Abstract
We report a gene amplification of 25-hydroxyvitamin D31, α-hydroxylase and the appearance of various splice variants in glioblastoma multiforme. Some protein products of the widespread expressed variants may exert a biological function. The analysis of amplification and overexpression of alternative transcripts will provide new insights in the regulation of the 25-hydroxyvitamin D31, α-hydroxylase expression and may have implications for prognosis in glioblastoma.
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Ding S, Lake BG, Friedberg T, Wolf CR (1995) Expression and alternative splicing of the cytochrome P450 CYP2A7. Biochem J 306:161–166
Fischer U, Gracia U, Elkahloun A, Trent JM, Meese E, Meltzer PS (1996) Isolation of genes amplified in human cancers by microdissection mediated cDNA capture. Hum Mol Genet 5:595–600
Kleihues P, Burger PC, Collins VP, Newcomb EW, Ohgaki H, Cavenee WK (2000) Glioblastoma. In: Kleihues P, Cavenee WK (eds) Tumors of the nervous system. IARC Press, Lyon, pp 29–39
Maas R, Reus R, Diesel B, Steudel WI, Feiden W, Fischer U, Meese E (2001) Amplification and expression of splice variants of the gene encoding the P450 cytochrome 25-Hydroxyvitamin D3 1,a-hydroxylase (CYP27B1) in human malignant glioma. Clin Cancer Res 7:868–875
Magrassi L, Butti G, Pezzotta S, Infuso L, Milanesi G (1995) Effects of vitamin D and retinoic acid on human glioblastoma cell lines. Acta Neurochir 133:184–190
Picado-Leonard J, Miller WL (1988) Homologous sequences in steroidogenic enzymes, steroid receptors and a steroid binding protein suggest a consensus steroid-binding sequence. Mol Endocrinol 2:1145–1150
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© 2003 Springer-Verlag Berlin Heidelberg
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Diesel, B., Fischer, U., Meese, E. (2003). Gene Amplification and Splice Variants of 25-Hydroxyvitamin D31, α-Hydroxylase (CYP27B1) in Glioblastoma Multiforme— A Possible Role in Tumor Progression?. In: Reichrath, J., Tilgen, W., Friedrich, M. (eds) Vitamin D Analogs in Cancer Prevention and Therapy. Recent Results in Cancer Research, vol 164. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55580-0_11
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DOI: https://doi.org/10.1007/978-3-642-55580-0_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-62435-3
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