Abstract
Inflammation is a dynamic process of plasma-derived and cellular events occurring in response to tissue injury or infection. The early stages of acute inflammation are characterized by the sequential release of mediators including histamine, 5-hydroxytryptamine (5-HT), kinins, prostanoids, substance P and nitric oxide (NO). Prostaglandins (PGs) and thromboxanes (TXs), collectively termed prostanoids, are biologically active molecules operative in both acute and chronic inflammation. They are formed from membrane-released arachidonic acid by a series of enzymes including cyclooxygenase (COX), alternatively named prostaglandin H synthase (PGHS), or prostaglandin endoperoxidase synthase.
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References
Xie W, Chipman JG, Robertson DL, Erickson RL, Simmons DL. Expression of a mitogenresponsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA. 1991; 88: 2692–6.
Kujubu DA, Fletcher S, Varnum BC, Lim RW, Herschman HR. TIS 10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem. 1991; 266: 12866–72.
Appleton I, Tomlinson A, Colville-Nash PR, Willoughby DA. Temporal and spatial immunolocalization of cytokines in murine chronic granulomatous tissue. Lab Invest. 1993; 69: 405–14.
Edward JC, Sedgwick AD, Willoughby DA. The formation of a structure with the features of a synovial lining by subcutaneous injection of air: an in vivo tissue culture system. J Pathol. 1981; 134: 147–56.
Vane JR, Mitchell JA, Appleton I et al. Inducible isoforms of cyclooxygenase and nitric oxide synthase in inflammation. Proc Natl Acad Sci USA. 1994; 91: 2046–50.
Appleton I, Tomlinson A, Mitchell JA, Willoughby DA. Distributions of cyclooxygenase isoforms in murine chronic granulomatous inflammation. Implications for future anti-inflammatory therapy. J Pathol. 1995; 176: 413–20.
O’Banion MK, Winn VD, Young DA. cDNA cloning and functional activity of a glucocorticoid regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA. 1992; 89: 4888–92.
Hla T, Nielson K. Human cyclooxygenase 2 cDNA. Proc Nat ! Acad Sci USA. 1992; 89: 7384–8.
Rzymkiewicz D, Leinang K, Baird N, Morrison AR. Regulation of prostaglandin endoperoxide synthase gene expression in rat mesangial cells by interleukin-1ß. Am J Physiol. 1994; 266: F39–45.
O’Banion MK, Dusel JC, Chang JW, Coleman PD. Cytokine induction of prostaglandin G/H synthase 2 (PGHS 2) and inducible nitric oxide synthase (iNOS) in primary murine glial cell cultures. 9th Int Conf Prostaglandins, Italy, 1994.
Herschmann HR, Gilbert RS, Xie W, Luner S, Reddy S. Regulation and role of TIS I0/PGS2. Adv Prost Thromb Leuk Res. 1995; 23: 23–8.
Kester M, Coroneos E, Thomas PJ, Dunn MJ. Endothelin stimulates prostaglandin endoperoxide synthase 2 mRNA expression and protein synthesis through a tyrosine signalling pathway in rat mesangial cells. J Biol Chem. 1994; 269: 22574–80.
Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev. 1991; 43: 109–42.
Stefanovic-Racic M, Stadler J, Evans CH. Nitric oxide and arthritis. Arthritis Rheum. 1993; 36: 1036–44.
Jansen A, Cook T, Taylor GM et al. Induction of nitric oxide synthase in rat immune complex glomerulonephritis. Kidney Int. 1994; 45: 1215–9.
Boughton-Smith NK, Evans SM, Hawkey CJ et al. Nitric oxide synthase activity in ulcerative colitis and Crohn’s disease. Lancet. 1993; 342: 338–40.
Lin RF, Lin TS, Tilton RG, Cross AH. Nitric oxide localised to the spinal cords of mice with an experimental allergic encephalomyelitis: an electron paramagnetic resonance study. J Exp Med. 1993; 178: 643–8.
Nathan C, Hibbs JB Jr. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol. 1991; 3: 65–70.
Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite oxidation of sulthydryls: The cytotoxic potential of superoxide and nitric oxide. J Biol Chem. 1991; 266: 4244–50.
Sautebin L, Di Rosa M. Nitric oxide modulates prostacyclin biosynthesis in the lung of endotoxin-treated rats. Eur J Pharmacol. 1994; 262: 193–6.
Salvemini D, Seibert K, Masferrer JL, Misko TP, Currie MG, Needleman P. Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. J Clin Invest. 1994; 93: 1940–7.
Habib A, Bernard C, Tedgui A, Maclouf J. Evidence of cross talk between inducible nitric oxide synthase and cyclooxygenase 2 in rat peritoneal macrophages. 9th Int Conf Prostaglandins, Italy. 1994.
Swierkosz TA, Mitchell JA, Warner TD, Botting RM, Vane JR. Co-induction of nitric oxide synthase and cyclooxygenase: interactions between nitric oxide and prostanoids. Br J Pharmacol. 1995; 114: 1335–42.
