Abstract
The synthesis and study of dendrimers has been truly dramatic in the last ten years. This review gives a brief introduction to some of the key concepts and main synthetic strategies in dendrimer chemistry. The focus of the chapter is a survey of modern analytical techniques and physical characterization of dendrimers. Results of model calculations and experiments probing the dimensions and conformation of dendrimers are reviewed. In the final sections the experimental work on dendrimer-polymer hybrids is highlighted. The dense spherical conformation of dendrimers has been combined with the loose random-coil conformation of ordinary polymers to form new hybrids with potentially interesting new properties.
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References
Corey EJ, Cheng XM (1989) The logic of chemical synthesis. Wiley, New York
Buhleier E, Wehner W, Vögtle F (1978) Synthesis 155
Tomalia DA, Baker H, Dewald J, Hall M, Kallos G, Martin S, Roeck J, Ryder J, Smith P (1985) Polymer J 17:117
Wörner C, Mülhaupt R (1993) Angew Chem Int Ed Engl 32:1306
de Brabander-van den Berg EMM, Meijer EW (1993) Angew Chem Int Ed Engl 32:1308
de Brabander EMM, Brackman J, Mure-Mak M, de Man H, Hogeweg M, Keulen J, Scherrenberg R, Coussens B, Mengerink Y, van den Wal Sj (1996) Macromol Symp 102:9
Smith PB, Martin SJ, Hall MJ, Tomalia DA (1988) Appl Polym Analysis Charact 2:357
Newkome GR, Yao Z, Baker GR, Gupta VK (1985) J Org Chem 50:2003
Miller TM, Neenan TX (1990) Chem Mater 2:346
Hawker CJ, Fréchet JMJ (1990) J Am Chem Soc 112:7638
Wooley KL, Hawker CJ, Fréchet JMJ (1991) J Am Chem Soc 113:4252
Spindler R, Fréchet JMJ (1993) J Chem Soc, Perkin Trans I:913
Leon JW, Kawa M, Fréchet JMJ (1996) J Am Chem Soc 118:8847
Wooley KL, Hawker CJ, Fréchet JMJ (1994) Angew Chem Int Ed Engl 33:82
L’abbé G, Forier B, Dehaen W (1996) Chem Commun 2143
Chang H-T, Chen C-T, Kondo T, Siuzdal G, Sharpless KB (1996) Angew Chem Int Ed Engl 35:182
Kawachugi T, Walker KL, Wilkins CL, Moore JS (1995) J Am Chem Soc 117:2159
Tomalia DA, Naylor MA, Goddard WA III (1990) Angew Chem Int Ed Engl 29:138
Tomalia DA, Hedstrand DM, Wilson LR (1990). In: Mark HF, Bikales NM, Overberger CG, Mendes G (eds) Encyclopedia of polymer science and technology, 2nd edn, index volume. Wiley, New York
Mekelburger H-B, Jaworek W, Vögtle F (1992) Angew Chem Int Ed Engl 31:1571
Tomalia DA, Durst HD (1993) Topics in Current Chemistry 165:197
Issberner J, Moors R, Vögtle F (1994) Angew Chem Int Ed Engl 33:2413
Ardoin N, Astruc D (1995) Bull Soc Chim Fr 132:875
Voit BH (1995) Acta Polym 46:87
Newkome GR, Moorefield CN, Vögtle F (1996) Dendritic molecules: concept, synthesis, perspectives. VCH, Weinheim
Fréchet JMJ, Hawker CJ (1996). In: G Allen (ed) Comprehensive polymer science, 2nd suppl. Pergamon Elsevier Science, Oxford
Zeng F, Zimmerman SC (1997) Chem Rev 97:1681
Peerlings HWI, Meijer EW (1997) Chem Eur J 3:1563
Matthews OA, Shipway AN, Stoddart JF (1998) Progr Polym Sci 23:1
Newkome GR (ed) (1994–1996) Advances in dendritic macromolecules. vols 1–3. JAI Press, Greenwich, CT
Buyle Padias A, Hall HK Jr, Tomalia DA, McConnell JR (1987) J Org Chem 52:5305
Seyferth D, Son DY, Rheingold AL, Ostrander RL (1994) Organometallics 13:2682
