Abstract
Research on arterial chemoreceptors, particularly on the carotid body, has been fruitful in the last fifty years, to which this review is addressed. The functional anatomy of the organ appears to be well established. The biophysical bases by which glomus cells transduce chemical changes in the milieu intérieur (hypoxia, hypercapnia, acidosis) into electrical and biochemical changes in glomus cells have received much attention. Physical changes (in temperature, flow and osmolarity) are also detected by the carotid body. Electrical coupling between glomus cells themselves appears as very extensive. Sustentacular cells classically considered as ensheathing glia for glomus cells and nerve endings now appear to behave as stem cells precursors for glomus cells under chronic hypoxic conditions. Many papers have been devoted to transmitters released from glomus cells (acetylcholine, dopamine, ATP) and well as to their effects upon chemosensory nerve activity. Chemosensory neurons have been explored from generation of action potentials at peripheral nerve endings, passing to properties of perikarya at petrosal ganglia and finally at characterization of synaptic transmission at solitary tract nuclei. There is abundant literature on ventilatory and cardiovascular reflexes elicited from arterial chemoreceptors. The transient effects of sudden and brief withdrawal of chemosensory discharges by hyperoxia also provide clues on the role played by carotid bodies in the homeostasis of full organisms.
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Alcayaga J, Iturriaga R, Varas R, Arroyo J, Zapata P (1998) Selective activation of carotid nerve fibres by acetylcholine applied to the cat petrosal ganglion in vitro. Brain Res 786: 47–54
Biscoe TJ, Duchen MR (1990) Responses of type I cells dissociated from the rabbit carotid body to hypoxia. J Physiol 428: 39–59
Buerk DG, Lahiri S, Chugh D, Mokashi A (1995) Electrochemical detection of rapid DA release kinetics during hypoxia in perfused-superfused cat CB. J Appl Physiol 78: 830–7
Campanucci VA, Nurse CA (2007) Autonomic innervation of the carotid body: Role in efferent inhibition. Respir Physiol Neurobiol 157: 83–92
Conde SV, Monteiro EC (2006) Profiles for ATP and adenosine release at the carotid body in response to O2 concentrations. Adv Exp Med Biol 580: 179–84
Dejours P (1957) Methodological importance of the study of a living organism at the initial phase of interruption of a physiological equilibrium. C R Hebd Seances Acad Sci 245: 1946–8
Donnelly DF (1993) Electrochemical detection of catecholamine release from rat carotid body in vitro. J Appl Physiol 74: 2330–7
Eyzaguirre C (2007) Electric synapses in the carotid body-nerve complex. Respir Physiol Neurobiol 157: 116–122
Eyzaguirre C, Fitzgerald RS, Lahiri S, Zapata P (1983) Arterial chemoreceptors. In: American Physiological Society: Handbook of Physiology, sect. 2: The Cardiovascular System, vol. 3: Peripheral Circulation and Organ Blood Flow. Baltimore, MD: Williams & Wilkins, pp. 557–621
Eyzaguirre C, Koyano H (1965) Effects of hypoxia, hypercapnia, and pH on the chemoreceptor activity of the carotid body in vitro. J Physiol 178: 385–409
Eyzaguirre C, Koyano H, Taylor JR (1965) Presence of acetylcholine and transmitter release from carotid body chemoreceptors. J Physiol 178: 463–76
Eyzaguirre C, Monti-Bloch L, Baron M, Hayashida Y, Woodbury JW (1989) Changes in glomus cell membrane properties in response to stimulants and depressants of carotid nerve discharge. Brain Res 477: 265–279
Fidone S, González C, Yoshizaki K (1982) Effects of low oxygen on the release of dopamine from the rabbit carotid body in vitro. J Physiol 333: 93–110
Fitzgerald RS, Lahiri S (1986) Reflex responses to chemoreceptor stimulation. In: American Physiological Society (eds) Handbook of Physiology, sect. 3, vol. 2, pp. 313–362
Fitzgerald RS, Shirahata M (1994) Acetylcholine and carotid body excitation during hypoxia in the cat. J Appl Physiol 76: 1566–1574
