Abstract
The striking structural and anatomical parallels between the vasculature and the nervous system is reflected by the fact that these two organ systems appear to use related mechanisms during their development. Thus, it is not surprising that an increasing number of vascular biologists and researchers in the neuroscience field are fascinated by molecules that play an important role in both systems.
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REFERENCES
Shima DT, Mailhos C. Vascular developmental biology: Getting nervous. Curr Opin Genet Dev 2000; 10:536–542.
Clauss M. Molecular biology of the VEGF and the VEGF receptor family. Semin Thromb Hemost 2000; 26:561–569.
Breier G. Functions of the VEGF/VEGF receptor system in the vascular system. Semin Thromb Hemost 2000; 26:553–559.
Tamagnone L, Comoglio PM. Signalling by semaphorin receptors: Cell guidance and beyond. Trends Cell Biol 2000; 10:377–383.
Robinson CJ, Stringer SE. The splice variants of vascular endothelial growth factor (VEGF) and their receptors. J Cell Sci 2001; 114:853–865.
Maglione D, Guerriero V, Viglietto G et al. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc Natl Acad Sci USA 1991; 88:9267–9271.
Park JE, Chen HH, Winer J et al. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-i/KDR. J Biol Chem 1994; 269:25646–25654.
Hatva E, Kaipainen A, Mentula P et al. Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors. Am J Pathol 1995; 146:368–378.
Nomura M, Yamagishi S, Harada S et al. Placenta growth factor (PIGF) mRNA expression in brain tumors. J Neuro-Oncol 1998; 40:123–130.
Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997; 18:4–25.
Clauss M. Functions of the VEGF receptor-1 (Flt-1) in the vasculature. Trends Cardiovasc Med 1998; 8:241–245.
Carmeliet P, Moons L, Luttun A et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nature Med 2001; 7:575–583.
Olofsson B, Pajusola K, Kaipainen A et al. Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proc Natl Acad Sci USA 1996; 93:2576–2581.
Olofsson B, Korpelainen E, Pepper MS et al. Vascular endothelial growth-factor B (VEGFB) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc Natl Acad Sci USA 1998; 95:11709–11714.
Lagercrantz J, Farnebo F, Larsson C et al. A comparative study of the expression patterns for vegf vegf-b/vrf and vegf-c in the developing and adult mouse. BiochimBiophys Acta 1998; 1398:157–163.
Joukov V, Pajusola K, Kaipainen A et al. A novel vascular endothelial growth factor, VEGFC, is a ligand for the flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J 1996; 15:290–298.
Joukov V, Sorsa T, Kumar V et al. Proteolytic processing regulates receptor specificity and activity of VEGF-C. EMBO J 1997; 16:3898–3911.
Lee J, Gray A, Yuan J et al. Vascular endothelial growth factor-related protein: A ligand and specific activator of the tyrosine kinase receptor Flt4. Proc Natl Acad Sci USA 1996; 93:1988–1992.
Jeltsch M, Kaipainen A, Joukov V et al. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science 1997; 276:1423–1425.
Witzenbichler B, Asahara T, Murohara T et al. Vascular endothelial growth factor-C (VEGFC/VEGF-2) promotes angiogenesis in the setting of tissue ischemia. Am J Pathol 1998; 153:381–394.
Enholm B, Jussila L, Karkkainen M et al. Vascular endothelial growth factor-C: A growth factor for lymphatic and blood vascular endothelial cells. Trends Cardiovasc Med 1998; 8:292–297.
Cao Y, Linden P, Farnebo J et al. Vascular endothelial growth factor C induces angiogenesis in vivo. Proc Natl. Acad Sci USA 1998; 95:14389–14394.
Dumont DJ, Jussila L, Taipale J et al. Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 1998; 282:946–949.
Achen MG, Jeltsch M, Kukk E et al. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (F1t4). Proc Natl Acad Sci USA 1998; 95:548–553.
Yamada Y, Nezu J, Shimane M et al. Molecular cloning of a novel vascular endothelial growth factor, VEGF-D. Genomics 1997; 42:483–488.
Lyttle DJ, Fraser KM, Fleming SB et al. Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus. J Virol 1994; 68:84–92.
Ogawa S, Oku A, Sawano A et al. A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain. J Biol Chem 1998; 273:31273–31282.
Meyer M, Clauss M, Lepple-Wienhues A et al. A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases. EMBO J 1999; 18:363–374.
Wise LM, Veikkola T, Mercer AA et al. Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1. Proc Natl Acad Sci USA 1999; 96:3071–3076.
Ogunshola 00, Stewart WB, Mihalcik V et al. Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain. Develop Brain Res 2000; 119:139–153.
