Abstract
The domestic cats (Catus domesticus) from which feline immunodeficiency virus (FIV) was first isolated showed clinical signs of immunodeficiency, and the incidence of disease was associated with the prevalence of FIV. The first publication by Niels Pedersen and his collegues1 at the University of California describes a number of important genomic, structural, and biochemical characteristics of the virus that were found to be remarkably similar to human immunodeficiency virus (HIV). During the past two decades, FIV infection in the domestic cat has become an excellent comparative model for studying several aspects of HIV biology, vaccine development, and particularly immunopathogenesis. Although the lentiviruses genetically most closely related to FIV are those of the small ruminants, maedi-visna virus of sheep, and caprine arthritis encephalitis virus, the type of disease produced by FIV is remarkably similar to acquired immunodeficiency syndrome (AIDS) in humans.
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Keywords
- Treg Cell
- Feline Immunodeficiency Virus
- Equine Infectious Anaemia Virus
- Plasma Viremia
- Feline Immunodeficiency Virus Infection
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Vahlenkamp, T.W., Tompkins, M.B., Tompkins, W.A.F. (2006). FIV as a Model for AIDS Pathogenesis Studies. In: Friedman, H., Specter, S., Bendinelli, M. (eds) In vivo Models of HIV Disease and Control. Infectious Diseases and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/0-387-25741-1_8
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