Fitzgerald RS, Shirahata M (1997) Systemic responses elicited by stimulating the carotid body: primary and secondary mechanisms. In: González C (ed) The Carotid Body Chemoreceptors. Berlin: Springer-Verlag, pp. 171–191
Fitzgerald RS, Shirahata M, Wang HY (2000) Acetylcholine is released from in vitro cat carotid bodies during hypoxic stimulation. Adv Exp Med Biol 475: 485–94
González C, Almaraz L, Obeso A, Rigual R (1994) Carotid body chemoreceptors: From natural stimuli to sensory discharges. Physiol Rev 74: 829–898
Honda Y, Watanabe S, Hashizume I, Satomura Y, Hata N, Sakakibara Y, Severinghaus JW (1979) Hypoxic chemosensitivity in asthmatic patients two decades after carotid body resection. J Appl Physiol 46: 632–8
Iturriaga R, Alcayaga J, Zapata P (1996) Dissociation of hypoxia-induced chemosensory responses and catecholamine efflux in cat carotid body superfused in vitro. J Physiol 497: 551–64
López-Barneo J, López-López JR, Ureña J, González C (1988) Chemotransduction in the carotid body: K+ current modulated by PO2 in type I chemoreceptor cells. Science 241: 580–582
McDonald DM (1981) Peripheral chemoreceptors: structure-function relationships of the carotid body. In: Hornbein TF (ed) Regulation of Breathing. Lung Biology in Health and Disease, vol 17. NY: Marcel Dekker. pp. 105–319
McQueen DS, Bond SM, Moores C, Chessell I, Humphrey PP, Dowd E (1998) Activation of P2X receptors for adenosine triphosphate evokes cardiorespiratory reflexes in anaesthetized rats. J Physiol 507: 84–55
Mulligan E, Lahiri S (1981) Dependence of carotid chemoreceptor stimulation by metabolic agents on PaO2 and PaCO2. J Appl Physiol 50: 884–891
Nurse CA, Zhang M (2001) Synaptic mechanisms during re-innervation of rat arterial chemoreceptors in co-culture. Comp Biochem Physiol A - Mol Integr Physiol 130: 241–251
O’Regan RG (1979) Responses of the chemoreceptors of the cat carotid body perfused with cell-free solutions. Ir J Med Sci 148: 78–85
Pardal R, Ortega-Sáenz P, Durán R, López-Barneo J (2007) Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body. Cell 131: 364–377
Peers C, Buckler KJ (1995) Transduction of chemostimuli by the type I carotid body cell. J Memb Biol 144: 1–9
Prasad M, Fearon IM, Zhang M, Laing M, Vollmer C, Nurse CA (2001) Expression of P2X2 and P2X3 receptor subunits in rat carotid body afferent neurones: role in chemosensory signalling. J Physiol 537: 667–77
Rodman JR, Curran AK, Henderson KS, Dempsey JA, Smith CA (2001) Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia. J Appl Physiol 91: 328–35. Erratum in: J Appl Physiol 91(5): following table of contents
Rong W, Gourine AV, Cockayne DA, Xiang Z, Ford APDW, Spyer KM, Burnstock G (2003) Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci 23: 11315–11321.
Schultz HD, Li YL, Ding Y (2007) Arterial chemoreceptors and sympathetic nerve activity: implications for hypertension and heart failure. Hypertension 50: 6–13
Shirahata M, Fitzgerald RS (1996) Release of acetylcholine from cultured cat and pig glomus cells. Adv Exp Med Biol 410: 233–237
Verna A (1997) The mammalian carotid body: morphological data. In: González C (ed) The Carotid Body Chemoreceptors. Berlin: Springer; Austin, TX: Landes, pp. 1–29
Zapata P (1997) Chemosensory activity in the carotid nerve: Effects of pharmacological agents. In: González C (ed) The Carotid Body Chemoreceptors. Berlin: Springer-Verlag, pp. 119–146
Zapata P (2007) Is ATP a suitable co-transmitter in carotid body arterial chemoreceptors? Respir Physiol Neurobiol 157: 106–115
Zhang M, Zhong HJ, Vollmer C, Nurse CA (2000) Co-release of ATP and ACh mediates hypoxic signalling at rat carotid body chemoreceptors. J Physiol, Lond 525: 143–158
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Fitzgerald, R., Eyzaguirre, C., Zapata, P. (2009). Fifty Years of Progress in Carotid Body Physiology – Invited Article . In: Gonzalez, C., Nurse, C.A., Peers, C. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 648. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2259-2_2
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