Summary
The orchioblastoma or clear cell adenocarcinoma is considered to be a typical tumor of the infant testis. In a collection of 122 testicular teratomas in adults, using Collins and Pugh's classification, 37% of the tumors are found with different large foci of orchioblastoma-like tissue. 7.4% of these tumors contain extensive orchioblastoma-like structures or consist almost entirely of them. These structures can also be found in metastases of teratomas independently, whether or not they exist in primary tumors. While orchioblastoma-like tissue is found relatively often in malignant teratomas intermediate type A and B, they are missing in the groups of teratomas differentiated and teratomas anaplastic, corresponding to the definition of these groups. There are no essential differences in the clinical course of teratomas, with or without orchioblastoma-like structures. The relationship of the so-called orchioblastoma to orchioblastoma-like tissue in teratomas, and therefore to the teratomas themselves, is discussed.
Zusammenfassung
Das Orchioblastom oder hellzellige Adenocarcinom gilt als typische Geschwulst des kindlichen Hodens. In einer Sammlung von 122 Hodenteratomen des Erwachsenen, klassiert nach der Einteilung von Collins und Pugh, finden sich in 37% der Tumoren unterschiedlich große Herde aus orchioblastomartig gebautem Gewebe. 7,4% dieser Tumoren enthalten sogar sehr ausgedehnte derartige Anteile oder bestehen fast vollständig daraus. Auch in Teratommetastasen können orchioblastomartige Herde nachgewiesen werden, unabhängig davon, ob sie in den Primärtumoren vorhanden sind oder nicht. Während orchioblastomartige Gewebe in den Intermediärtypen A und B der malignen Teratome relativ häufig vorkommen, fehlen sie definitionsgemäß in den Gruppen der differenzierten Teratome und der anaplastischen Teratome. Wesentliche Unterschiede im klinischen Verlauf von Teratomen mit orchioblastomartigen Herden und solchen ohne orchioblastomartige Herde bestehen nicht. Die Beziehung des Orchioblastoms zu den orchioblastomartigen Herden in den Teratomen und damit zu den Teratomen überhaupt wird diskutiert.
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Literatur
Abell, M. R., Holtz, F.: Testicular neoplasms in infants and children. Cancer (Philad.) 16, 965–971 (1963).
Agarwal, S., Chouhan, S. S., Pratap, V. K.: Orchioblastoma (Adenocarcinoma of the infant testis). Indian J. Cancer 4, 247–253 (1967).
Basu Mallik, K. C.: A rare tumor of the testis in infants. A report of two cases. J. Indian med. Ass. 38, 131–132 (1962).
Collins, D. H., Pugh, R. C. B.: The pathology of testicular tumors. Brit. J. Urol., Suppl. XXXVI, No. 2 (1964).
Dixon, F. J., Moore, R. A.: Tumors of the male sex organs. Atlas of tumor pathology, sect. 8, fasc. 31b and 32. Washington, D. C.: Armed Forces Institute of Pathology 1952.
Dixon, F. J., Moore, R. A.: Testicular tumors—A clinicopathological study. Cancer (Philad.) 6, 427–454 (1953).
Dutta, L. P., Mahanta, J.: Orchioblastoma. J. Indian med. Ass. 51, 354–355 (1968).
Duval, M.: Le placenta des rongeurs. J. anat. et physiol. 27, 24–73, 344–395, 515–612, pl. 1–4, 15–18, 23–25 (1891).
Huntington, R. W., Morgenstern, N. L., Sargent, J. A., Giem, R. N., Richards, A., Hanford, K. C.: Germinal tumors exhibiting the endodermal sinus pattern of Teilum in young children. Cancer (Philad.) 16, 34–47 (1963).
Karly, M.: Orchioblastome ou adénocarcinome à cellules claires du testicule chez l'enfant. Helv. paediat. Acta 23, 403–418 (1968).
Kleinsmith, L. J., Pierce, G. B.: Multipotentiality of single embryonal carcinoma cells. Cancer Res. 24, 1544–1551 (1964).
Magner, D., Campbell, J. S., Wiglesworth, F. W.: Testicular adenocarcinoma with clear cells, occurring in infancy. Cancer (Philad.) 9, 165–175 (1956).
Magner, D., Campbell, J. S., Wiglesworth, F. W.: Adenocarcinoma with clear cells occurring in infancy: A distinctive tumour. Canad. med. Ass. J. 86, 485–488 (1962).
