Collection
Understanding and overcoming the mechanisms driving age-related sarcopenia
- Submission status
- Open
- Open for submission from
- 01 January 2019
- Submission deadline
- Ongoing
Guest Editors Drs. Paul Greenhaff, Janet M Lord and Niharika Duggal and Editor-in-Chief Dr. Zoltan Ungvari, and the editorial team of GeroScience invite submission of original research articles, opinion papers and review articles related to research focused on understanding the mechanisms that underlie age-related loss of muscle mass and strength (sarcopenia) and how to prevent this.
Editors
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Paul Greenhaff
University of Nottingham, UK
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Janet M Lord
University of Birmingham, UK
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Niharika Duggal
University of Birmingham, UK
Articles (64 in this collection)
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Lower muscle mitochondrial energetics is associated with greater phenotypic frailty in older women and men: the Study of Muscle, Mobility and Aging
Authors (first, second and last of 15)
- Theresa Mau
- Haley N. Barnes
- Peggy M. Cawthon
- Content type: Original Article
- Published: 21 November 2023
- Pages: 2409 - 2424
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Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice
Authors (first, second and last of 17)
- Georgia L. Nolt
- Alexander R. Keeble
- Cory M. Dungan
- Content type: ORIGINAL ARTICLE
- Open Access
- Published: 24 October 2023
- Pages: 2153 - 2176
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Greater myofibrillar protein synthesis following weight-bearing activity in obese old compared with non-obese old and young individuals
Authors (first, second and last of 7)
- Paul T. Morgan
- Benoit Smeuninx
- Leigh Breen
- Content type: ORIGINAL ARTICLE
- Open Access
- Published: 17 June 2023
- Pages: 3759 - 3778
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Physical activity intensity, frequency, duration, volume and the risk of possible sarcopenia in middle-aged and older adults
Authors (first, second and last of 5)
- Xiaoguang Zhao
- Hongjun Zhang
- Jin Wang
- Content type: ORIGINAL ARTICLE
- Published: 04 June 2023
- Pages: 3743 - 3757
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Sex-specific alteration in human muscle transcriptome with age
Authors (first, second and last of 9)
- Mohini Gharpure
- Jie Chen
- Sadanand Fulzele
- Content type: ORIGINAL ARTICLE
- Published: 27 April 2023
- Pages: 1303 - 1316
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Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice
Authors (first, second and last of 7)
- Matthew D. Campbell
- Ashton T. Samuelson
- David J. Marcinek
- Content type: Original Article
- Published: 25 February 2023
- Pages: 2245 - 2255
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Sex differences in skeletal muscle-aging trajectory: same processes, but with a different ranking
Authors (first, second and last of 10)
- Jelle C.B.C. de Jong
- Brecht J. Attema
- Jaap Keijer
- Content type: Original Article
- Open Access
- Published: 23 February 2023
- Pages: 2367 - 2386
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Genes encoding agrin (AGRN) and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration
Authors (first, second and last of 9)
- Jedd Pratt
- Laura Whitton
- Colin Boreham
- Content type: ORIGINAL ARTICLE
- Open Access
- Published: 07 January 2023
- Pages: 1289 - 1302
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Altered T cell infiltration and enrichment of leukocyte regulating pathways within aged skeletal muscle are associated impaired muscle function following influenza infection
Authors (first, second and last of 8)
- Spencer R. Keilich
- Andreia N. Cadar
- Jenna M. Bartley
- Content type: Original Article
- Published: 29 December 2022
- Pages: 1197 - 1213
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Fast and slow skeletal myosin binding protein-C and aging
Authors
- L. R. Perazza
- G. Wei
- L. V. Thompson
- Content type: Original Article
- Open Access
- Published: 21 November 2022
- Pages: 915 - 929
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Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study
Authors (first, second and last of 11)
- Roger A. Fielding
- Elizabeth J. Atkinson
- Nathan K. LeBrasseur
- Content type: Original Article
- Open Access
- Published: 11 November 2022
- Pages: 2757 - 2770
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Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles
Authors (first, second and last of 10)
- Allen Herbst
- Judd M. Aiken
- Jonathan Wanagat
- Content type: Original Article
- Published: 30 September 2022
- Pages: 555 - 567
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Proteomic features of skeletal muscle adaptation to resistance exercise training as a function of age
Authors (first, second and last of 11)
- Colleen S. Deane
- Bethan E. Phillips
- Timothy Etheridge
- Content type: Original Article
- Open Access
- Published: 26 September 2022
- Pages: 1271 - 1287
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Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle
Authors (first, second and last of 11)
- Matthew S. Brook
- Daniel J. Wilkinson
- Philip J. Atherton
- Content type: OriginalPaper
- Open Access
- Published: 09 September 2022
- Pages: 451 - 462
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CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice
Authors (first, second and last of 6)
- Sara López-Bellón
- Sandra Rodríguez-López
- José M. Villalba