Neufeld G, Cohen T, Gengrinov itch S et al. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999; 13:9–22.
Senger DR, Galli SJ, Dvorak AM et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983; 219:983–985.
Keck PJ, Hauser SD, Krivi G et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 1989; 246:1309–1312.
Marti HH, Risau W. Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors. Proc Natl Acad Sci USA 1998; 95:15809–15814.
Carmeliet P, Ferreira V, Breier G et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380:435–439.
Ferrara N, Carver-Moore K, Chen H et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996; 380:439–442.
Soker S, Takashima S, Miao HQ et al. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998; 92:735–745.
Gluzman-Poltorak Z, Cohen T, Herzog Y et al. Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165. J Biol Chem 2000; 275:18040–18045.
Fong G-H, Rossant J, Gertsenstein M et al. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995; 376:66–70.
Shalaby F, Rossant J, Yamaguchi TP et al. Failure of blood-island formation and vasculogenesis in flk-l-deficient mice. Nature 1995; 376:62–66.
Kawasaki T, Kitsukawa T, Bekku Y et al. A requirement for neuropilin-1 in embryonic vessel formation. Development 1999; 126:4895–4902.
Breier G, Albrecht U, Sterrer S et al. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 1992; 114:521–532.
Marti HH, Risau W. Angiogenesis in ischemic disease. Thromb Haemost 1999; 82 (Suppl.):44–52.
Ryuto M, Ono M, Izumi H et al. Induction of vascular endothelial growth factor by tumor necrosis factor a in human glioma cells. Possible roles of SP-1. J Biol Chem 1996; 271:28220–28228.
Stavri GT, Zachary IC, Baskerville PA et al. Basic fibroblast growth factor upregulates the expression of vascular endothelial growth factor in vascular smooth muscle cells. Synergistic action with hypoxia. Circulation 1995; 92:11–14.
Shweiki D, Neeman M, Itin A et al. Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: Implications for tumor angiogenesis. Proc Natl Acad Sci USA 1995; 92:768–772.
Shweiki D, Itin A, Soffer D et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359:843–845.
Plate KH, Breier G, Weich HA et al. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992; 359:845–848.
Forsythe JA, Jiang B-H, lyer NV et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996; 16:4604–4613.
Ema M, Taya S, Yokotani N et al. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor la regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 1997; 94:4273–4278.
Ikeda E, Achen MG, Breier G et al. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor (VEGF) in C6 glioma cells. J Biol Chem 1995; 270:19761–19766.
Stein I, Itin A, Einat P et al. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: Implications for translation under hypoxia. Mol Cell Biol 1998; 18:3112–3119.
Wenger RH. Mammalian oxygen sensing, signalling and gene regulation. J Exp Biol 2000; 203:1253–1263.
Semenza GL. HIF-1 and human disease: One highly involved factor. Genes Dev 2000; 14:1983–1991.
Tian H, McKnight SL, Russell DW. Endothelial pas domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1997; 11:72–82.
Flamme I, Fr hlich T, von Reutem M et al. HRF, a putative basic helix-loop-helix-PASdomain transcription factor is closely related to hypoxia-inducible factor-la and developmentally expressed in blood vessels. Mech Develop 1997; 63:51–60.
Hogenesch JB, Chan WK, Jackiw VII et al. Characterization of a subset of the basic-helixloop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem 1997; 272:8581–8593.
Maltepe E, Keith B, Arsham AM et al. The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia. Biochem Biophys Res Commun 2000; 273:231–238.
Wenger RH, Rolfs A, Marti HH et al. Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-la. Biochem Biophys Res Commun 1996; 223:54–59.
Wenger RH, Kvietikova I, Rolfs A et al. Hypoxia-inducible factor-la is regulated at the post-mRNA level. Kidney Int 1997; 51:560–563.
Maxwell PH, Wiesener MS, Chang GW et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999; 399:271–275.
Ivan M, Kondo K, Yang HF et al. HIFa targeted for VHL-mediated destruction by proline hydroxylation: Implications for 02 sensing. Science 2001; 292:464–468.
Jaakkola P, Mole DR, Tian YM et al. Targeting of HIF a to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001; 292:468–472.
Talks KL, Turley H, Gatter KC et al. The expression and distribution of the hypoxia-inducible factors HIF-la and HIF-2a in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000; 157:411–421.
Chavez JC, Agani F, Pichiule P et al. Expression of hypoxia-inducible factor-la in the brain of rats during chronic hypoxia. J Appl Physiol 2000; 89:1937–1942.
