Abstract
In this piece I present some of the biological issues and technical approaches that led to the cloning and functional identification of the first lysophosphlipid receptor gene, named “ventricular zone gene-1” or “vzg-1” that serves as a receptor for lysophosphatidic acid (LPA). Based on its prominent expression in the mammalian central nervous system (CNS), it is likely that this and related receptor-ligand interactions represent a novel signaling system for brain development and function. Moreover, this identity has provided a rationale for examining the same and/or structurally similar ligands on homologous orphan receptors either published or in the databases, and indicates that lysophosphlipid receptors form a distinct subfamily of the G-protein coupled receptor (GPCR) superfamily.
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Chun, J. (1999). The First Cloned and Identified Lysophospholipid (LP) Receptor Gene, VZG-1: Implications for Related Receptors and the Nervous System. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E.A. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. Advances in Experimental Medicine and Biology, vol 469. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4793-8_52
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DOI: https://doi.org/10.1007/978-1-4615-4793-8_52
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