Abstract
The prostaglandins (PGs) are a group of lipid-soluble C20-carboxylic acids containing an oxygenated five-membered ring and two parallel aliphatic side-chains. Chemically they are named as substituted prostenoic (1) or prostadienoic (2) acids.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Adams, S.S., Bresloff, P., Risdall, P.C.: The contribution of metabolism to the anti-inflammatory activity of flurbiprofen. Scand. J. Rheum. 4 Suppl.8, S11-S19 (1975)
Anderson, N.H., Ramwell, P.W., Leovey, E.M.K., Hohnson, M.: Biological consequences of prostaglandin molecular conformations. In: Samuelsson, B., Paoletti, R. (Eds.): Advances in Prostaglandin and Thromboxane Research, Vol. I, pp. 271–289. New York: Raven Press 1976
Arturson, G., Jonsson, C.E.: Stimulation and inhibition of biosynthesis of prostaglandins in human skin by some hydroxyethylated rutosides. Prostaglandins 10, 941–948 (1975)
Beatty, C.H., Bocek, R.M., Young, M.K., Novy, M.J.: Effect of indomethacin on cyclic AMP phosphodiesterase activity in myometrium from pregnant rhesus monkeys. Prostaglandins 11, 713–725(1976)
Bennett, A., Posner J.: Studies on prostaglandin antagonists. Brit. J. Pharmacol. 42, 584–594 (1971)
Bhattacherjee, P., Eakins, K.E.: Inhibition of the ocular effects of sodium arachidonate by antiinflammatory compounds. Prostaglandins 9, 175–182 (1975)
Blackwell, G.J., Flower, R.J., Vane, J.R.: Some characteristics of the prostaglandin synthesizing system in rabbit kidney microsomes. Biochim. biophys. Acta 398, 178–190 (1975)
Brune, K., Glatt, M., Graf, P.: Mechanisms of action of anti-inflammatory drugs. Gen. Pharmacol. 7, 27–33 (1976)
Brune, K., Graf, P., Glatt, M.: Inhibition of prostaglandin synthesis in vivo by non-steroid antiinflammatory drugs: evidence for the omportance of pharmacokinetics. Agents Actions 6, 159–164(1976)
Bundy, G.L.: The synthesis of prostaglandin endoperoxide analogs. Tetrahedron Lett. 1975–1960 (1975)
Carminati, P., Lerner, L.J.: Effect of diftalone and other nonsteroidal anti-inflammatory agents on synthesis of prostaglandins. Proc. Soc. exp. Biol. (N.Y.) 148, 455–458 (1975)
Chan, J.A., Nagasawa, M., Takeguchi, C., Sih, C.J.: On agents favouring prostaglandin F formation during biosynthesis. Biochemistry 14, 2987–2991 (1975)
Ciosek, C.P. Jr., Ortel, R.W., Thanassi, N.M., Newcombe, D.S.: Indomethacin potentiates PGE, stimulated cyclic AMP accumulation in human synovidcytes. Nature (Lond.) 251, 148–150 (1974)
Collier, H.O.J., Francis, A.A., McDonald-Gibson, W.J., Saeed, S.A.: Inhibition of prostaglandin biosynthesis by sulphasalazine and its metabolites. Prostaglandins 11, 219–225 (1976)
Collier, H.O.J., McDonald-Bibson, W.J.: Inhibition by drugs on the stimulation of prostaglandin biosynthesis induced by apomorphine. International Conference on Prostaglandins, Florence, 1975, pp 27, Abs. 1975
Corey, E.T., Nicolaou, K.C., Machida, C.Y., Malmsten, C.L., Samuelsson, B.: Synthesis and biological properties of 9, 11–920-prostanoid: highly active biochemical mimic of prostaglandin endoperoxides. Proc. nat. Acad. Sci. (Wash.) 72, 3355–3358 (1975)
