Abstract
Distinguishable differences between infecting organisms and their respective hosts with respect to metabolism and macromolecular structure provide scopes for detailed characterization of target proteins and/or macromolecules as the focus for the devel opment of selective inhibitors. In order to develop a rational approach to antiparasitic chemo therapy, finding differences in the biochemical pathways of the parasite with respect to the host it infects is therefore of primary importance. Like most parasitic protozoan, the genus Leishmania is an obligate auxotroph of purines and hence for requirement of purine bases depends on its own purine salvage pathways.
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Datta, A.K., Datta, R., Sen, B. (2008). Antiparasitic Chemotherapy:. In: Majumder, H.K. (eds) Drug Targets in Kinetoplastid Parasites. Advances In Experimental Medicine And Biology, vol 625. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77570-8_10
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DOI: https://doi.org/10.1007/978-0-387-77570-8_10
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