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Homeodomain Proteins in Pancreas Development

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Molecular Basis of Pancreas Development and Function

Part of the book series: Endocrine Updates ((ENDO,volume 11))

Abstract

The pancreas derives from the upper, duodenal part of the foregut via a dorsal and ventral protrusion of the epithelium directly posterior to the developing stomach, and in the mouse, the early pancreatic buds become evident on embryonic day 9 (e9) (Figure 1). The part of the gut from which the pancreas originates becomes committed to a pancreatic fate already at the ∼10 somites stage, i.e. at e8.5 (1). A few somites later these regions of the duodenal epithelium will begin to evaginate, thus forming the dorsal and ventral pancreatic buds. During embryogenesis the pancreatic epithelium proliferates and invades the surrounding mesenchyme and the epithelial cells differentiate and segregate into duct, acinar and endocrine cells. As the stomach and duodenum rotates, the ventral bud will move around until it eventually comes in contact and fuses with its dorsal counterpart around e13-14 (Figure 1).

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Authors and Affiliations

  1. University of Umeå, S-90187, Umeå, Sweden

    Ulf Ahlgren Ph.D. & Helena Edlund Ph.D.

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  1. Ulf Ahlgren Ph.D.
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  2. Helena Edlund Ph.D.
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Editors and Affiliations

  1. Laboratory of Molecular Endocrinology, Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA

    Joel F. Habener M.D.

  2. Department of Medicine, Clinical and Molecular Endocrinology, New York University Medical Center, New York, NY

    Mehboob A. Hussain M.D.

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Ahlgren, U., Edlund, H. (2001). Homeodomain Proteins in Pancreas Development. In: Habener, J.F., Hussain, M.A. (eds) Molecular Basis of Pancreas Development and Function. Endocrine Updates, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1669-9_11

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