadi HM (1977) Alpha-fetoprotein and carcinoembryonic antigen in germ cell neoplasms. Br J Cancer 35: 288

    Article  PubMed  CAS  Google Scholar 

  290. Taylor CW (1972) Müllerian mixed tumor. Acta Pathol Microbiol Scand [80A Suppl] 233: 48

    Google Scholar 

  291. Taylor MH, Depetrillo AD, Turner AR (1985) Vinblastine, bleomycin, and cisplatin in malignant germ cell tumors of the ovary. Cancer 56: 1341

    Article  PubMed  CAS  Google Scholar 

  292. Teilmann I, Kassis H, Pietra G (1967) Primary germ cell tumour of the anterior mediastium with features of endodermal sinus tumour (mesoblastoma vitellinum). Acta Pathol Microbiol Scand 70: 267

    Article  PubMed  CAS  Google Scholar 

  293. Teilum G (1944) Homologous tumours in ovary and testis: Contribution to classification of gonadal tumours. Acta Obstet Gynecol Scand 24: 480

    Article  Google Scholar 

  294. Teilum G (1946) Gonocytoma; homologous ovarian and testicular tumours. 1. With discussion of “mesonephroma ovarii” (Schiller: Am J Cancer 1939). Acta Pathol Microbiol Scand 23: 242

    Article  Google Scholar 

  295. Teilum G (1950) “mesonephroma ovarii” (Schiller) extra-embryonic mesoblastoma of germ cell origin in ovary and testis. Acta Pathol Microbiol Scand 27: 249

    Google Scholar 

  296. Teilum G (1952) Classification of ovarian tumours. Acta Obstet Gynecol Scand 31: 292

    Article  PubMed  CAS  Google Scholar 

  297. Teilum G (1959) Endodermal sinus tumors of the ovary and testis. Comparative morphogenesis of the so-called mesonephroma ovarii (Schiller) and extraembryonic (yolk sac-allantoic) structures of the rat’s placenta. Cancer 12: 1092

    Google Scholar 

  298. Teilum G (1965) Classification of endodermal sinus tumour (mesoblastoma vitellinum) and so-called embryonal carcinoma of the ovary. Acta Pathol Microbiol Scand 64: 407

    PubMed  CAS  Google Scholar 

  299. Teilum G (1968) Tumours of germinal origin. In: Gentil F, Junqueira AC (eds) Ovarian cancer, U.I. C. C. Monograph Series, Vol 11. Berlin, Heidelberg, New York, Springer-Verlag, pp 58–73

    Chapter  Google Scholar 

  300. Teilum G (1976) Special tumors of the ovary and testis. Comparative histology and identification, 2nd ed. Copenhagen, Munksgaard

    Google Scholar 

  301. Teilum G, Albrechtsen R, Norgaard-Pedersen B (1974) Immunofluorescent localization of alpha-fetoprotein synthesis in endodermal sinus tumor (yolk sac tumor). Acta Pathol Microbiol Scand 82A: 586

    CAS  Google Scholar 

  302. Teilum G, Albrechtsen R, Norgaard-Pedersen B (1975) The histogenetic-embryologic basis for reappearance of alpha-fetoprotein in endodermal sinus tumors and teratomas. Acta Pathol Microbiol Scand 83A: 80

    CAS  Google Scholar 

  303. Teter J (1960) A new concept of classification of gonadal tumors arising from germ cell (gonocytoma) and their histogenesis. Gynaecologia (Basel) 150: 84

    CAS  Google Scholar 

  304. Teter J (1962) A mixed form of feminizing germ cell tumor (gonocytoma II). Am J Obstet Gynecol 84: 722

    PubMed  CAS  Google Scholar 

  305. Teter J (1970) Prognosis, malignancy and curability of the germ cell tumor occurring in dysgenetic gonads. Am J Obstet Gynecol 108: 894

    PubMed  CAS  Google Scholar 

  306. Teter J, Boczkowski K (1967) Occurrence of tumors in dysgenetic gonads. Cancer 20: 1301

    Article  PubMed  CAS  Google Scholar 

  307. Theiss EA, Ashley DJB, Mostofi FK (1959) Nuclear sex of testicular tumors and some related ovarian and extragonadal neoplasms. Cancer 13: 323