van Genderen MHP, Baars MWPL, van Hest JCM, de Brabander-van den Berg EMM, Meijer EW (1994) Rec Trav Chim Pays-Bas 113:573
Kallos GJ, Tomalia DA, Hedstrand DM, Lewis S, Zhou J (1991) Rapid Commun Mass Spectrom 5:383
Schwartz BL, Rockwood AL, Smith RD, Tomalia DA, Spindler R (1995) Rapid Commun Mass Spectrom 9:1552
Hummelen JC, van Dongen JLJ, Meijer EW (1997) Chem Eur J 3:1489
Stöckigt D, Lohmer G, Belder D (1996) Rapid Commun Mass Spectrom 10:521
van Hest JCM, Delnoye DAP, Baars HWPL, Elissen-Romàn C, van Genderen MHP, Meijer EW (1996) Chem Eur J 2:1616
Sahota HS, Lloyd PM, Yeates SG, Derrick PJ, Taylor PC, Haddleton DM (1994) J Chem Soc, Chem Commun 2445
Leon JW, Fréchet JMJ (1995) Polym Bull 35:449
Szwarc M (1968) Carbanion, living polymer and electron transfer processes. Inter-science Publ, New York
Frey H, Lorenz K, Mülhaupt R, Rapp U, Mayer-Posner FJ (1996) Macromol Symp 102:19
Martinez CA, Hay AS (1997) J Polym Sci: A: Polym Chem 35:1781
Xu Z, Kahr M, Walker KL, Wilkins CL, Moore JS (1994) J Am Chem Soc 116:4537
Walker KL, Kahr MS, Wilkins CL, Xu Z, Moore JS (1994) J Am Soc Mass Spectrom 5:731
Hayes W, Freeman AW, Fréchet JMJ (1997) PMSE Preprints 77:136
McCrackin FL, Wagner HL (1980) Macromolecules 13:685
Mourey TH, Turner SR, Rubinstein M, Fréchet JMJ, Hawker CJ, Wooley KL (1992) Macromolecules 25:2401
de Gennes P-G, Hervet H (1983) J Phys Lett 44:L351
Maciejewski M (1982) J Macromol Sci Chem Phys A17:689
Lescanec RL, Muthukumar M (1990) Macromolecules 23:2280
Mansfield ML, Klushin LI (1993) Macromolecules 26:4262
Boris D, Rubinstein M (1996) Macromolecules 29:7251
Murat M, Grest GS (1996) Macromolecules 29:1278
Zimm B, Stockmayer WH (1949) J Chem Phys 17:1301
Kurata M, Abe M, Iwana M, Matsushima M (1972) Polym J 3:729
Naylor AM, Goddard WA III, Kiefer GE, Tomalia DA (1989) J Am Chem Soc 111:2339
Mansfield ML (1994) Polymer 35:1827
Mansfield ML, Klushin LI (1992) J Phys Chem 96:3994
Chen ZY, Cui S-M (1996) Macromolecules 29:7943
Lue L, Prausnitz JM (1997) Macromolecules 30:6650
Huber K, Burchard W, Fetters LJ (1984) Macromolecules 17:541
Richter D, Farago B, Fetters LJ, Huang JS, Ewen B (1990) Macromolecules 23:1845
Bauer BJ, Fetters LJ, Graessley WW, Hadjichristidis N, Quack GE (1989) Macromolecules 22:2337
Roovers J (1999). In: Mishra MK, Kobayashi S (eds) Star and hyperbranched polymers. Marcel Dekker, New York
Roovers J, Zhou L-L, Toporowski PM, van der Zwan M, Iatrou H, Hadjichristidis N (1993) Macromolecules 26:4324
Burchard W, Kajiwara K, Nerger D (1982) J Polym Sci, Polym Phys Ed 20:157
Hammouda B (1992) J Polym Sci: Part B: Polym Phys 30:1387
Aharoni SM, Murthy NS (1983) Polym Commun 24:132
Bauer BJ, Topp A, Prosa TJ, Amis EJ, Yin R, Qin D, Tomalia DA (1997) PMSE Preprints 77:87
de Brabander E, Brackman J, Froehling P, Scherrenberg R, Put J (1997) PMSE Preprints 77:84
Aharoni SM, Crosby CR III, Walsh EK (1982) Macromolecules 15:1093
Tomalia DA, Hall M, Hedstrand DM (1987) J Am Chem Soc 109:1601
Einaga Y, Koyama H, Konishi T, Yamakawa H (1989) Macromolecules 22:3419
Hawker CJ, Malmström EE, Franck CW, Kampf JP (1997) J Am Chem Soc 119:9903
Stechemesser S, Eimer W (1997) Macromolecules 30:2204
Tomalia DA, Berry V, Hall M, Hedstrand DM (1987) Macromolecules 20:1164
