Abstract
Impaired molecular regulation of active (programmed) cell death is one of the most important hallmark of cancer. Apoptosis is the best characterized biochemical and morphological form of cell death, although other forms also exist. Positive regulators of apoptosis are often lost or inactivated, while inhibitor proteins of apoptosis are often upregulated in cancer. Individual variabilities in these molecular strategies contribute to the differences in sensitivity to current anti-cancer therapies and also provide new existing molecular targets for future therapeutic approaches.
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Kopper, L., Peták, I. (2008). Apoptosis and cancer. In: Kaiser, H.E., Nasir, A. (eds) Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response. Cancer Growth and Progression, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6729-7_7
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DOI: https://doi.org/10.1007/978-1-4020-6729-7_7
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