    Article  Google Scholar 

  308. Thoeny RH, Dockerty MB, Hunt AB, Childs DS Jr. (1961) Study of ovarian dysgerminoma with emphasis on the role of radiation therapy. Surg Gynecol Obstet 113: 692

    PubMed  CAS  Google Scholar 

  309. Thurlbeck WM, Scully RE (1960) Solid teratoma of the ovary. Cancer 13: 804

    Article  PubMed  CAS  Google Scholar 

  310. Toker C (1969) Ovarian carcinoid. A light and electron microscopic study. Am J Obstet Gynecol 103: 1019

    Google Scholar 

  311. Tsuchida Y, Kaneko M, Yokomori K, Saito S, Urano Y, Endo Y, Asaka T, Takeuchi T (1978) Alpha-fetoprotein, prealbumin, albumin, alpha-1-antitrypsin, and transferrin as diagnostic and therapeutic markers for endodermal sinus tumors. J Pediatr Surg 13: 25

    Article  PubMed  CAS  Google Scholar 

  312. Turner HB, Douglas WM, Cladding TC (1964) Choriocarcinoma of the ovary. Obstet Gynecol 24: 918

    PubMed  CAS  Google Scholar 

  313. Ueda G, Sato Y, Yamasaki M, Inoue M, Hiramatsu J, Kurachi K, Amino N, Miyai K (1978) Strumal carcinoid of the ovary. Histological, ultrastructural, and immunohistological studies with anti-human thyroglobulin. Gynecol Oncol 6: 411

    Google Scholar 

  314. Ulbright TM, Roth LM, Erlich CE (1982) Ovarian strumal carcinoid. An immunocytochemical and ultrastructural study of two cases. Am J Clin Pathol 77: 622

    Google Scholar 

  315. Uzisima H (1956) Ovarian dysgerminoma associated with virilization. Report of a case. Cancer 9: 736

    Article  Google Scholar 

  316. Vance RP, Geisinger KR (1985) Pure nongestational choriocarcinoma of the ovary. Report of a case. Cancer 56: 2321

    Google Scholar 

  317. Vawter GF (1965) Carcinoma of the vagina in infancy. Cancer 18: 1479

    Article  PubMed  CAS  Google Scholar 

  318. Warkel RL, Cooper PH, Helwig EB (1978) Adenocarcinoid, a mucin-producing carcinoid of the appendix. Cancer 42: 2781

    Article  PubMed  CAS  Google Scholar 

  319. Weldon-Linne CM, Rushovich AM (1983) Benign ovarian cystic teratomas with homunculi. Obstet Gynecol 61: 88S

    Google Scholar 

  320. Wheatley VR (1957) Further observations on the nature of the dermoid cyst fat. J Invest Dermatol 29: 445

    PubMed  CAS  Google Scholar 

  321. Whelton JA, Fallôn RJ (1964) Successful pregnancy after surgery and supervoltage therapy for metastatic dysgerminoma. N Engl J Med 271: 145

    Article  PubMed  CAS  Google Scholar 

  322. Wider JA, O’Leary JA (1968) Dysgerminoma: A clinical review. Obstet Gynecol 31: 560

    Google Scholar 

  323. Wider JA, Marshall JR, Bardin CW, Lipsett MB, Rose GT (1969) Sustained remissions after chemotherapy for primary ovarian cancers containing choriocarcinoma. N Engl J Med 280: 1439

    Article  PubMed  CAS  Google Scholar 

  324. Wieland RG, Ekstrom B, Vorijs N (1968) C19O2 Steroid secretion by dysgenetic gonads. Obstet Gynecol 32: 643

    PubMed  CAS  Google Scholar 

  325. Wilkinson EJ, Friedrich EG, Hosty TA (1973) Alpha-fetoprotein and endodermal sinus tumor of the ovary. Am J Obstet Gynecol 116: 711

