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The Genus Legionella

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The Prokaryotes

Abstract

Descriptions of newly recognized infectious diseases of man and the subsequent isolations and characterizations of the etiological agents have—during the past few decades—been confined largely to diseases caused by viruses. The list of newly described arboviruses grows annually and almost logarithmically; interspersed are other newly isolated and described mammalian viruses and their diseases. However, the discovery nowadays of a previously undescribed bacterium responsible for disease in man, highlighted by the isolation and fairly complete characterization of the etiological agent, is an infrequent occurrence. In fact, no descriptions of isolations of new families of bacterial pathogens of man have been published in the scientific literature available to us within the 25 or more years prior to 1977.

Use of trade names is for identification only and does not constitute endorsement by the Public Health Service or by the U.S. Department of Health and Human Services.

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Literature Cited

  • Beaty, H. N., Miller, A. A., Broome, C. V., Goings, S., Phillips, C. A. 1978. Legionnaires’ disease in Vermont, May to October 1977. Journal of the American Medical Association 240:127–131.

    Article  PubMed  CAS  Google Scholar 

  • Berdal, B. P., Farshy, C. E., Feeley, J. C. 1979. Detection of Legionella pneumophila antigen in urine by enzyme-linked immunospecific assay. Journal of Clinical Microbiology 9:575–578.

    PubMed  CAS  Google Scholar 

  • Blackmon, J. A., Hicklin, M. D., Chandler, F. W. 1978. Legionnaires’ disease: Pathologic and historical aspects of a “new” disease. Archives of Pathology and Laboratory Medicine 102:337–343.

    PubMed  CAS  Google Scholar 

  • Bozeman, F. M., Humphries, J. W., Campbell, J. M. 1968. A new group of rickettsia-like agents recovered from guinea pigs. Acta Virologica (Praha) 12:87–93.

    CAS  Google Scholar 

  • Brenner, D. J., Steigerwalt, A. G., Gorman, G. W., Weaver, R. E., Feeley, J. C., Cordes, L. G., Wilkinson, H. W., Patton, C., Thomason, B. W., Lewallen Sasseville, K. R. 1980. Legionella bozemanii sp. nov. and Legionella dumoffii sp. nov: Classification of two additional species of Legionella associated with human pneumonia. Current Microbiology 4:115–120.

    Google Scholar 

  • Brenner, D. J., Steigerwalt, A. G., McDade, J. E. 1979. Classification of the Legionnaires’ disease bacterium: Legionella pneumophila genus novum, species nova, of the family Legionellaceae, familia nova. Annals of Internal Medicine 90:656–658.

    Article  PubMed  CAS  Google Scholar 

  • Brenner, D. J., Steigerwalt, A. G., Weaver, R. E., McDade, J. E., Feeley, J. C., Mandel, M. 1978. Classification of the Legionnaires’ disease bacterium: An interim report. Current Microbiology 1:71–75.

    Article  Google Scholar 

  • Broome, C. V., Cherry, W. B., Winn, W. C., MacPherson, B. R., Jr. 1979. Rapid diagnosis of Legionnaires’ disease by direct immunofluorescent staining. Annals of Internal Medicine 90:1–4.

    Article  PubMed  CAS  Google Scholar 

  • Center for Disease Control. 1977. Morbidity and Mortality Weekly Report 26:93.

    Google Scholar 

  • Center for Disease Control. 1978a. In: Jones, G. L., Herbert, G. A. (eds.), “Legionnaires’“: The disease, the bacterium and methodology, pp. 155–161. Atlanta: Center for Disease Control.

    Google Scholar 

  • Center for Disease Control. 1978b. Legionnaires’ disease: Diagnosis and management. Annals of Internal Medicine 88:363–365.

    Article  Google Scholar 

  • Chandler, F. W., Hicklin, M. D., Blackmon, J. A. 1977. Demonstration of the agent of Legionnaires’ disease in tissue. New England Journal of Medicine 297:1218–1220.

    Article  PubMed  CAS  Google Scholar 

  • Cherry, W. B., Harris, P. P., Herbert, G. A., Thomason, B. M., McKinney, R. M. 1978b. Legionnaires’ disease—the disease and the bacterium with special reference to the laboratory diagnosis, pp. 163–174. In: Knapp, W., Holubar, K., Wick, G. (eds.) Immunofluorescence and related staining techniques. Amsterdam: Elsevier/North-Holland Biomedical Press.

    Google Scholar 

  • Cherry, W. B., McKinney, R. M. 1978. Detection in clinical specimens by direct immunofluorescence, pp. 129–146. In: Jones, G. L., Hebert, G. A., (eds.), “Legionnaires’“: The disease, the bacterium and methodology. Atlanta: Center for Disease Control.