Corey, E.J., Shibasaki, M., Nicolaou, K.C., Malmsten, C.L., Samuelson, B.: Simple stereocon-trolled total synthesis of a biologically active analog of the prostaglandin endoperoxides (PGH2, PGG2). Tetrahedron Lett. 737–740 (1976)
Crook, D., Collins, A.J.: Prostaglandin synthetase activity from human rheumatoid synovial tissue and its inhibition by nonsteroidal anti-inflammatory drugs. Prostaglandins 9, 857–865 (1975)
Cushman, D.W., Cheung, H.S.: Effect of substrate concentration on inhibition of prostaglandin synthetase of bull seminal vesicles by anti-inflammatory drugs and fenamic acid analogs. Biochim. biophys. Acta 424, 449–459 (1976)
Damon, A., Heimberg, M., Oates, J.A.: Enrichment of rat tissue lipid with fatty acids that are prostaglandin precursors. Biochim. biophys. Acta 388, 318–330 (1975)
Deby, C., Bacq, Z.M., Simon, D.: In vitro inhibition of the biosynthesis of a prostaglandin by gold and silver. Biochem. Pharmacol. 22, 3141–3243 (1973)
Deby, C., Descamps, M., Binon, F., Bacq, Z.M.: Correlation between anti-inflammatory properties and inhibition of prostaglandin biosynthesis in vitro. Biochem. Pharmacol. 24, 1089–1092 (1975)
De Clerck, F., Vermylen, J., Reneman, R.: Effects of suprofen, an inhibitor of prostaglandin biosynthesis, on platelet function, plasma coagulation and fibrinolysis. II. In vivo experiments. Arch. int. Pharmacodyn. 217, 68–79 (1975)
Dembinska-Kiec, A., Zmuda, A., Krupinska, J.: Inhibition of prostaglandin synthetase by aspirinlike drugs in different microsomal preparations. In: Samuelsson, B., Paoletti, R. (Eds.): Advances in Prostaglandin and Thromboxane Research, Vol. I, pp. 99–103. New York: Raven Press 1976
Downing, D.T., Barve, J.A., Gunstone, F.D., Jacobsberg, M., Lie, K.J.: Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthetase. Biochem. biophys. Acta. 280, 343–347 (1972)
Duvivier, J., Wolf, D., Heusghem, C.: Enzymatic properties of prostaglandin synthetase for bovine seminal vesicles. Biochimie 57, 521–528 (1975)
Egan, R.W., Eckert, C.A., Galavage, M., Humes, J.L., Kuehl, Jr., F.A.: The influence of phenols and related compounds on inhibition of prostaglandin biosynthesis by nonsteroidal antiinflammatory agents. Fed. Proc. 35, 1652 (1976)
Egan, R.W., Paxton, J., Kuehl, F.A., Jr.: Mechanism for irreversible self-deactivation of prostaglandin synthetase. J. biol. Chem., 251, 7329–7335 (1976)
Ferreira, S.H., Moncada, S., Vane, J.R.: Indomethacin and aspirin abolish prostaglandin release from the spleen. Nature (New Biol.) 231, 237–239 (1971)
Ferreira, S.H., Vane, J.R.: New aspects of the made of action of non-steroidal anti-inflammatory drugs. Ann. Rev. Pharmacol. 14, 57–73 (1974)
Flower, R.J.: Drugs which inhibit prostaglandin biosynthesis. Pharmacol. Rev. 26, 33–67 (1964)
Flower, R.J., Blackwell, G.J.: The importance of phospholipase-A2 in prostaglandin biosynthesis. Biochem. Pharmacol. 25, 285–291 (1976)
Flower, R.J., Cheung, H.S., Cushman, D.W.: Quantitative determination of prostaglandins and malondialdehyde formed by the arachidonate oxygenase (prostaglandin synthetase) system of bovine seminal vesicle. Prostaglandins 4, 325–341 (1973)