Tetsuka T, Daphna-Iken D, Srivastava SK, Baier LD, DuMaine J, Morrison AR. Cross talk between cyclooxygenase and nitric oxide pathways: Prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin-1. Proc Natl Acad Sci USA. 1994; 91: 12168–72.
Marotta P, Sautebin L, DiRosa M. Modulation of the induction of nitric oxide synthase by eicosanoids in the murine macrophage cell line J774. Br J Pharmacol. 1992;107:640- I.
Gaillard T, Mulsch A, Klein H, Decker K. Regulation of prostaglandin E2 of cytokine elicited nitric oxide synthesis in rat liver macrophages. J Biol Chem. 1992; 373: 897–902.
Wahl SM, Allen JB, Costa GL, Wong HL, Dasch JR. Reversal of acute and chronic synovial inflammation by anti-transforming growth factor P. J Exp Med. 1993; 177: 225–30.
Fujii E, Irie K, Muraki T. Nitric oxide (NO) plays a role of increase in vascular permeability induced by bradykinin, substance P and 5-HT, but not by PAF and histamine in mouse skin. Can J Physiol Pharmacol. 1994; 72 (S1): 470.
Velo GP, Dunn CJ, Giroud JP, Timsit J, Willoughby DA. Distribution of prostaglandins in inflammatory exudate. J Pathol. 1973; 111: 149–58.
Tomlinson A, Appleton I, Moore AR et al. Cyclooxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy. Br J Pharmacol. 1994; 113: 693–8.
Yamamoto S, Dunn CJ, Deporter DA, Capasso F, Willoughby DA, Huskisson EC. A model for the quantitative study of Arthus (immunologic) hypersensitivity in rats. Agents Actions. 1975; 5: 374–7.
Moore AR, Willis D, Gilroy D, Tomlinson A, Appleton I, Willoughby DA. Cyclooxygenase in rat pleural hypersensitivity reactions. Adv Prost Thromb Leuk Res. 1995; 23: 349–51.
Roper RL, Phipps RP. Prostaglandin E2 regulation of the immune response. Adv Prost Thromb Leuk Res. 1994; 22: 101–11.
Maines MD. Herne oxygenase: function, multiplicity, regulatory mechanisms and clinical application. FASEB J. 1988; 2: 2557–68.
Nath KA, Balla G, Vercellotti GM et al. Induction of heme oxygenase is a rapid protective response in rhabdomyolysis in the rat. J Clin Invest. 1992; 90: 267–70.
Nakagami T, Toyomura K, Kinoshita T, Morisawa S. A beneficial role of bile pigments as an endogenous tissue protector: anticomplement effects of biliverdin and conjugated bilirubin. Biochim Biophys Acta. 1993; 1158: 189–93.
Maines MD, Trakshel GM, Kutty RK. Characterization of two constitutive forms of rat liver microsomal heme oxygenase: only one molecular species of the enzyme is inducible. J Biol Chem. 1986; 251: 411–9.
Willis D. Expression and modulatory effects of heme oxygenase in acute inflammation in the rat. Inflam Res. 1995; 44: S218–20.
Weiss G, Werner-Felmayer G, Werner ER, Grunewald K, Wachter H, Hemtze MW. Iron regulates nitric oxide synthase activity by controlling nuclear transcription. J Exp Med. 1994; 180: 969–76.
White KA, Marietta MA. Nitric oxide synthase is a cytochrome P450 type hemoprotein. Biochemistry. 1992;31:6627–3 I .
Albina JE, Cui S, Mateo RB, Reichner JS. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J Immunol. 1993; 150: 5080–5.
Lu X, Xie W, Reed D, Bradshaw WS, Simmons DL. Non steroidal anti-inflammatory drugs cause apoptosis and induce cyclooxygenases in chick embryo fibroblasts. Proc Natl Acad Sci USA. 1995; 92: 7961–5.
Henry Y, Lepoivre M, Drapier JC, Ducrocq C, Boucher JL, Guissani A. EPR characterization of molecular targets for NO in mammalian cells and organelles. FASEB J. 1993; 7: 1124–34.
Willis D, Tomlinson A, Frederick R, Paul-Clark MJ, Willoughby DA. Modulation of heme oxygenase activity in rat brain and spleen by inhibitors and donors of nitric oxide. Biochem Biophys Res Commun. 1995; 214: 1152–6.
Tetsuka T, Daphna-Iken D, Srivastava SK, Morrison AB. Regulation of heme oxygenase mRNA in mesangial cells: prostaglandin E2 negatively modulates IL-1 induced heme oxygenase-1 mRNA. Biochem Biophys Res Commun. 1995; 212: 617–23.
Santoro MG, Garaci E, Amici C. Induction of heat shock protein synthesis by prostaglandins with antineoplastic and antiviral activity. Adv Prost Thromb Leuk Res. 1990; 21: 867–74.
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Willoughby, D.A., Tomlinson, A., Gilroy, D., Willis, D. (1996). Inducible enzymes with special reference to COX-2 in inflammation and apoptosis. In: Vane, J., Botting, J., Botting, R. (eds) Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9029-2_4
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DOI: https://doi.org/10.1007/978-94-010-9029-2_4
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-9031-5
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