Abstract
Radiologic assessment is important for the diagnosis of vascular malformations. MR is the best modality to evaluate the extent of the lesions and the relation with the adjacent structures. Low-flow malformations can be differentiated from high-flow lesions using the characteristics of the signal on different sequences. Routine sequences are T1- and T2-weighted SE images with fat suppression and/or STIR and post-contrast T1-weighted images. On spin-echo sequences, the vessels in the high-flow malformations appear as a signal void, and on gradient echo, the vessels are bright. 3D gradient-echo acquisitions gadolinium-enhanced and non-contrast imaging angiography using time-of-flight and true fast imaging with steady-state precession (TrueFISP) are useful to specify the type and the extension of the vascular malformation. More recently, time-resolved imaging with a high temporal resolution allows for a dynamic analysis of the vascular malformation and is particularly useful to identify the arterial feeders of a high-flow malformation. CT is useful to assess bone destruction and calcifications and also for three-dimensional reformation.
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MRI
MRI is the best method to evaluate the extension of the malformation and its relationship with adjacent structures [1]. The MR exam evaluates the extension; the size of the malformation; the infiltration of muscles, bones, tendons, and articulations; and the location of nerves, vessels, arteries, veins, and lymphatics included in the vascular malformations . MRI is also helpful in evaluating responses to treatment [2].
Routine sequences should include T1-weighted spin-echo or fast SE sequences, T2-weighted fat-suppressed fast SE acquisitions, and T1-weighted post-contrast fat-suppressed sequences. Depending on the clinical context and the result of Doppler US imaging, specific sequences are recommended depending whether we are investigating a slow- or fast-flow malformation .
Regarding slow-flow malformations , T1-weighted spin-echo sequences and T2-weighted fat suppression with short TI (inversion time) inversion recovery (STIR) are useful to determine the extent of the venous or lymphatic malformations. A T1-weighted spin-echo acquisition with fat suppression after gadolinium injection is required to document the enhancement of the malformation and differentiate venous malformation that will enhance from lymphatic malformation displaying minimal enhancement on the septa. 3D ultrafast spoiled gradient-echo acquisitions are also useful to evaluate the enhancement of the malformation after gadolinium injection. They can be repeated at different time frame to document the pattern of enhancement [3].
3D gadolinium-enhanced fat gradient-echo acquisition is helpful to evaluate the vascularization of the malformation [4]. To evaluate the dynamic circulation of the vascular anomalies, time-resolved MR angiography sequences are used and allow to differentiate the arterial inflow and venous drainage [5, 6].
CT Scan
Computed tomography plays a limited role for the evaluation of vascular anomalies given the inherent lack of soft tissue details and the advance of MR imaging. However, CT scan is useful for the evaluation of bone erosion and phleboliths, although last generation of multidetector CT can be used to obtain a three-dimensional reformation of vessels and to plan the embolization in cases of complex vascular anomalies. They are also useful to document aneurysm formation in high-flow malformations.
Venous Malformations
Different patterns of venous malformations (VMs) can be observed. The most common is a cavitary lesion with a delayed enhancement with or without abnormal draining vein. The second pattern is the presence of dysplastic veins that can be localized or diffuse in particular in upper or lower limbs. These patterns are better differentiated with percutaneous phlebography of the lesion before sclerotherapy.
Also, VMs can be a component of many syndromes, such as Klippel-Trénaunay, blue rubber bleb nevus, Maffucci’s, Proteus, Cloves, or Bannayan-Riley-Ruvalcaba syndromes.
On CT scan, venous malformation shows a hypodense or heterogeneous lesion before contrast which enhances peripherally and slowly after injection of contrast. Phleboliths, bone erosion, or bony overgrowth is more clearly depicted on CT scan images (Fig. 27.1).
MRI – The first acquisition has to be done with a wide field of view to assess the extent of the lesion. VM can be seen on every part of the body. On T1-weighted images, VM is hypointense or isointense compared to the muscle. They may present with a heterogeneous or intermediate signal secondary to thrombosis or hemorrhage. Absence of flow void is mandatory for the diagnosis of VM. On fat-sat T2-weighted sequences, high-signal intensity is observed. Sometimes, low-signal intensity is related to thrombosis or phleboliths. Fat suppression with short TI (inversion time) inversion recovery (STIR) T2-weighted sequence with a 512 matrix is well suited for this purpose. T2-weighted gradient-echo sequences can also be used to demonstrate calcifications or hemosiderin. On gradient-echo sequences, the absence of signal in the blood vessel in the vicinity of the malformation suggests a slow-flow malformation. Fluid-fluid level can be seen in regions of low or no flow.