    Google Scholar 

  • Cherry, W. B., Pittman, B., Harris, P. P., Hebert, G. A., Thomason, B. M., Thacker, L., Weaver, R. E. 1978a. Detection of Legionnaires ‘ disease bacteria by direct immunofluorescent staining. Journal of Clinical Microbiology 8:329–338.

    PubMed  CAS  Google Scholar 

  • Cordes, L. G., Wilkinson, H. W., Gorman, G. W., Fikes, B. J., Fraser, D. W. 1979. Atypical Legionella-like organism: Fastidious water-associated bacteria pathogenic for man. Lancet ii:927–930.

    Article  Google Scholar 

  • Dumoff, M. 1979. Direct in vitro isolation of the Legionnaires’ disease bacterium in two fatal cases. Cultural and staining characteristics. Annals of Internal Medicine 90:694–696.

    Article  PubMed  CAS  Google Scholar 

  • Edelstein, P. H., Finegold, S. M. 1979. Isolation of Legionella pneumophila from a transtracheal aspirate. Journal of Clinical Microbiology 9:457–458.

    PubMed  CAS  Google Scholar 

  • Edelstein, P. H., Meyer, R. D., Finegold, S. M. 1979a. Isolation of Legionella pneumophila from blood. Lancet i:750–751.

    Article  Google Scholar 

  • Edelstein, P. H., Meyer, R. D., Finegold, S. M. 1979b. Isolation of Legionella pneumophila from contaminated lung specimens. Journal of Clinical Microbiology 10:141–143.

    PubMed  CAS  Google Scholar 

  • Edelstein, P. H., Meyer, R. D., Finegold, S. M. 1980. Laboratory diagnosis of Legionnaires’ disease. American Review of Respiratory Disease 121:317–327.

    PubMed  CAS  Google Scholar 

  • Edelstein, P. H., McKinney, R. M., Meyer, R. D., Edelstein, M. A. C., Krause, C. J., Finegold, S. M. 1980. Immunologic diagnosis of Legionnaires’ disease: Cross-reactions with anaerobic and microaerophilic organisms and infectious caused by them. Journal of Infectious Diseases 141:652–655.

    Article  PubMed  CAS  Google Scholar 

  • England, A. C., McKinney, R. M., Skaliy, P., Gorman, G. W. 1980. A fifth serogroup of Legionella pneumophila. Annals of Internal Medicine 93:58–59.

    Article  PubMed  Google Scholar 

  • Farshy, C. E., Cruce, D. D., Klein, G. C., Wilkinson, H. M., Feeley, J. C. 1979. Immunoglobulin specificity of the micro-agglutination test for the Legionnaires’ disease bacterium. Annals of Internal Medicine 90:690.

    Article  PubMed  CAS  Google Scholar 

  • Farshy, C. E., Feeley, J. C. 1979. ELISA for Legionnaires’ disease—antibody and antigen detection systems, pp. 124–129. In: Jones, G. L., Hebert, G. A. (eds.), “Legionnaires’“: The disease, the bacterium and methodology. Atlanta: Center for Disease Control.

    Google Scholar 

  • Farshy, C. E., Klein, G. C., Feeley, J. C. 1978a. Detection of antibodies to the Legionnaires disease organism by micro-agglutination and micro-enzyme-linked immunosorbent assay tests. Journal of Clinical Microbiology 7:327–331.

    PubMed  CAS  Google Scholar 

  • Farshy, C. E., Klein, G. C., Feeley, J. C. 1978b. A micro-ELISA test for detecting antibodies, pp. 169–175. In: Jones, G. L., Hébert, G. A. (eds.), “Legionnaires’“: The disease, the bacterium and methodology. Atlanta: Center for Disease Control.

    Google Scholar 

  • Farshy, C. E., Klein, G. C., Feeley, J. C. 1978c. A micro-agglutination test for detecting antibodies, pp. 163–168. In: Jones, G. L., Hébert, G. A., (eds.), “Legionnaires’”: The disease, the bacterium and methodology. Atlanta: Center for Disease Control.

    Google Scholar 

  • Feeley, J. C., Gorman, G. W., Gibson, R. J. 1978. Primary isolation media and methods, pp. 108–117. In: Jones, G. L., Hebert, G. A. (eds.), “Legionnaires’ “: The disease, the bacterium and methodology. Atlanta: Center for Disease Control: revised October, 1978.

