Summary
Nine normal children (6 males and 3 females) aged from 7 1/2 to 14 1/2 years underwent a 30-min arginine infusion (0.5 g/kg) followed at 90 min by one bolus i.v. glucagon injection (0.03 mg/kg). On a separate occasion the same children underwent an i.v. glucagononly test. No significant difference was found when the glucose and insulin responses in the two glucagon tests were compared, in contrast to previous findings that preloading with glucose resulted in a significantly increased response of insulin to glucagon.
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Cerasi E., Luft R., Efendić S.: Effect of adrenergic blocking agents on insulin response to glucose infusion in man — Acta endocr. (Kbh.)69, 335, 1972.
Hales C.N., Randle P. J.: Immunoassay of insulin with insulin-antibody precipitate — Biochem. J.88, 137, 1963.
Josefsberg Z., Flatau E., Doron M., Laron Z.: The influence of oral glucose loading on the insulin response to i.v. glucagon in children and adolescents — Metabolism25, 277, 1976.
Laron Z.: The hypothalamus and the pituitary gland (hypophysis) — In:Hubble D. (Ed.): Paediatric endocrinology. Blackwell Sci. Publ., Oxford, 1969; p. 54.
Laron Z., Mimouni M., Josefsberg Z., Zadik Z., Doron M.: The effect of HGH deficiency on the insulin response to glucagon after oral glucose loading — (Submitted for publication).
Rodbell M., Birnbauer L., Pohl S. L.: Characteristics of glucagon action on the hepatic adenylate cyclase system — Biochem. J.125, 58, 1975.
Widstrom A., Cerasi E.: On the action of tolbutamide in normal man. III. Interaction of tolbutamide with glucagon, aminophylline and arginine in stimulating insulin response — Acta endocr. (Kbh.)72, 532, 1973.
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Established Investigator of the Chief Scientist’s Bureau Ministry of Health.
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Blum, I., Doron, M. & Laron, Z. Lack of influence of arginine preloading on the insulin response to I.V. glucagon in children and adolescents. Acta diabet. lat 15, 68–71 (1978). https://doi.org/10.1007/BF02581008
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DOI: https://doi.org/10.1007/BF02581008