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Interaktion von disseminierten Tumorzellen mit Stamm- und Immunzellen im prämetastatischen Knochenmarkmilieu

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Knochenmetastasen

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Zusammenfassung

Hämatopoetische Stammzellen (HSC) sind im Knochenmark in einem hoch spezialisierten Mikromilieu, der sog. Nische, lokalisiert. Diese setzt sich aus zellulären Bestandteilen, wie z. B. mesenchymalen Stromazellen (MSC), Osteoblasten und Endothelzellen, sowie extrazellulärer Matrix und löslichen Faktoren zusammen. Auch für disseminierte Tumorzellen stellt die Nische eine attraktive Umgebung dar, um sich therapeutischen Ansätzen zu entziehen, zu proliferieren oder auch in einen Ruhezustand zu verfallen. Für diese Prozesse sind molekulare Interaktionen zwischen Tumorzellen und den Stamm- und Vorläuferzellen im Knochenmark von Bedeutung, die u. a. durch Integrine oder Chemokine wie stromal-derived factor-1 (SDF-1) vermittelt werden. Auch verschiedene Immunzellen können eine den Tumor unterstützenden Wirkung haben. Die Konkurrenz zwischen Tumorzellen und HSC in der Nische resultiert teilweise in der Verdrängung unreifer Vorläuferzellen in das periphere Blut der Patienten.

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Authors and Affiliations

  1. Medizinische Klinik und Poliklinik 1, Universitätsklinikum Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland

    Manja Wobus & Martin Bornhäuser

Authors
  1. Manja Wobus
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  2. Martin Bornhäuser
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Correspondence to Manja Wobus .

Editor information

Editors and Affiliations

  1. Universitätsklinik für Urologie, Universitätsklinikum Tübingen, Tübingen, Germany

    Arnulf Stenzl

  2. Universitätsfrauenklinik Düsseldorf, Düsseldorf, Germany

    Tanja Fehm

  3. Medizinische Klinik III, Bereich Endokrinologie, Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Germany

    Lorenz C. Hofbauer

  4. Orthopädisches Zentrum für Muskuloskelettale Forschung, Universität Würzburg, Würzburg, Germany

    Franz Jakob

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Wobus, M., Bornhäuser, M. (2014). Interaktion von disseminierten Tumorzellen mit Stamm- und Immunzellen im prämetastatischen Knochenmarkmilieu. In: Stenzl, A., Fehm, T., Hofbauer, L., Jakob, F. (eds) Knochenmetastasen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43471-0_1

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  • DOI: https://doi.org/10.1007/978-3-662-43471-0_1

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  • Print ISBN: 978-3-662-43470-3

  • Online ISBN: 978-3-662-43471-0

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