Bergeron M, Yu AY, Solway KE et al. Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eur J Neurosci 1999; 11:4159–4170.
Jin KL, Mao XO, Nagayama T et al. Induction of vascular endothelial growth factor and hypoxia-inducible factor-la by global ischemia in rat brain. Neuroscience 2000; 99:577–585.
Marti HJH, Bernaudin M, Bellail A et al. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol 2000; 156:965–976.
Papavassiliou E, Gogate N, Proescholdt M et al. Vascular endothelial growth factor (vascular permeability factor) expression in injured rat brain. J Neurosci Res 1997; 49:451–460.
Bartholdi D, Rubin BP, Schwab ME. VEGF mRNA induction correlates with changes in the vascular architecture upon spinal cord damage in the rat. Eur J Neurosci 1997; 9:2549–2560.
Sk Id M, Cullheim S, Hammarberg H et al. Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administration. Eur J Neurosci 2000; 12:3675–3686.
Tuder RM, Flook BE, Voelkel NF. Increased gene expression for VEGF and the VEGF receptors KDR/flk and flt in lungs exposed to acute or chronic hypoxia, Modulation of gene expression by nitric oxide. J Clin Invest 1995; 95:1798–1807.
Jin KL, Mao XO, Nagayama T et al. Induction of vascular endothelial growth factor receptors and phosphatidylinositol 3 -kinase/Akt signaling by global cerebral ischemia in the rat. Neuroscience 2000; 100:713–717.
Gerber H-P, Condorelli F, Park J et al. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes; flt-1, but not flk- 1/KDR, is up-regulated by hypoxia. J Biol Chem 1997; 272:23659–23667.
Li J, Brown LF, Hibberd MG et al. VEGF, Jik-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis. Am J Physiol 1996; 270:H1803–H1811.
Kappel A, R nicke V, Damert A et al. Identification of vascular endothelial growth factor (VEGF) receptor-2 (Flk-1) promoter/enhancer sequences sufficient for angioblast and endothelial cell-specific transcription in transgenic mice. Blood 1999; 93:4284–4292.
Kremer C, Breier G, Risau W et al. Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system. Cancer Res 1997; 57:3852–3859.
Shen B-Q, Lee DY, Gerber H-P et al. Homologous up-regulation of KDR/FIk-1 receptor expression by vascular endothelial growth factor in vitro. J Biol Chem 1998; 273:29979–29985.
Zhang ZG, Tsang W, Zhang L et al. Up-regulation of neuropilin-1 in neovasculature after focal cerebral ischemia in the adult rat. J Cereb Blood Flow Metab 2001; 21:541–549.
Gleadle JM, Ebert BL, Firth JD et al. Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. Am J Physiol 1995; 268:C1362–C1368.
Enholm B, Paavonen K, Ristimaki A et al. Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 m-RNA regulation by serum, growth factors, oncoproteins and hypoxia. Oncogene 1997; 14:2475–2483.
Zhu H, Bunn HF. How do cells sense oxygen? Science 2001; 292:449–451.
Lennmyr F, Ata KA, Funa K et al. Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) following permanent and transient occlusion of the middle cerebral artery in the rat. J Neuropathol Exp Neurol 1998; 57:874–882.
Yang XJ, Cepko CL. Flk-1, a receptor for vascular endothelial growth-factor (VEGF), is expressed by retinal progenitor cells. J Neurosci 1996; 16:6089–6099.
Rosenstein JM, Mani N, Silverman WF et al. Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo. Proc Natl Acad Sei USA 1998; 95:7086–7091.
Krum JM, Rosenstein JM, VEGF mRNA and its receptor Jit-I are expressed in reactive astrocytes following neural grafting and tumor cell implantation in the adult CNS. Exp Neurol 1998; 154:57–65.
Sondell M, Lundborg G, Kanje M. Vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system. J Neurosci 1999; 19:5731–5740.
Silverman WF, Krum JM, Mani N et al. Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures. Neuroscience 1999; 90:1529–1541.
Temburni MK, Jacob MH. New functions for glia in the brain. Proc Natl Acad Sci USA 2001; 98:3631–3632.
Robinson GS, Ju M, Shih S-C, Xu X, Mcmahon G, Caldwell R, Smith LEH. Nonvascular role for VEGF:VEGFR-1, 2 activity is critical for neural retinal development. FASEB J (March 20, 2001) I0.1096/ü1.00–0598ü1e.
Yourey PA, Gohari S, Su JL et al. Vascular endothelial cell growth factors promote the in vitro development of rat photoreceptor cells. J Neurosci 2000; 20:6781–6788.
lin KL, Mao XO, Greenberg DA. Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc Natl Acad Sci USA 2000; 97:10242–10247.