- Content type: Original Article
- Open Access
- Published: 09 May 2022
- Pages: 2223 - 2241
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Obesity as a premature aging phenotype — implications for sarcopenic obesity
Authors (first, second and last of 8)
- Emily Nunan
- Carson L. Wright
- Joshua T. Butcher
- Content type: Review
- Open Access
- Published: 26 April 2022
- Pages: 1393 - 1405
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Longitudinal associations between blood lysophosphatidylcholines and skeletal muscle mitochondrial function
Authors (first, second and last of 4)
- Qu Tian
- Brendan A. Mitchell
- Luigi Ferrucci
- Content type: Original Article
- Open Access
- Published: 07 April 2022
- Pages: 2213 - 2221
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Senolytic treatment rescues blunted muscle hypertrophy in old mice
Authors (first, second and last of 14)
- Cory M. Dungan
- Vandre C. Figueiredo
- Charlotte A. Peterson
- Content type: Original Article
- Open Access
- Published: 24 March 2022
- Pages: 1925 - 1940
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The Combined Oral Stable Isotope Assessment of Muscle (COSIAM) reveals D-3 creatine derived muscle mass as a standout cross-sectional biomarker of muscle physiology vitality in older age
Authors (first, second and last of 9)
- Jessica Cegielski
- Matthew S. Brook
- Philip J. Atherton
- Content type: Original Article
- Open Access
- Published: 18 March 2022
- Pages: 2129 - 2138
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Cardiac troponin T and autoimmunity in skeletal muscle aging
Authors (first, second and last of 10)
- Tan Zhang
- Xin Feng
- Stephen Kritchevsky
- Content type: Original Article
- Published: 15 January 2022
- Pages: 2025 - 2045
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A neuromuscular perspective of sarcopenia pathogenesis: deciphering the signaling pathways involved
Authors (first, second and last of 4)
- Alexandra Moreira-Pais
- Rita Ferreira
- José A. Duarte
- Content type: Original Article
- Published: 04 January 2022
- Pages: 1199 - 1213
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Pharmacologic treatment with OKN-007 reduces alpha-motor neuron loss in spinal cord of aging mice
Authors (first, second and last of 5)
- Katarzyna M. Piekarz
- Constantin Georgescu
- Holly Van Remmen
- Content type: Original Article
- Published: 04 January 2022
- Pages: 67 - 81
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Intrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults
Authors (first, second and last of 6)
- Lucas B. R. Orssatto
- David N. Borg
- Gabriel S. Trajano
- Content type: Original Article
- Published: 30 October 2021
- Pages: 2719 - 2735
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Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults
Authors (first, second and last of 6)
- Philip J. J. Herrod
- Philip J. Atherton
- Bethan E. Phillips
- Content type: Original Article
- Open Access
- Published: 25 September 2021
- Pages: 2667 - 2678
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Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels
Authors (first, second and last of 11)
- Ryan Frankum
- Tom S. O. Jameson
- Lorna W. Harries
- Content type: Original Article
- Open Access
- Published: 26 August 2021
- Pages: 1129 - 1140
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Reversal of deficits in aged skeletal muscle during disuse and recovery in response to treatment with a secrotome product derived from partially differentiated human pluripotent stem cells
Authors (first, second and last of 10)
- Dennis K. Fix
- Ziad S. Mahmassani
- Micah J. Drummond
- Content type: Original Article
- Open Access
- Published: 24 August 2021
- Pages: 2635 - 2652
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Eat like an athlete: insights of sports nutrition science to support active aging in healthy older adults
Authors (first, second and last of 4)
- Sara Y. Oikawa
- Tristin D. Brisbois
- Ian Rollo
- Content type: Review
- Open Access
- Published: 20 July 2021
- Pages: 2485 - 2495
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Grip strength performance from 9431 participants of the GenoFit study: normative data and associated factors
Authors (first, second and last of 7)
- Jedd Pratt
- Giuseppe De Vito
- Colin Boreham
- Content type: Original Article
- Open Access
- Published: 02 July 2021
- Pages: 2533 - 2546
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Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue
Authors (first, second and last of 12)
- Haihui Zhuang
- Sira Karvinen
- Petri Wiklund
- Content type: Original Article
- Open Access
- Published: 05 June 2021
- Pages: 2679 - 2691
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Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach
Authors (first, second and last of 8)
- Jessica Cegielski
- Daniel J. Wilkinson
- Philip J. Atherton
- Content type: Original Article
- Open Access
- Published: 27 May 2021
- Pages: 2653 - 2665
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Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline
Authors (first, second and last of 8)
- Carlos J. Padilla
- Markus E. Harrigan
- W. David Arnold
- Content type: Original Article
- Published: 24 April 2021
- Pages: 1265 - 1281
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Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice
Authors (first, second and last of 4)
- Jonathan D. Dorigatti
- Kevin M. Thyne
- Adam B. Salmon
- Content type: Original Article
- Published: 23 April 2021
- Pages: 1497 - 1511
