Abstract
Objectives: Evaluation of the cerebrovascular response (∆CBV/∆Paco2)during baseline metabolic conditions and acute metabolic acidosis. Methods: 15 healthy subjects, 5 m, 10 f, 56±10 yrs were investigated. For acidification, NH4CI was given orally. CBV was measered using Near Infrared Spectroscopy (OXYMON) during normo-, hyper- and hypocapnia. Results: Acute metabolic acidosis was realised: mean ΔBE -2.7 mEq.L-1 (p<0.001) with mean ∆Paco2-0.2 kPa (p<0.01). During normo-, hyper- and hypocapnia, CBV values of 3.51, 4.82 and 2.55 mL.100g-1 were calculated during baseline metabolic conditions and 3.70, 4.86 and 2.63 niL.100g-1 during acute metabolic acidosis. The CBV/Paco2 response showed a hockeystick configuration with the point of infliction around normocapnia. ∆CBV/∆Paco2 reactivity from normo-to hypercapnia and from normo-to hypocapnia was calculated; no significant differences in ∆CBV/∆Paco2 were found in both metabolic conditions. Conclusion: Cerebrovascular reactivity to CO2 does not alter during acute metabolic acidosis.
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van de Ven, M., Colier, W.N.J.M., Kersten, B.T.P., Oeseburg, B., Folgering, H. (2003). Cerebrovascular Response to Acute Metabolic Acidosis in Humans. In: Dunn, J.F., Swartz, H.M. (eds) Oxygen Transport to Tissue XXIV. Advances in Experimental Medicine and Biology, vol 530. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0075-9_71
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DOI: https://doi.org/10.1007/978-1-4615-0075-9_71
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