Abstract
Krüppel-like factors (KLFs) are members of an emerging family of DNA-binding transcriptional regulators with critical roles in development, differentiation, and a number of other key cellular processes. The KLF family contains at least 17 members, many with overlapping patterns of expression and function, and all linked by a similar DNA-binding element. During development, KLFs may function as transcriptional activators or repressors depending on the cell or tissue context or even the stage of development. Here, we provide a brief introduction to the expression patterns and established roles of the KLFs in development. By examining these patterns and functions, we uncover a number of themes that are explored in detail in ensuing chapters.
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Yang, Y., Katz, J.P. (2009). Developmental Expression of Krüppel-like Factors. In: Nagai, R., Friedman, S.L., Kasuga, M. (eds) The Biology of Krüppel-like Factors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-87775-2_5
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