Flower, R.J., Vane, J.R.: Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol. Nature (New Biol.) 240, 410–411 (1972)
Flower, R.J., Vane, J.R.: Inhibition of prostaglandin biosynthesis. Biochem. Pharmacol. 23, 1439–1450 (1974)
Förström, Goldyne, M.E., Winkelmann, R.K.: Prostaglandin production by human epidermal cells in vitro: a model for studying pharmacologic inhibition of prostaglandin synthesis. Prostaglandins 8, 107–115 (1974)
Gaut, Z.N., Baruth, H., Randall, L.O., Ashley, C., Paulstrud, J.R.: Stereoisometric relationships among anti-inflammatory activity, inhibition of platelet aggregation, and inhibition of prostaglandin synthetase. Prostaglandins 10, 59–66 (1976)
Greaves, M.W., McDonald-Gibson, M.J.: Anti-inflammatory agents and prostaglandin biosynthesis. Brit. med. J. 5825, 527 (1972)
Greenberg, R.: Some pharmacological effects of prodolic acid, a new anti-inflammatory compound, indicative of inhibition of prostaglandin synthesis. Canad. J. Physiol. Pharmacol. 53, 186–189 (1975)
Gryglewski, R.J., Ryznerski, Z., Gorczyca, M., Krupinska, J.: Design of new prostaglandin synthetase inhibitors in a group of N-(2-carboxy-phenyl) phenoxy acetomides and their antiinflammatory activity. In: Samuelson, B., Paoletti, R. (Eds.): Advances in Prostaglandin and Thromoxane Research, Vol. I, pp. 117–120. New York: Raven Press 1976
Gund, P., Shen, T.Y.: A model for the prostaglandin synthetase cyclooxygenation site and its inhibition by antiinflammatory arylacetic acids. J. med. Chem. 20, 1146–1152 (1977)
Ham, E.A., Studies on the mode of action of non-steroidal anti-inflammatory agents. In: Ram-well, P. W., Pharriss, B.B. (Eds.): Prostaglandins in Cellular Biology, pp. 345–352. New York: Plenum Press 1972
Hamberg, M., Samuelson, B.: On the metabolism of prostaglandin E1 and E2 in the guinea pig. J. biol. Chem. 247, 3495 (1972)
Hamberg, M., Svensson, J., Samuelson, B.: Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc. nat. Acad. Sci. (Wash.) 72, 2994–2998 (1975)
Hansen, H.S.: Inhibition by indomethacin and aspirin of 15-hydroxyprostaglandin dehydrogenase in vitro. Prostaglandin 8, 95–111 (1974)
Hirschmann, R., Strachan, R.G., Buchschacher, P., Sarett, L.H., Steelman, S.L., Silber, R.: An approach to an improved anti-inflammatory steroid, the synthesis of 11β, 17-dihydroxy-3, 20-dione-l, 4-pregnadien-21-yl 2-acetamido-2-deoxy-β-D-glucopyrandoside. J. Amer. chem. Soc. 86, 3903 (1964)
Ho, P.P.K., Esterman, M.A.: Fenoprofen: inhibitor of prostaglandin synthesis. Prostaglandins 6, 107–113(1974)
Hong, S.C.L., Levine, L.: Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids. Proc. nat. Acad. Sci. (Wash.) 73, 1730–1734 (1976)
Hoogsteen, K., Trenner, N.R.: Structure and conformation of cis and trans isomers of 1-(p- chlorobenzylindene)-2-methyl-5-methoxy-3-indenyl acetic acid. J. org. Chem. 35, 521 (1970)
Horodniak, J.W., Julius, M., Zarembo, J.E., Bender, A.D.: Inhibitory effects of aspirin and indomethacin on the biosynthesis of PGE2 and PGF2α. Biochem. biophys. Res. Commun. 57, 539–545 (1974)