de Brabander-van den Berg EMM, Nijenhuis A, Mure M, Keulen J, Reintjens R, Vandenbooren F, Bosman B, de Raat R, Frijns T, van de Wal S, Castelijns M, Put J, Meijer EW (1994) Macromol Symp 77:51
Zhou L-L, Roovers J (1993) Macromolecules 26:963
Morikawa A, Kakimoto M, Imai Y (1991) Macromolecules 24:3469
Roovers J (1996) In: Salamone JC (ed) Polymer materials encyclopedia, vol 1. CRC Press, Boca Raton, p 850
Kato Y, Itsubo A, Yamamoto Y, Fujimoto T, Nagasawa M (1975) Polymer J 7:123
Newkome GR, Young JK, Baker GR, Potter RL, Audoly L, Cooper D, Weiss CD, Morris K, Johnson CS Jr (1993) Macromolecules 26:2394
Young JK, Baker GR, Newkome GR, Morris KF, Johnson CS Jr (1994) Macromolecules 27:3463
Dubin PL, Edwards SL, Kaplan JI, Mehta MS, Tomalia DA, Xia J (1992) Anal Chem 64:2344
Gauthier M, Möller M (1991) Macromolecules 24:4548
Tomalia DA, Hedstrand DM, Ferritto MS (1991) Macromolecules 24:1435
Gauthier M, Möller M, Burchard W (1994) Macromol Symp 77:43
Yin R, Swanson DR, Tomalia DA (1995) PMSE Preprints 73:277
Sheiko SS, Gauthier M, Möller M (1997) Macromolecules 30:2343
Hempenius MA, Michelberger W, Möller M (1997) Macromolecules 30:5602
Gauthier M, Li W, Tichagwa L (1995) PMSE Preprints 73:232
Candau F, Rempp P, Benoit H (1972) Macromolecules 5:627
Kee RA, Gauthier M (1995) PMSE Preprints 73:335
Gauthier M, Tichagwa L, Downey JS, Gao S (1996) Macromolecules 29:519
Grubbs RB, Hawker CJ, Dao J, Fréchet JMJ (1997) Angew Chem Int Ed Engl 36:270
Six JL, Gnanou Y (1995) Macromol Symp 95:137
Zimm BH, Stockmayer WH (1949) J Chem Phys 17:1301
Bera TK, Taton D, Gnanou Y (1997) PMSE Preprints 77:126
Cloutet E, Six JL, Taton D, Gnanou Y (1995) PMSE 73:133
Wang F, Roovers J, Toporowski PM (1995) Macromol Reports A32(5&6):951
Wintermantel M, Schmidt M, Tsukahara Y, Kajiwara K, Kohiya S (1994) Macromol Rapid Commun 15:279
Wintermantel M, Gerle M, Fischer K, Schmidt M, Wataoka I, Urakawa H (1996) Macromolecules 29:978
Wintermantel M, Fischer K, Gerle M, Schmidt M, Kajiwara K, Urakawa H, Wataoka I (1995) Angew Chem Int Ed Engl 34:1472
Flory PJ (1956) Proc Roy Soc London Ser A 234:73
Percec V, Heck J, Tomazos D, Falkenberg F, Blackwell H, Ungar G (1993) J Chem Soc Perkin Trans I2799
Hawker CJ, Fréchet JMJ (1992) Polymer 33:1507
Neubert I, Amoulong-Kirstein E, Schlüter A-D, Dautzenberg H (1996) Macromol Rapid Commun 17:517
Neubert I, Klopsch R, Claussen W, Schlüter A-D, (1996) Acta Polym 47:455
Fréchet JMJ, Gitsov I (1995) Macromol Symp 98:441
Chen YM, Chen CF, Liu WH, Li YF, Xi F (1996) Macromol Rapid Commun 17:401
Draheim G, Ritter H (1995) Macromol Chem Phys 196:2211
Karakaya B, Claussen W, Gessler K, Saenger W, Schlüter A-D (1997) J Am Chem Soc 119:3296
Claussen W, Schulte N, Schlüter A-D (1995) Macromol Rapid Commun 16:89
Kaneko T, Horie T, Asano M, Aoki T, Oikawa E (1997) Macromolecules 30:3118
Freudenberger R, Claussen W, Schlüter A-D, Wallmeier H (1994) Polymer 35:4495
Karakaya B, Claussen W, Schäfer A, Lehmann A, Schlüter A-D (1996) Acta Polym 47:49
Gitsov I, Wooley KL, Fréchet JMJ (1992) Angew Chem Int Ed Engl 31:1200
Gitsov I, Fréchet JMJ (1993) Macromolecules 26:6536
Gitsov I, Wooley KL, Hawker CJ, Ivanova PT, Fréchet JMJ (1993) Macromolecules 26:5621
Fréchet JMJ, Gitsov I (1995) Macromol Symp 98:441
Gitsov I, Fréchet JMJ (1996) J Am Chem Soc 118:3785
Wooley KL, Fréchet JMJ (1992) PMSE Preprints 67:90