    Google Scholar 

  • Feeley, J. C., Gorman, G. W., Weaver, R. E., Mackel, D. C., Smith, H. W. 1978. Primary isolation media for Legionnaires disease bacterium. Journal of Clinical Microbiology 8:320–325.

    PubMed  CAS  Google Scholar 

  • Finnerty, W. R., Makula, R. A., Feeley, J. C. 1979. Cellular lipids of the Legionnaires’ disease bacterium. Annals of Internal Medicine 90:631–633.

    Article  PubMed  CAS  Google Scholar 

  • Fliermans, C. B., Cherry, W. B., Orrison, L. H., Thacker, L. 1979. Isolation of Legionella pneumophila from nonepidemic-related aquatic habitats. Applied and Environmental Microbiology 37:1239–1242.

    PubMed  CAS  Google Scholar 

  • Fraser, D. W., Tsai, T. R., Orenstein, W., Parkin, E. E., Beecham, J., Sharrar, R. G., Harris, J., Mallison, G. F., Martin, S. M., McDade, J. E., Shepard, C. C., Brachman, P. S., and the Field Investigation Team 1977. Legionnaires’ disease description of an epidemic of pneumonia. New England Journal of Medicine 297:1189–1197.

    Article  PubMed  CAS  Google Scholar 

  • George, J. R., Pine, L., Reeves, M. W., Harrell, W. K. 1980. Amino acid requirements of Legionella pneumophila. Journal of Clinical Microbiology 11:286–291.

    PubMed  CAS  Google Scholar 

  • Glick, T. H., Gregg, M. B., Berman, B., Mallison, G., Rhodes, W. R., Jr., Kassanoff, I. 1978. Pontiac Fever, an epidemic of unknown etiology in a health department: I. Clinical and epidemiology aspects. American Journal of Epidemiology 107:149–160.

    PubMed  CAS  Google Scholar 

  • Guerrant, G. O., Lambert, M. S., Moss, C. W. 1979. Identification of diaminopimelic acid in the Legionnaires disease bacterium. Journal of Clinical Microbiology 10:815–818.

    PubMed  CAS  Google Scholar 

  • Haley, C. E., Cohen, M. L., Halter, J., Meyer, R. D. 1979. Nosocomical Legionnaires’ disease: A continuing common source epidemic at Wadsworth Medical Center. Annals of Internal Medicine 90:583–586.

    Article  PubMed  CAS  Google Scholar 

  • Hébert, G. A., Steigerwalt, A. G., Brenner, D. J. 1980. Legionella micdadei species nova: Classification of a third species of Legionella associated with human pneumonia. Current Microbiology 3:255–257.

    Article  Google Scholar 

  • Hébert, G. A., Moss, C. W., McDougal, L. K., Bozeman, F. M., McKinney, R. M., Brenner, D. J. 1980a. The rickett-sia-like organisms TATLOCK (1943) and HEBA (1959): Bacteria phenotypically similar to, but genetically distinct from Legionella pneumophila and the WIGA bacterium. Annals of Internal Medicine 92:45–52.

    Article  PubMed  Google Scholar 

  • Hébert, G. A., Thomason, B. M., Harris, P. P., Hicklin, M. D., McKinney, R. M. 1980b. “Pittsburgh pneumonia agent”: A bacterium phenotypically similar to Legionella pneumophila and identical to the TATLOCK bacterium. Annals of Internal Medicine 92:53–54.

    Article  PubMed  Google Scholar 

  • Jackson, E. B., Crocker, T. T., Smadel, J. E. 1952. Studies on two rickettsia-like agents probably isolated from guinea pigs. Bacteriological Proceedings 1952:119.

    Google Scholar 

  • Kirby, B. D., Snyder, K. M., Meyer, R. D., Finegold, S. M. 1978. Legionnaires’ disease: Clinical features of 24 cases. Annals of Internal Medicine 89:297–309.

    Article  PubMed  CAS  Google Scholar 

  • Klein, G. C. 1980. Cross reaction to Legionella pneumophila antigen in sera with elevated titers to Pseudomonas pseudo-mallei. Journal of Clinical Microbiology 11:27–29.

    PubMed  CAS  Google Scholar 

  • Lattimer, G. L., McCrone, C., Galgon, J. 1978. Diagnosis of Legionnaires’ disease from transtracheal aspirate by direct fluorescent-antibody staining and isolation of the bacterium. New England Journal of Medicine 299:1172–1173.