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Lifelong exercise is associated with more homogeneous motor unit potential features across deep and superficial areas of vastus lateralis
Authors (first, second and last of 8)
- Eleanor J. Jones
- Jessica Piasecki
- Mathew Piasecki
- Content type: OriginalPaper
- Open Access
- Published: 24 March 2021
- Pages: 1555 - 1565
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Skeletal muscle mitochondrial DNA copy number and mitochondrial DNA deletion mutation frequency as predictors of physical performance in older men and women
Authors (first, second and last of 11)
- Allen Herbst
- Steven J. Prior
- Jonathan Wanagat
- Content type: Original Article
- Published: 19 March 2021
- Pages: 1253 - 1264
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Sex differences in the contribution of different physiological systems to physical function in older adults
Authors (first, second and last of 7)
- Siana Jones
- Martin G. Schultz
- Alun D. Hughes
- Content type: Original Article
- Open Access
- Published: 11 February 2021
- Pages: 443 - 455
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Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageing
Authors
- Andrew Wilhelmsen
- Kostas Tsintzas
- Simon W. Jones
- Content type: Original Article
- Open Access
- Published: 02 February 2021
- Pages: 85 - 110
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Associations of muscle lipid content with physical function and resistance training outcomes in older adults: altered responses with metformin
Authors (first, second and last of 9)
- Douglas E. Long
- Bailey D. Peck
- Rosicka G. Walton
- Content type: Original Article
- Published: 18 January 2021
- Pages: 629 - 644
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Effects of 16 months of high intensity resistance training on thigh muscle fat infiltration in elderly men with osteosarcopenia
Authors (first, second and last of 8)
- Mansour Ghasemikaram
- Oliver Chaudry
- Klaus Engelke
- Content type: Original Article
- Published: 15 January 2021
- Pages: 607 - 617
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Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study
Authors (first, second and last of 8)
- Angelo Di Iorio
- Roberto Paganelli
- Francesca Cecchi
- Content type: Original Article
- Open Access
- Published: 21 November 2020
- Pages: 1053 - 1064
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Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss
Authors (first, second and last of 6)
- Richard Kirwan
- Deaglan McCullough
- Claire Stewart
- Content type: Original Article
- Open Access
- Published: 01 October 2020
- Pages: 1547 - 1578
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Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults
Authors (first, second and last of 6)
- Henry J. Bonilla
- Maria L. Messi
- Osvaldo Delbono
- Content type: Original Article
- Published: 18 September 2020
- Pages: 1431 - 1443
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Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin
Authors (first, second and last of 16)
- Christopher A. Wolff
- Marcus M. Lawrence
- Benjamin F. Miller
- Content type: Original Article
- Published: 05 August 2020
- Pages: 809 - 828
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High-intensity exercise training induces mitonuclear imbalance and activates the mitochondrial unfolded protein response in the skeletal muscle of aged mice
Authors (first, second and last of 16)
- André Victor Cordeiro
- Guilherme Francisco Peruca
- Eduardo Rochete Ropelle
- Content type: Short Communication
- Published: 31 July 2020
- Pages: 1513 - 1518
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Regular endurance exercise of overloaded muscle of young and old male mice does not attenuate hypertrophy and improves fatigue resistance
Authors (first, second and last of 5)
- Paul William Hendrickse
- Raulas Krusnauskas
- Hans Degens
- Content type: Original Article
- Open Access
- Published: 08 July 2020
- Pages: 741 - 757
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Muscle from aged rats is resistant to mechanotherapy during atrophy and reloading
Authors (first, second and last of 11)
- Marcus M. Lawrence
- Douglas W. Van Pelt
- Esther E. Dupont-Versteegden
- Content type: ORIGINAL ARTICLE
- Published: 25 June 2020
- Pages: 65 - 83
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Poor mitochondrial health and systemic inflammation? Test of a classic hypothesis in the Baltimore Longitudinal Study of Aging
Authors (first, second and last of 7)
- Marta Zampino
- Nicholas A. Brennan
- Luigi Ferrucci
- Content type: Original Article
- Published: 22 June 2020
- Pages: 1175 - 1182
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Identification of biomarkers for physical frailty and sarcopenia through a new multi-marker approach: results from the BIOSPHERE study
Authors (first, second and last of 15)
- Riccardo Calvani
- Anna Picca
- Emanuele Marzetti
- Content type: Original Article
- Published: 01 June 2020
- Pages: 727 - 740
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Vaccination mitigates influenza-induced muscular declines in aged mice
Authors (first, second and last of 6)
- Spencer R. Keilich
- Erica C. Lorenzo
- Laura Haynes
- Content type: Original Article
- Published: 29 May 2020
- Pages: 1593 - 1608
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Superoxide-mediated oxidative stress accelerates skeletal muscle atrophy by synchronous activation of proteolytic systems
Authors (first, second and last of 11)
- Young C. Jang
- Karl Rodriguez
- Holly Van Remmen
- Content type: Original Article
- Published: 26 May 2020
- Pages: 1579 - 1591