Gitsov I, Fréchet JMJ (1994) Macromolecules 27:7309
Gitsov I, Ivanova PT, Fréchet JMJ (1994) Macromol Rapid Commun 15:387
Leduc MR, Hawker CJ, Dao J, Fréchet JMJ (1996) J Am Chem Soc 118:11, 111
Matyjaszewski K, Shigemoto T, Fréchet JMJ, Leduc M (1996) Macromolecules 29:4167
Amabilino DB, Ashton PR, Balzani V, Brown CL, Credi A, Fréchet JMJ, Leon JW, Raymo FM, Spencer N, Stoddart JF, Venturi M (1996) J Am Chem Soc 118:12, 012
Chapman TM, Hillyer GL, Mahan EJ, Shaffer KA (1994) J Am Chem Soc 116:11, 195
van Hest JCM, Baars MWPL, Elissen-Román C, van Genderen MHP, Meijer EW (1995) Macromolecules 28:6689
van Hest JCM, Delnoye DAP, Baars MWPL, van Genderen MHP, Meier EW (1995) Science 268:1592
Aoi K, Motada A, Okada M, Imae T (1997) Macromol Rapid Commun 18:945
Chang JY, Ji HJ, Han MJ, Rhee SB, Cheong S, Yoon M (1994) Macromolecules 27:1376
Slany M, Bardaji M, Caminade A-M, Chaudret B, Majoral JP (1997) Inorg Chem 36:1939
Nijenhuis A (1997) private communication
Warakomski J (1992) Chem Mat 4:1000
Risch BG, Wilkes GL, Warakomski JM (1993) Polymer 34:2330
Yen DR, Merrill EW (1997) Polymer Preprints 38:531
Fetters LJ, Hadjichristidis N (1980) Macromolecules 13:191
Zhou L-L, Hadjichristidis N, Toporowski PM, Roovers J (1992) Rubber Chem Techn 65:303
Roovers J (1994) Macromolecules 27:5359
Avgeropoulos A, Poulos Y, Hadjichristidis N, Roovers J (1996) Macromolecules 29:6076
van Aert HAM, Burkard MEM, Jansen JFGA, van Genderen MHP, Meijer EW, Oevering H, Buning GHW (1995) Macromolecules 28:7967
van Aert HAM, van Genderen MHP, Meijer EW (1996) Polym Bull 37:273
Tam JP (1988) Proc Natl Acad Sci USA 85:5409
Posnett DN, McGrath H, Tam JP (1988) J Biol Chem 263:1719
Chang K-J, Pugh W, Blanchard SG, McDermed J, Tam JP (1988) Proc Natl Acad Sci USA 85:4929
Defoort J-P, Nardelli B, Huang W, Ho DD, Tam JP (1992) Proc Natl Acad Sci USA 89:3879
Rao C, Tam JP (1994) J Am Chem Soc 116:6975
Shao J, Tam JP (1995) J Am Chem Soc 117:3893
Spetzler J, Tam JP (1995) Int J Pept Protein Res 45:78
Delong R, Stephenson K, Loftus T, Fisher M, Alahari S, Nolting A, Juliano RL (1997) J Pharmac Sci 86:762
Poxon SW, Mitchell PM, Liang E, Hughes JA (1996) Drug Delivery 3:255
Bielinska A, Kukowska-Latallo JF, Johnson J, Tomalia DA, Baker JR Jr (1996) Nucleic Acids Res 24:2176
Kukowska-Latallo JF, Bielinska AU, Johnson J, Spindler R, Tomalia DA, Baker JR Jr (1996) Proc Natl Acad Sci 93:4897
Haensler J, Szoka FC Jr (1993) Bioconjugate Chem 4:372
Bielinska AU, Kukowska-Latallo JF, Baker JR Jr (1997) Biochim Biophys Acta 1353:180
Tang MX, Redemann CT, Szoka FC Jr (1996) Bioconjugate Chem 7:703
Roberts JC, Adams YE, Tomalia DA, Mercer-Smith JA, Lavallee DK (1990) Bioconjugate Chem 1:305
Wu C, Brechbiel MW, Kozak RW, Gansow OA (1994) Bioorg Med Chem Lett 4:449
Barth RF, Adams DM, Soloway AH, Alam F, Darby MV (1994) Bioconjugate Chem 5:58
Capala J, Barth RF, Bendayan M, Lauzon M, Adams DM, Soloway AH, Fenstermacher RA, Carlsson J (1996) Bioconjugate Chem 7:7
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Roovers, J., Comanita, B. (1999). Dendrimers and Dendrimer-Polymer Hybrids. In: Roovers, J. (eds) Branched Polymers I. Advances in Polymer Science, vol 142. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-68310-0_4
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