    Article  PubMed  CAS  Google Scholar 

  • Lewallen, K. R., McKinney, R. M., Brenner, D. J., Moss, C. W., Dail, D. H., Thomason, B. M., Bright, R. A. 1979. A newly identified bacterium phenotypically resembling, but genetically distinct from, Legionella pneumophila: An isolate in a case of pneumonia. Annals of Internal Medicine 91:831–834.

    Article  PubMed  CAS  Google Scholar 

  • McDade, J. E., Brenner, D. E., Bozeman, F. M. 1979. Legionnaires’ disease bacterium isolated in 1947. Annals of Internal Medicine 90:659–661.

    Article  PubMed  CAS  Google Scholar 

  • McDade, J. E., Shepard, C. C. 1979. Virulent to avirulent conversion in the Legionnaires’ disease bacterium (Legionella pneumophila)—its effect on isolation techniques. Journal of Infectious Diseases 139:707–711.

    Article  PubMed  CAS  Google Scholar 

  • McDade, J. E., Shepard, C. C., Fraser, D. W., Tsai, T. R., Redus, M. A., Dowdle, W. R., and the Laboratory Investigation Team 1977. Legionnaires’ disease. Isolation of a bacterium and demonstration of its role in other respiratory disease. New England Journal of Medicine 297:1197–1203.

    Article  PubMed  CAS  Google Scholar 

  • McKinney, R. M., Thacker, L., Harris, P. B., Lewallen, K. R., Hebert, G. A., Edelstein, P. H., Thomason, B. M. 1979. Four serogroups of Legionnaires ‘ disease bacteria defined by direct immunofluorescence. Annals of Internal Medicine 90:621–624.

    Article  PubMed  CAS  Google Scholar 

  • McKinney, R. M., Wilkinson, H. W., Sommers, H. M., Fikes, B. J., Sasseville, K. R., Yungbluth, M. M., Wolf, J. S. 1980. Legionella pneumophila serogroup six: Isolation from cases of legionellosis, identification by immunofluorescence staining and immunologic response to infection. Journal of Clinical Microbiology 12:395–401.

    PubMed  CAS  Google Scholar 

  • Morris, G. K., Patton, C. M., Feeley, J. C., Johnson, S. E., Gorman, G., Martin, W. T., Skaliy, P., Mallison, G. F., Politi, B. D., Mackel, D. C. 1979. Isolation of Legionnaires’ disease bacterium from environmental samples. Annals of Internal Medicine 90:664–666.

    Article  PubMed  CAS  Google Scholar 

  • Moss, C. W., Dees, S. B. 1979. Cellular fatty acid composition of WIGA, a rickettsia-like agent similar to the Legionnaires’ disease bacterium. Journal of Clinical Microbiology 10:390–391.

    PubMed  CAS  Google Scholar 

  • Moss, C. W., Weaver, R. E., Dees, S. B., Cherry, W. B. 1977. Cellular fatty acid composition of isolates from Legionnaires disease. Journal of Clinical Microbiology 6:140–143.

    PubMed  CAS  Google Scholar 

  • Oshima, M., Miyagawa, A. 1974. Comparative studies on the fatty acid composition of moderately and extremely thermophilic bacteria. Lipids 9:476–480.

    Article  PubMed  CAS  Google Scholar 

  • PascuUe, A. W., Myerowitz, R. L., Rinaldo, C. R., Jr. 1979. New bacterial agent of pneumonia isolated from renal-transplant recipients. Lancet ii:58–61.

    Article  Google Scholar 

  • PascuUe, A. W., Feeley, J. C., Gibson, R. J., Cordes, L. G., Myerowitz, R. L., Patton, CM., Gorman, G. W., Carmack, C. L., Ezzell, J. W., Dowling, J. M. 1980. Pittsburgh pneumonia agent: Direct isolation from human lung tissue. Journal of Infectious Diseases 141:727–732.

    Article  Google Scholar 

  • Pine, L., George, J. R., Reeves, M. W., and Harrell, W. K. 1979. Development of a chemically defined liquid medium for the growth of Legionella pneumophila. Journal of Clinical Microbiology 9:615–626.

    PubMed  CAS  Google Scholar 

  • Ristroph, J. D., Hedlund, K. W., Allen, R. G. 1980. Liquid medium for growth of Legionella pneumophila. Journal of Clinical Microbiology 11:19–21.

    PubMed  CAS  Google Scholar 

  • Skaliy, P., McEachern, H. V. 1979. Survival of the Legionnaires’ disease bacterium in water. Annals of Internal Medicine 90:662–663.

    Article  PubMed  CAS  Google Scholar 

  • Smalley, D. L., Jaquess, P. A., Layne, J. S. 1980. Selenium-enriched medium for Legionella pneumophila. Journal of Clinical Microbiology 12:32–34.