FSE T1-weighted sequences with fat suppression should be performed after gadolinium injection to evaluate the perfusion of the malformation. Heterogeneous enhancement is seen after injection of gadolinium. MRI may also demonstrate soft tissue changes related to the VM, such as fatty replacement, atrophy of the adjacent musculature, or hypertrophy of the subcutaneous fat compared with the contralateral side [7].
To evaluate the dynamics of the VM, we perform a dynamic perfusion study 1, 2, 5, and 10 min after contrast infusion using a 3D ultrafast spoiled gradient-echo acquisition (volumetric interpolated breath-hold examination (VIBE) sequence). These contrast-enhanced 3D acquisitions are also useful to appreciate the drainage of the malformation in the venous system [1, 8].
On 3D contrast-enhanced MRA, the lesions and their drainage into the systemic venous system can be mapped and should be documented on the report. The absence of deep venous system can be a contraindication for sclerosing treatment in some complex cases (Figs. 27.2, 27.3, and 27.4).
Arteriovenous Malformations
Arteriovenous malformations (AVMs) are isolated anomalies or are part of a syndrome, such as Parkes Weber or Rendu-Osler-Weber.
On CT scan, AVMs appear as highly enhancing lesions with numerous feeding and draining vessels, without persistent tissue staining (Fig. 27.5).
MRI shows arteries and veins with low-signal intensity due to the flow void phenomenon of rapid and/or turbulent blood flow on both T1- and T2-weighted spin-echo sequences. Except for the presence of fat occasionally, no soft tissue mass is visible. A hypersignal is observed on gradient-echo and angiographic sequences. Occasionally, there are numerous interspersed small punctuated areas of high-signal intensity caused by hemorrhage and thrombosis. Gadolinium-enhanced MR angiography is helpful to evaluate feeding arteries and draining veins. The presence of an early venous filling is typically seen in AVMs. Using time-resolved MR angiography sequences, it is now possible to evaluate the dynamic opacification of AVM with the arterial feeders, nidus, and draining veins [6, 9, 10]. Since these sequences have a high temporal resolution, there is a compromise on spatial resolution which is lower than conventional 3D MR angiography using parallel imaging techniques (Fig. 27.6). In this setting, it can be useful to perform a 3D gradient-echo acquisition at high resolution during the steady-state phase of contrast enhancement to have a good delineation of the extension of the malformation.
Capillary Malformations
Capillary malformations are superficial vascular malformations. The only indication for MR imaging is to rule out an underlying AVM or associated complex anomalies such as Sturge-Weber, Klippel-Trénaunay, Parkes Weber, Cobb, or Proteus syndromes.
MRI – Capillary malformations are hyperintense on fluid-sensitive sequences and hypointense on T1-weighted images and display enhancement after contrast administration.
Lymphatic Malformations
Lymphatic malformations are divided into two types: macrocystic or microcystic. We will not discuss the lymphedema or complex syndrome associated with lymphatic malformations (Fig. 27.7).
CT scan of macrocystic lymphatic malformations shows a low-attenuation mass with enhancement of the septa after contrast injection [11].
A pure microcystic lymphangioma is ill defined with fat infiltration and no enhancement after contrast injection is observed.
MRI shows a septated mass with low-signal intensity on T1 and high-signal intensity on T2. Because of varying amounts of protein or hemorrhage within the lesion, lymphatic malformations occasionally present with variable-signal intensity on T1 and T2 sequences. Sometimes, a high signal on T1 sequence or a fluid level can be observed in cases of cyst with a high content of protein or a hemorrhagic content [3]. No gadolinium enhancement is visible, except in the septa. Pure microcystic lymphatic malformations are isointense on T1 and display a heterogeneous signal on T2, with or without a slight heterogeneous enhancement on T1 post gadolinium. Stranding of the adjacent subcutaneous fat may be present.
Bone lesions can be seen on T2-weighted sequences secondary to osteolysis, as seen in Gorham-Stout syndrome, also known as disappearing bone disease [12].
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Dubois, J., Soulez, G. (2015). Role of MR and CT in Diagnostics. In: Mattassi, R., Loose, D., Vaghi, M. (eds) Hemangiomas and Vascular Malformations. Springer, Milano. https://doi.org/10.1007/978-88-470-5673-2_27
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DOI: https://doi.org/10.1007/978-88-470-5673-2_27
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