Abstract
Zein was investigated in this study as a coating material for colon specific delivery of prednisolone. To strengthen the ability of film layer in the protection of a dosage form, Kollicoat® MAE 100P was investigated together with zein in an appropriate ratio. Interactions between these materials were evaluated by Fourier Transform Infrared spectroscopy (FTIR). Through the simulated gastrointestinal (GI) environment, the coated tablets released drug immediately after passing the intestinal medium. Zein was proved to be a potential coating material for a delayed release of drug to colon. FTIR spectra indicated that zein and Kollicoat® MAE 100P had only physical interactions at different ratios. Various parameters should be critically controlled in the preparation process to achieve the colon drug delivery. This work may contribute to new applications of zein for attempts of pharmaceutical scientists to design oral controlled drug release dosage forms.
Access provided by CONRICYT-eBooks. Download to read the full chapter text
Chapter PDF
Similar content being viewed by others
References
Philip AK, Philip B (2010) Colon targeted drug delivery systems: a review on primary and novel approaches. Oman med j 25:79
Akala EO, Elekwachi O, Chase V, Johnson H, Lazarre M, Scott K (2003) Organic redox-initiated polymerization process for the fabrication of hydrogels for colon-specific drug delivery. Drug Devel Ind Pharm 29:375–386
Rubinstein A (1995) Approaches and opportunities in colon-specific drug delivery. Crit Rev™ Ther Drug Carrier Syst 12
Yang L, Chu JS, Fix JA (2002) Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation. Int J Pharm 235:1–15
Muraoka M, Hu Z, Shimokawa T, Sekino S-I, Kurogoshi R-E, Kuboi Y et al (1998) Evaluation of intestinal pressure-controlled colon delivery capsule containing caffeine as a model drug in human volunteers. J Controlled Release 52:119–129
Philip AK, Pathak K, Shakya P (2008) Asymmetric membrane in membrane capsules: a means for achieving delayed and osmotic flow of cefadroxil. Eur J Pharm Biopharm 69:658–666
Tuleu C, Andrieux C, Cherbuy C, Darcy-Vrillon B, Duee P, Chaumeil J (2001) Colonic delivery of sodium butyrate via oral route: acrylic coating design of pellets and in vivo evaluation in rats. Methods Find Exp Clin Pharmacol 23:245–253
Akhgari A, Sadeghi F, Garekani HA (2006) Combination of time-dependent and pH-dependent polymethacrylates as a single coating formulation for colonic delivery of indomethacin pellets. Int j pharm 320:137–142
Kadam VD, Gattani SG (2010) Development of colon targeted multiparticulate pulsatile drug delivery system for treating nocturnal asthma. Drug delivery 17:343–351
Paliwal R, Palakurthi S (2014) Zein in controlled drug delivery and tissue engineering. J Controlled Release 189:108–122
Zelikin AN (2010) Drug releasing polymer thin films: new era of surface-mediated drug delivery. ACS nano 4:2494–2509
Macleod GS, Fell JT, Collett JH, Sharma HL, Smith A-M (1999) Selective drug delivery to the colon using pectin: chitosan: hydroxypropyl methylcellulose film coated tablets. Int j pharm 187:251–257
Acknowledgements
This research is partially funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 106-YS.05-2015.02. We also thank to International University and Vietnam National University—Ho Chi Minh City for supporting to our research activities.
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this paper
Cite this paper
Nguyen, M.NU., Vo Van, T., Tran, P.HL., Tran, TD. (2018). Development of a Zein-Based System for Colon Specific Delivery. In: Vo Van, T., Nguyen Le, T., Nguyen Duc, T. (eds) 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6) . BME 2017. IFMBE Proceedings, vol 63. Springer, Singapore. https://doi.org/10.1007/978-981-10-4361-1_85
Download citation
DOI: https://doi.org/10.1007/978-981-10-4361-1_85
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-4360-4
Online ISBN: 978-981-10-4361-1
eBook Packages: EngineeringEngineering (R0)