Horodniak, J.W., Matz, E.D., Walz, D.T., Sutton, B.M., Berkoff, C.E., Zarembo, J.E., Bender, D.A.: Inhibition of prostaglandin synthetase and carageenan-induced edema by tricyclic analogs of flufenamic acid. Res. Commun. chem. Path. Pharmacol. 11, 533–542 (1975)
Hsia, S.L., Ziboh, V.A., Snyder, D.S.: Naturally occurring and synthetic inhibitors of prostaglandin synthetase of the skin. In: Vane, J.R., Robinson, H.R. (Eds.): Prostaglandin Synthetase Inhibitors, pp. 353–361. New York: Raven Press 1974
Jaffe, I.: U.S. Patent, No. 3, 852, 454 (1974)
Kantrowitz, F., Robinson, D.R., McCuire, M.B., Levine, L.: Corticosteroids inhibit prostaglandin production by rheumatoid synovia. Nature (Lond.) 258, 737–739 (1975)
Kistenmacher, T. J., Marsh, R.E.: Crystal and molecular structure of an anti-inflammatory agent, indomethacin, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-acetic acid. J. Amer. chem. Soc. 94, 1340–1345(1972)
Krupp, P., West, M.: Inhibition of prostaglandin synthetase by psychotropic drugs. Experientia (Basel) 31, 330–331 (1975)
Ku, E.C., Wasvary, J.M.: Inhibition of prostaglandin synthetase by pirprofen studies with sheep seminal vesicle enzyme. Biochim. biophys. Acta 384, 360–368 (1975)
Kuehl, F.A., Jr., Humes, J.L., Beveridge, G.C., Van Arman, C.G., Egan, R.W.: Biologically active derivatives of fatty acids, prostaglandins, thromboxanes and endoperoxides. Inflammation 2, 285–294(1977)
La Hann, T.R., Horita, A.: Effects of dimethyl sulfoxide (DMSO) on prostaglandin synthetase. Proc. West, pharmacol. Soc. 18, 81–82 (1975)
Lands, W.E.M., Cook, H.W., Rome, L.H.: Prostaglandin biosynthesis: consequences of oxygenase mechanism upon in vitro assays of drug effectiveness. In: Samuelsson, B., Paoletti, R. (Eds.): Advances in Prostaglandin and Thromboxane Research, Vol. I, pp. 7–17. New York: Raven Press 1976
Lee, R.E.: The influence of psychotropic drugs and prostaglandin biosynthesis. Prostaglandins 5, 63–72 (1974)
Leeney, T.J., Marsham, P.R., Ritchie, G.A.F., Senior, M.W.: Inhibitors of prostaglandin biosynthesis: a bicyclo-(2, 2, 1)-peptene analogue of “2” series prostaglandins and related derivatives. Prostaglandins 11, 953–960 (1976)
Leovey, E.M.K., Anderson, N.H.: Molecular basis of prostaglandin potency. II. Proton NMR studies of the conformation of prostaglandin F2α. Prostaglandins 10, 789–794 (1975)
Lerner, L.J., Carminati, P., Schiatti, P.: Correlation of anti-inflammatory activity with inhibition of prostaglandin synthesis activity of nonsteroidal anti-estrogens and estrogens. Proc. Soc. exp. Biol. (N.Y.) 148, 329–332 (1975)
Lewis, G.P., Piper, P.J.: Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory cortico-steroids. Nature (Lond.) 254, 308–311 (1975)
Majerus, P.W., Stanford, N.: Comparative effects of aspirin and diflunisal on prostaglandin synthetase from human platelets and sheep seminal vesicles. Brit. J. clin. Pharmac. 4, 15S-18S (1977)
Malmsten, C.: Some biological effects of prostaglandin endoperoxide analogs. Life Sci. 18, 169–176 (1976)
McDonald-Gibson, R.G., Flack, J.D., Ramwell, P.W.: Inhibition of prostaglandin biosynthesis by 7-oxa and 5-oxa-prostaglandin analogues. Biochem. J. 132, 117–120 (1973)