    PubMed  CAS  Google Scholar 

  326. Williams ED (1966) Histogenesis of medullary carcinoma of the thyroid. J Clin Pathol 19: 114

    Article  PubMed  CAS  Google Scholar 

  327. Williams ED, Sandler M (1963) Classification of carcinoid by embryologic grouping. Lancet 1: 238

    Article  PubMed  CAS  Google Scholar 

  328. Williamson HO, Underwood PB Jr, Kreutner A Jr, Rogers JF, Mathur RS, Pratt-Thomas HR (1976) Gonadoblastoma: Clinicopathologic correlation in six patients. Am J Obstet Gynecol 126: 579

    Google Scholar 

  329. Willis RA (1958) The borderland of embryology and pathology. London, Butterworth

    Google Scholar 

  330. Willis RA (1967) Pathology of tumours, 4th ed. London, Butterworth

    Google Scholar 

  331. Wisniewski M, Deppisch LM (1973) Solid teratomas of the ovary. Cancer 32: 440

    Article  PubMed  CAS  Google Scholar 

  332. Witschi E (1948) Migration of the germ cells of human embryos from the yolk sac to the primitive gonadal folds. Contrib Embryol 32: 69

    Google Scholar 

  333. Woodruff JD, Markley RL (1957) Struma ovarii. Demon-stration of both pathologic change and physiologic activity; report of four cases. Obstet Gynecol 9: 707

    Google Scholar 

  334. Woodruff JD, Protos P, Peterson WF (1968) Ovarian teratomas. Relationship of histologic and ontogenic factors to prognosis. Am J Obstet Gynecol 102: 702

    Google Scholar 

  335. Woodruff JD, Rauh JT, Markley RL (1966) Ovarian struma. Obstet Gynecol 27: 194

    CAS  Google Scholar 

  336. Wurster K, Hedinger C, Meienberg 0 (1972) Orchioblastomatous foci in testicular teratoma of adults. Virchow’s Arch [Pathol Anat] 357: 231

    Article  CAS  Google Scholar 

  337. Young RH, Scully RE (1983) Ovarian Sertoli-Leydig cell tumors with a retiform pattern. A problem in histopathologic diagnosis. A report of 25 cases. Am J Surg Pathol 7: 755

    PubMed  CAS  Google Scholar 

  338. Young RH, Perez-Atayde AR, Scully RE (1984) Ovarian Sertoli-Leydig cell tumor with retiform and heterologous elements. Report of a case with hepatocytic differentiation and elevated serum alpha-fetoprotein. Am J Surg Pathol 8: 709

    Google Scholar 

  339. Young RH, Prat J, Scully RE (1982) Ovarian Sertoli-Leydig cell tumors with heterologous elements (1) gastrointestinal epithelium and carcinoid: A clinicopathologic analysis of thirty six cases. Cancer 50: 2448

    Google Scholar 

  340. Zaloudek C, Tavassoli FA, Norris HJ (1981) Dysgerminoma with syncytiotrophoblastic giant cells. A histologically and clinically distinctive subtype of dysgerminoma. Am J Surg Pathol 5: 361

    Google Scholar 

  341. Zondag HA (1964) Enzyme activity in dysgerminoma and seminoma. A study of lactic dehydrogenase isoenzymes in malignant diseases. Rhode Island Med J 47: 273

    PubMed  CAS  Google Scholar 

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Authors
  1. A. Talerman M.D.,Ph.D.
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  2. F. R. C. Path
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Editors and Affiliations

  1. Departments of Pathology and Obstetrics and Gynecology, Georgetown University School of Medicine, 20007, Washington, DC, USA

    Robert J. Kurman M.D. (Professor of Pathology and Obstetrics and Gynecology, Director) (Professor of Pathology and Obstetrics and Gynecology, Director)

  2. Gynecologic Pathology, Georgetown University Hospital, Washington, D.C., USA

    Robert J. Kurman M.D. (Professor of Pathology and Obstetrics and Gynecology, Director) (Professor of Pathology and Obstetrics and Gynecology, Director)

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Talerman, A., Path, F.R.C. (1987). Germ Cell Tumors of the Ovary. In: Kurman, R.J. (eds) Blaustein’s Pathology of the Female Genital Tract. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-1942-0_20

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  • DOI: https://doi.org/10.1007/978-1-4757-1942-0_20

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