Abstract
There have been suggestions, in view of the striking anatomic juxtaposition of the A- and B-cells (Haist 1965; Epple 1968; Orci et al. 1975) that these cells might influence the secretion of one another. The studies of Samols, Marks and colleagues, based on the demonstrations that glucagon stimulated insulin secretion (Samols et al. 1965 a, 1966 a) and that insulin suppressed glucagon secretion (Samols et al. 1970, 1972; Samols and Harrison 1976) and of the conditions favoring or inhibiting these actions (Samols et al. 1965 b, 1966 b, 1969 a, b; Samols and Marks 1967; Porte et al. 1966) led to the construction of their hypothesis of positive-negative insulin-glucagon feedback within the islets (Samols et al. 1970, 1972). Not surprisingly, in view of its multiple separations from orthodox concepts, and because of its implications, this hypothesis has been controversial. On the one hand, this hypothesis and its subsequent development continues to be contentious (more so in terms of the insulinotropic effect of glucagon than of the glucagonosuppressive effect of insulin). On the other hand, the discovery of pancreatic somatostatin renewed interest in the concept of paracrine insular control mechanisms (Unger and Orci 1977). Consideration of the possible paracrine interrelationships of somatostatin, insulin, and glucagon, is presented in Chap. 31. The present chapter is primarily concerned with the interrelationships between glucagon and insulin, in particular with regard to the hypothesis of Samols and Marks, and to its further development in terms of more recent information and concepts.
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Samols, E. (1983). Glucagon and Insulin Secretion. In: Lefèbvre, P.J. (eds) Glucagon I. Handbook of Experimental Pharmacology, vol 66 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68866-9_22
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