Miyamoto, T., Ogino, N., Yamamoto, S., Hayaishi, O.: Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. J. biol. Chem. 251, 2629–2636 (1976)
Moncada, S., Gryglewski, R., Bunting, S., Vane, J.R.: An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263, 663–665(1976)
Newcombe, D.S., Thanassi, N.M., Ciosek, C.P. Jr.: Cartilage cyclic nucleotide phosphodiesterase inhibition by anti-inflammatory agents. Life Sci. 14, 505–519 (1974)
Nuss, G.W., Smyth, R.D., Dreder, C.H., Hitchings, M.J., Mir, G.N., Reavey-Cartwell, N.H.: Fen-cloras, a new nonsteroidal anti-inflammatory agent. Fed. Proc. 35, 774 (1976)
Oien, H.G., Mandel, L.R., Humes, J.L., Taub, D., Hoffsommer, R.D., Kuehl, F.A. Jr.: Structural requirements for the binding of prostaglandins. Prostaglandins 9, 985–995 (1975)
Panganamala, R.V., Sharma, H.M., Geer, J.G., Cornwell, D.G.: A suggested role for hydrogen peroxide in the biosynthesis of prostaglandins. Prostaglandins 8, 3–11 (1974)
Panganamala, R.V., Sharma, H.M., Heikila, R.E., Geer, J.C., Cornwell, D.G.: Role of hydroxyl radical scavengers dimethyl sulfoxide, alcohols, and methional in the inhibition of prostaglandin biosynthesis. Prostaglandins 11, 599–607 (1976)
Patrono, C., Ciabattoni, G., Greco, F., Grossi-Belloni, D.: Comparative evaluation of the inhibitory effects of aspirin-like drugs on prostaglandin production by human platelets and synovial tissue. In: Samuelsson, B., Paoletti, R. (Eds.): Advances in Prostaglandins and Thromboxane Research, Vol. I, pp. 125–131. New York: Raven Press 1976
Patrono, C., Ciabattoni, G., Grossi-Belloni, D.: In vitro and in vivo inhibition of prostaglandin synthesis by fenoprofen, a nonsteroid anti-inflammatory drug. Pharmacol. Res. Commun. 6, 509–518(1974)
Patrono, C., Ciabattoni, G., Grossi-Belloni, D.: Release of prostaglandin Flα and F2α from super-fused platelets: quantitative evaluation of the inhibitory effects of some aspirin-like drugs. Prostaglandins 9, 557–568 (1975)
Penneys, N.S., Ziboh, Gottlieb, N.L., Katz, S.: Inhibition of prostaglandin synthesis and human epiderman enzymes by aurothiomalate in vitro: possible actions of gold in pemphigus. J. invest. Derm. 63, 356–361 (1974)
Polonovski, J., Bard, D., Bereziat, G., Colard, O.: Modifications de la Synthese des Prostaglandines dans le foie de rat sous Tinfluence de l’insuline et du glucagon. CR. Soc. Biol. (Paris) 168, 1208–1215(1975)
Pong, S.S., Levine, L.: Prostaglandin synthetase systems of rabbit tissues and their inhibition by nonsteroidal anti-inflammatory drugs. J. Pharmacol, exp. Ther. 196, 226–230 (1976)
Procaccini, R.L., Smyth, R.D., Rush, K., Reavey-Cantwell, N.H.: Studies on the inhibition of prostaglandin synthetase by fenclorac, a new nonsteroidal anti-inflammatory agent. Fed. Proc. 35, 774 (1976)
Robinson, D.R., McCuire, M.B., Bastian, D.E.: Corticosteroid inhibition of prostaglandin synthesis by rheumatoid synovia. Fed. Proc. 35, Abstract 735 (1976)
Robinson, D.R., Smith, H., McGuire, M.B., Levine, L.: Prostaglandin synthesis by rheumatoid synovium and its stimulation by colchicine. Prostaglandins 10, 67–85 (1975)
Rome, L.H., Lands, W.E.M.: Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs. Proc. nat. Acad. Sci. (Wash.) 72, 4863–4865 (1975)