Matsuzaki H, Tamatani M, Yamaguchi A, Namikawa K, Kiyama H, Vitek MP et al. Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: Signal transduction cascades. FASEB J (March 12, 2001) 10.1096/1.00–0495ü1e.
Hayashi T, Abe K, Itoyama Y. Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia. J Cereb Blood Flow Metab 1998; 18:887–895.
Sondell M, Kanje M. Postnatal expression of VEGF and its receptor flk-1 in peripheral ganglia. Neuroreport 2001; 12:105–108.
Sondell M, Lundborg G, Kanje M. Vascular endothelial growth factor stimulates Schwann cell invasion and neovascularization of acellular nerve grafts. Brain Res 1999; 846:219–228.
Sondell M, Sundler F, Kanje M. Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor. Eur J Neurosci 2000; 12:4243–4254.
Schratzberger P, Schratzberger G, Silver M et al. Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy. Nature Med 2000; 6:405–413.
Schratzberger P, Walter DH, Rittig K et al. Reversal of experimental diabetic neuropathy by VEGF gene transfer. J Clin Invest 2001; 107:1083–1092.
Oosthuyse B, Moons L, Storkebaum E et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet 2001; 28:131–138.
Bagnard D, Vaillant C, Khuth S-T et al. Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor. J Neurosci 2001; 21:3332–3341.
Fuh G, Garcia KC, de Vos AM. The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor Flt-1. J Biol Chem 2000; 275:26690–26695.
Risau W, Flamme I. Vasculogenesis. Annu Rev Cell Dev Biol 1995; 11:73–91.
Asahara T, Takahashi T, Masuda H et al. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO J 1999; 18:3964–3972.
Risau W. Mechanisms of angiogenesis. Nature 1997; 386:671–674.
Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995; 1:27–31.
Buschmann I, Schaper W. Arteriogenesis versus angiogenesis: Two mechanisms of vessel growth. News Physiol Sei 1999; 14:121–125.
Hank SI, Hritz MA, LaManna JC. Hypoxia-induced brain angiogenesis in the adult rat. J Physiol (London) 1995; 485:525–530
Boero JA, Ascher J, Arregui A et al. Increased brain capillaries in chronic hypoxia. J Appl Physiol 1999; 86:1211–1219.
LaManna JC, Harik SI. Brain metabolic and vascular adaptations to hypoxia in the rat. Adv Exp Med Biol 1997; 428:163–167.
Kuo N-T, Benhayon D, Przybylski RJ et al. Prolonged hypoxia increases vascular endothelial growth factor mRNA and protein in adult mouse brain. J Appl Physiol 1999; 86:260–264.
Marti HH, Bernaudin M, Petit E et al. Neuroprotection and angiogenesis: A dual role of erythropoietin in brain ischemia. News Physiol Sci 2000; 15:225–229.
Greenberg DA. Angiogenesis and stroke. Drug News Perspect 1998; 11:265–270.
Ment LR, Stewart WB, Fronc R et al. Vascular endothelial growth factor mediated reactive angiogenesis in the postnatal developing brain. Develop Brain Res 1997; 100:52–61.
van Bruggen N, Thibodeaux H, Palmer JT et al. VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain. J Clin Invest 1999; 104:1613–1620.
Zhang ZG, Zhang L, Jiang Q et al. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest 2000; 106:829–838.
Eliceiri BP, Paul R, Schwartzberg PL et al. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell 1999; 4:915–924.
Paul R, Zhang ZG, Eliceiri BP et al. Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke. Nature Med 2001; 7:222–227.
Gerber HP, McMurtrey A, Kowalski J et al. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3’-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem 1998; 273:30336–30343.
Jin KL, Mao XO, Greenberg DA. Vascular endothelial growth factor rescues HN33 neural cells from death induced by serum withdrawal. J Mol Neurosci 2000; 14:197–203.
Kalaria RN, Cohen DL, Premkumar DRD et al. Vascular endothelial growth factor in Alzheimer s disease and experimental cerebral ischemia. Mol Brain Res 1998; 62:101–105.
Thurston G, Rudge JS, Ioffe E et al. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nature Med 2000; 6:460–463.
Celletti FL, Waugh JM, Amabile PG et al. Vascular endothelial growth factor enhances atherosclerotic plaque progression. Nature Med 2001; 7:425–429.
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Marti, H.H. (2003). Vascular Endothelial Growth Factor. In: Alzheimer, C. (eds) Molecular and Cellular Biology of Neuroprotection in the CNS. Advances in Experimental Medicine and Biology, vol 513. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0123-7_14
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