    PubMed  CAS  Google Scholar 

  • Storch, G., Hayes, P. G., Meyers, J. D., Sulzer, A., Baine, W. B. 1980. Legionnaires’ disease bacterium: Prevalence of antibody reacting with the organism in patients suspected of having infection with Pneumocystis carinii. American Review of Respiratory Disease 121:483–486.

    PubMed  CAS  Google Scholar 

  • Tatlock, H. 1944. A rickettsia-like organism recovered from guinea pigs. Proceedings of the Society of Experimental Biology and Medicine 57:95–99.

    Article  Google Scholar 

  • Thomason, B. M., Chandler, F. M., Hollis, D. G. 1979. Flagella on Legionnaires’ disease bacteria: An interim report. Annals of Internal Medicine 91:224–226.

    Article  PubMed  CAS  Google Scholar 

  • Thomason, B. M., Harris, P. P., Hicklin, M. D., Blackmon, J. A., Moss, C. W., Matthews, F. 1979. Detection of a Legionella-like bacterium related to WIG A in a fatal case of pneumonia. Annals of Internal Medicine 91:673–676.

    Article  PubMed  CAS  Google Scholar 

  • Thomason, B. M., Harris, P. P., Lewallen, K. R., McKinney, R. M. 1979. Preparation and testing of a poly valent conjugate for direct fluorescent-antibody detection of Legionella pneumophila. Current Microbiology 2:357–360.

    Article  Google Scholar 

  • Thornsberry, C., Kirven, L. A. 1978. β-Lactamase of the Legionnaires’ bacterium. Current Microbiology 1:51–54.

    Article  CAS  Google Scholar 

  • Tilton, R. C. 1979. Legionnaires’ disease antigen detected by enzyme-linked immunosorbent assay. Annals of Internal Medicine 90:697–698.

    Article  PubMed  CAS  Google Scholar 

  • Tison, D. L., Pope, D. H., Cherry, W. B., Fliermans, C. B. 1980. Growth of Legionella pneumophila in association with blue green algae (cyanobacteria). Applied and Environmental Microbiology 39:456–459.

    PubMed  CAS  Google Scholar 

  • Wang, W. L. L., Blaser, M. J., Cravens, J., Johnson, M. A. 1979. Growth, survival, and resistance of the Legionnaires’ disease bacterium. Annals of Internal Medicine 90:614–618.

    Article  PubMed  CAS  Google Scholar 

  • Watts, J. C., Hicklin, M. D., Thomason, B. M., Callaway, C. S., Levine, A. J. 1980. Fatal pneumonia caused by Legionella pneumophila, serogroup 3: Demonstration of the bacilli in extrathoracic organs. Annals of Internal Medicine 92:186–188.

    Article  PubMed  CAS  Google Scholar 

  • Weaver, R. E. 1978. Cultural and staining characteristics, pp. 39–43. In: Jones, G. L., Hébert, G. A. (eds.), “Legionnaires’ “: The disease, the bacterium and methodology. Atlanta: Center for Disease Control.

    Google Scholar 

  • Wilkinson, H. W., Fikes, B. J., and Cruce, D. D. 1979. Indirect immunofluorescence test for serodiagnosis of Legionnaires disease: Evidence for serogroup diversity of Legionnaires disease bacterial antigens and for multiple specificity of human antibodies. Journal of Clinical Microbiology 9:379–383.

    PubMed  CAS  Google Scholar 

  • Wilkinson, H. W., Farshy, C. E., Fikes, B. J., Cruce, D. D., Yealy, L. P. 1979. Measure of immunoglobulin G-, M-, and A-specific titers against Legionella pneumophila and inhibition of titers against nonspecific, Gram-negative bacterial antigens in the indirect immunofluorescence test for legionellosis. Journal of Clinical Microbiology 10:685–689.

    PubMed  CAS  Google Scholar 

  • Winn, W. C., Galvin, F. L., Perl, D. P., Keller, J. L., Andres, T. L., Brown, T. M., Coffin, C. M., Sensecqua, J. E., Roman, L. N., Craighead, J. E. 1978. The pathology of Legionnaires’ disease: Fourteen fatal cases from the 1977 outbreak in Vermont. Archives of Pathology and Laboratory Medicine 102:344–350.

    PubMed  Google Scholar 

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Balows, A., Brenner, D.J. (1981). The Genus Legionella . In: Starr, M.P., Stolp, H., Trüper, H.G., Balows, A., Schlegel, H.G. (eds) The Prokaryotes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-13187-9_87

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