Rome, L.H., Lands, W.E.M., Roth, G.J., Majerus, P.W.: Aspirin as a quantitative acetylating reagent for the fatty acid oxygenase that forms prostaglandins. Prostaglandins 11, 23–29 (1976)
Roth, G.J., Stanford, N., Majerus, P.W.: Acetylation of prostaglandin synthase by aspirin. Proc. nat. Acad. Sci. (Wash.) 72, 3073–3076 (1975)
Scherrer, R.A.: Introduction to the chemistry of anti-inflammatory and anti-arthritic agents. In: Scherrer, R. A., Whitehouse, M. W. (Eds.): Anti-inflammatory Agents, Vol. I, pp. 29–43. New York: Academic Press 1974
Shen, T.Y.: Synthesis and biological activity of some indomethacin analogs. In: Proceedings International Symposium on Nonsteroidal Anti-inflammatory Drugs, pp. 13–20, 1964
Shen, T.Y.: Perspectives in non-steroidal anti-inflammatory agents. Angew. Chemie 11, 460–472 (1972)
Shen, T.Y., Ham, E.A., Cirillo, V.J., Zanetti, M.: Structure-activity relationship of certain prostaglandin synthetase inhibitors. In: Vane, J.R., Robinson, H.R. (Eds.): Prostaglandin Synthetase Inhibitors, pp. 19–31. New York: Raven Press 1974
Shen, T.Y., Witzel, B.E., Jones, H., Linn, B.O., McPherson, J., Greenwald, R., Fordice, M., Jacobs, A.: Synthesis of a new anti-inflammatory agent, cis-5-fluoro-2-methyl-l-(p-methylsulfinyl) benzylidenyl) indene-3-acetic acid. Fed. Proc. 31, 577 (1972)
Smith, J.B., Willis, A.L.: Aspirin selectively inhibits prostaglandin production in human platelets. Nature (New Biol.) 231, 235–237 (1971)
Smith, M.J.H., Ford-Hutchinson, A.W., Elliott, P.N.C.: Prostaglandins and the anti-inflammatory activities of aspirin and sodium salicylate. J. Pharm. (Lond.) 27, 473–478 (1975)
Smith, W.L., Lands, W.E.M.: Stimulation and blockade of prostaglandin biosynthesis. J. biol. Chem. 246, 6700–6702 (1971)
Steelman, S.L., Smit Sibinga, C.T., Schulz, P., Van den Heuvel, W.J.H., Tempero, K.F.: The effect of diflunisal on urinary prostaglandin excretion, bleeding time and platelet aggregation in normal human subjects. In: Proceedings XIII International Congress of Internal Medicine, p. 215, 1976
Stone, K.J., Mathes, S.J., Gibson, P.P.: Selective inhibition of prostaglandin biosynthesis by gold salts and phenylbutazone. Prostaglandins 10, 241–251 (1975)
Takeguchi, C., Kohno, K., Sih, S.J.: Mechanism of prostaglandin biosynthesis. I. Characterisation and assay of bovine prostaglandin synthetase. Biochemistry 10, 2372–2376 (1971)
Takeguchi, C., Sih, S.J.: A rapid spectrophotometric assay for prostaglandin synthetase: application to the study of non-steroidal anti-inflammatory agents. Prostaglandins 2, 169–184 (1972)
Tashjian, A.H. Jr., Voelkel, E.F., McDonough, J., Levine, L.: Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cells. Nature (Lond.) 258, 739–741 (1975)
Tolman, E.L., Birnbaum, J.E., Chiccarelli, F.S., Panagides, J., Sloboda, A.E.: Inhibition of prostaglandin activity and synthesis by fenbufen (a new non-steroidal anti-inflammatory agent) and one of its metabolites. In: Samuelsson, B., Paoletti, R. (Eds.): Advances in Prostaglandin and Thromboxane Research, Vol. I, pp. 133–138. New York: Raven Press 1976