Melicow, M. M.: Classification of tumors of testis: A clinical and pathological study based on 105 primary and 13 secondary cases in children. J. Urol. (Baltimore) 73, 547–574 (1955).
Mostofi, F. K.: Infantile testicular tumors. Bull. N. Y. Acad. Med. 28, 684–687 (1952).
Mostofi, F. K.: Persönliche Mitteilung.
Pierce, G. B., Beal, T. F.: The ultrastructure of primordial germinal cells of the fetal testes and of embryonal carcinoma cells of mice. Cancer Res. 24, 1553–1568 (1964).
Pierce, G. B., Bullock, W. K., Huntington, R. W.: Yolk sac tumors of the testis. Cancer (Philad.) 25, 644–658 (1970).
Pierce, G. B., Dixon, F. J.: Testicular teratomas. I. Demonstration of teratogenesis by metamorphosis of multipotential cells. Cancer (Philad.) 12, 573–583 (1959).
Pierce, G. B., Dixon, F. J.: Testicular teratomas. II. Teratocarcinoma as an ascitic tumor. Cancer (Philad.) 12, 584–589 (1959).
Pierce, G. B., Dixon, F. J., Verney, E. L.: Teratocarcinogenic and tissue-forming potentials of the cell types comprising neoplastic embryoid bodies. Lab. Invest. 9, 583–602 (1960).
Pierce, G. B., Midgley, A. R., Sri Ram, J., Feldman, J. D.: Parietal yolk sac carcinoma: Clue to the histogenesis of Reichert's membrane of the mouse embryo. Amer. J. Path. 41, 549–557 (1962).
Pierce, G. B., Stevens, L. C., Nakane, P. K.: Ultrastructural analysis of the early development of teratocarinomas. J. nat. Cancer Inst. 39, 755–761 (1967).
Pierce, G. B., Verney, E. L.: An in vitro and in vivo study of differentiation in teratocarcinomas. Cancer (Philad.) 14, 1017–1029 (1961).
Pratap, V. K., Agarwal, S.: Testicular tumors in children. Indian J. Cancer 6, 76–81 (1969).
Ravich, L., Lerman, P. H., Drabkin, J. W., Noya, J.: Embryonal carcinoma of testicle in childhood: Review of literature and presentation of 2 cases. J. Urol. (Baltimore) 96, 501–507 (1966).
Schiller, W.: Mesonephroma ovarii. Amer. J. Cancer 35, 1–21 (1939).
Teilum, G.: “Mesonephroma ovarii” (Schiller), extra-embryonic mesoblastoma of germ cell origin in ovary and testis. Acta path. microbiol. scand. 27, 249–261 (1950).
Teilum, G.: Endodermal sinus tumors of the ovary and testis. Comparative morphogenesis of the so-called mesonephroma ovarii (Schiller) and extraembryonic (yolk sac-allantoic) structures of the rat's placenta. Cancer (Philad.) 12, 1092–1105 (1959).
Teilum, G.: Classification of endodermal sinus tumor (mesoblastoma vitellinum) and so-called “embryonal carcinoma” of the ovary. Acta path. microbiol. scand. 64, 407–429 (1965).
Teilum, G.: Special tumors of ovary and testis. Comparative pathology and histological identification, p. 33–74, Copenhagen: Munksgaard 1971.
Teoh, T. B., Steward, J. K., Willis, R. A.: The distinctive adenocarcinoma of the infant's testis: An account of 15 cases. J. Path. Bact. 80, 147–156 (1960).
Weitzner, S.: Adenocarcinoma of infantile testis. Amer. J. Dis. Child. 108, 662–666 (1964).
Willnow, U., Hofmann, V., Gläser, A.: Hodentumoren im Säuglings- und Kindesalter. Klinische und morphologische Untersuchungen. Helv. chir. Acta 37, 337–355 (1970).
Young, P. G., Mount, B. M., Foote, F. W., Whitmore, W. F.: Embryonal adenocarcinoma in the prepubertal testis. A clinicopathologic study of 18 cases. Cancer (Philad.) 26, 1065–1075 (1970).
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Wurster, K., Hedinger, C. & Meienberg, O. Orchioblastomartige Herde in Hodenteratomen von Erwachsenen. Virchows Arch. Abt. A Path. Anat. 357, 231–242 (1972). https://doi.org/10.1007/BF00542850
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DOI: https://doi.org/10.1007/BF00542850