Tolman, E.L., Partridge, R.: Multiple sites of interaction between prostaglandins and nonsteroidal anti-inflammatory agents. Prostaglandins 9, 349–359 (1975)
Van Annan, C.G., Risley, E.A., Nuss, G.W.: Pharmacologic properties of an anti-inflammatory agent 5-fluoro-2-methyl-l-(p-methylsulfinyl benzylidene)-inden-3-yl-acetic acid. Fed. Proc. 31, 577 (1972)
Vanderhoek, J.Y., Lands, W.E.M.: Acetylenic inhibitors of sheep vesicular gland oxygenase. Biochim. biophys. Acta 296, 374–381 (1973)
Vane, J.R.: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (New Biol.) 231, 232 (1971)
Van Nueten, J.M.: Antagonism of arachidonic acid hydroperoxide on isolated gastro-intestinal tissues as a measure of the inhibition of prostaglandin biosynthesis. In: Samuelsson, B., Paoletti, R. (Eds.): Advances in Prostaglandin and Thromboxane Research, Vol. I, pp. 139–145. New York: Raven Press 1976
Vargaftig, B.B., Tranier, Y., Chignard, M.: Inhibition by sulfhydryl agents of arachidonic acid-induced platelet aggregation and release of potential inflammatory substances. Prostaglandins 8, 133–147 (1974)
Vigdahl, R.L., Tukey, R.H.: Inhibition of prostaglandin synthetase by anti-inflammatory agents R-805 and R-807. Pharmacologist 17, 226 (1975)
Wiseman, E.H., McIlhenny, H.M., Bettis, J.W.: Flumizole, a new nonsteroidal anti-inflammatory agent. J. pharm. Sci. 64, 1469–1475 (1975)
Wlodawer, P., Samuelsson, B., Albonico, S.M., Corey, E.J.: Selective inhibition of prostaglandin synthetase by a bicyclo (2, 2, 1, ) heptane derivative. J. Amer. chem. Soc. 93, 2815–2816 (1971)
Yanagi, Y., Komatsu, T.: Inhibition of prostaglandin biosynthesis by SL-573. Biochem. Pharmacol. 25, 937–941 (1976)
Yesair, D.W., Callahan, M., Remington, L., Kenster, C.J.: Role of the enterohepatic cycle of in-domethacin on its metabolism, distribution in tissues, and its excretion by rats, dogs, and monkeys. Biochem. Pharmacol. 19, 1579–1590 (1970)
Ziboh, V.A.: Regulation of prostaglandin E2 biosynthesis in guinea pig skin by retinoic acid. Acta derm.-venereol (Stockh.) 74 Suppl., 56–60 (1975)
Ziboh, V.A., McElligott, T., Hsia, S.L.: Prostaglandin E2 biosynthesis in human skin: subcellular localisation and inhibition by unsaturated fatty acids and anti-inflammatory drugs. Ad vane. Biosci. 9, 457–460 (1973)
Ziel, R., Krupp, P.: The significance of inhibition of prostaglandin synthesis in the selection on nonsteroidal anti-inflammatory agents. Advanc. Biosci. 9, 457–460 (1973)
Ziel, R., Krupp, P.: The significance of inhibition of prostaglandin synthesis in the selection of non-steroidal anti-inflammatory agents. Int. J. clin. Pharmacol. 12, 186–191 (1975)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Shen, T.Y. (1979). Prostaglandin Synthetase Inhibitors I. In: Vane, J.R., Ferreira, S.H. (eds) Anti-Inflammatory Drugs. Handbook of Experimental Pharmacology, vol 50 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66891-3_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-66891-3_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66893-7
Online ISBN: 978-3-642-66891-3
eBook Packages: Springer Book Archive