Skip to main content
SpringerLink
Log in

Langzeitverlauf nach Beobachtung und chirurgischer Therapie zystischer Pankreasneoplasien

  • Chapter
  • First Online:
Erkrankungen des Pankreas

  • 3784 Accesses

Zusammenfassung

Die Langzeitprognose ist in der Regel bei zystischen Pankreasläsionen (inklusive der malignen Tumoren) deutlich besser als bei duktalen Adenokarzinomen einzustufen. Dennoch unterscheidet sich die individuelle Prognose stark – abhängig von dem jeweilig zugrundeliegenden histologischen Subtyp. Aufgrund der höheren Entartungsrate der Hauptgang-IPMN finden sich die Rezidive auch überwiegend bei diesem Subtyp (ca. 60–80 %). Die Langzeitüberlebensraten korrelieren eng mit dem Nachweis invasiver Areale und sind in diesem Falle deutlich kürzer als bei Patienten ohne Malignitätsnachweis. Bei den muzinösen Zystadenomen hängt die Prognose direkt von einem evtl. Nachweis invasiver Areale ab. Seröse Zystadenome haben eine exzellente Prognose, ein Rezidiv ist bei einer vollständigen Tumorresektion in der Regel nicht zu erwarten. Durch eine operative Therapie können bei den solid-pseudopapillären Neoplasien exzellente Langzeitverläufe mit Heilungsraten > 95 % erreicht werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Arlix A, Bournet B, Otal P, Canevet G, Thevenot A, Kirzin S, Carrere N, Suc B, Moreau J, Escourrou J u. Buscail L (2011) Long-term clinical and imaging follow-up of nonoperated branch duct form of intraductal papillary mucinous neoplasms of the pancreas. Pancreas 41(2): 295–301

    Article  Google Scholar 

  • Bae SY, Lee KT, Lee JH, Lee JK, Lee KH, Rhee JC (2011) Proper management and follow-up strategy of branch duct intraductal papillary mucinous neoplasms of the pancreas. Dig Liver Dis 44(3): 257–260

    Article  PubMed  Google Scholar 

  • Bal MM, Deodhar K, Shrikhande S, Shukla P, Arya S, Ramadwar M (2013) Solid pseudopapillary tumor of the pancreas: ‚Experiences‘ and ‚Lessons‘ at a tertiary-care oncology center. Diagn Cytopathol 41(7): 599–606

    Article  PubMed  Google Scholar 

  • Bassi C, Sarr MG, Lillemoe KD, Reber HA (2008) Natural history of intraductal papillary mucinous neoplasms (IPMN): current evidence and implications for management. J Gastrointest Surg 12(4): 645–650

    Article  PubMed  Google Scholar 

  • Bhanot P, Nealon WH, Walser EM, Bhutani MS, Tang WW, Logrono R (2005) Clinical, imaging, and cytopathological features of solid pseudopapillary tumor of the pancreas: a clinicopathologic study of three cases and review of the literature. Diagn Cytopathol 33(6): 421–428

    Article  PubMed  Google Scholar 

  • Cai H, Zhou M, Hu Y, He H, Chen J, Tian W, Deng Y (2013) Solid-pseudopapillary neoplasms of the pancreas: clinical and pathological features of 33 cases. Surg Today 43(2): 148–154

    Article  PubMed  CAS  Google Scholar 

  • Chari ST, Yadav D, Smyrk TC, DiMagno EP, Miller LJ, Raimondo M, Clain JE, Norton IA, Pearson RK, Petersen BT, Wiersema MJ, Farnell MB, Sarr MG (2002) Study of recurrence after surgical resection of intraductal papillary mucinous neoplasm of the pancreas. Gastroenterology 123(5): 1500–1507

    Article  PubMed  Google Scholar 

  • Crippa S, Salvia R, Bassi C (2009) Development of ductal adenocarcinoma during follow-up of branch-duct IPMNs. Gut 58(6): 889–890

    PubMed  CAS  Google Scholar 

  • Crippa S, Salvia R, Warshaw AL, Dominguez I, Bassi C, Falconi M, Thayer SP, Zamboni G, Lauwers GY, Mino-Kenudson M, Capelli P, Pederzoli P, Castillo CF (2008) Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients. Ann Surg 247(4): 571–579

    Article  PubMed  Google Scholar 

  • Goh BK, Tan YM, Cheow PC, Chung AY, Chow PK, Wong WK, Ooi LL (2007) Solid pseudopapillary neoplasms of the pancreas: an updated experience. J Surg Oncol 95(8): 640–644

    Article  PubMed  Google Scholar 

  • Guo N, Zhou QB, Chen RF, Zou SQ, Li ZH, Lin Q, Wang J, Chen JS (2011) Diagnosis and surgical treatment of solid pseudopapillary neoplasm of the pancreas: analysis of 24 cases. Can J Surg 54(6): 368–374

    Article  PubMed  Google Scholar 

  • Honore C, Goere D, Dartigues P, Burtin P, Dumont F, Elias D (2012) Peritoneal carcinomatosis from solid pseudopapillary neoplasm (Frantz‘s tumour) of the pancreas treated with HIPEC. Anticancer Res 32(3): 1069–1073

    PubMed  CAS  Google Scholar 

  • Huang HL, Shih SC, Chang WH, Wang TE, Chen MJ, Chan YJ (2005) Solid-pseudopapillary tumor of the pancreas: clinical experience and literature review. World J Gastroenterol 11(9): 1403–1409

    PubMed  Google Scholar 

  • Kanter J, Wilson DB, Strasberg S (2009) Downsizing to resectability of a large solid and cystic papillary tumor of the pancreas by single-agent chemotherapy. J Pediatr Surg 44(10): e23–25

    Article  PubMed  Google Scholar 

  • Kaufman SL, Reddick RL, Stiegel M, Wild RE, Thomas CG Jr (1986) Papillary cystic neoplasm of the pancreas: a curable pancreatic tumor. World J Surg 10(5): 851–859

    Article  PubMed  CAS  Google Scholar 

  • Le Borgne J, de Calan L, Partensky C (1999) Cystadenomas and cystadenocarcinomas of the pancreas: a multiinstitutional retrospective study of 398 cases. French Surgical Association. Ann Surg 230(2): 152–161

    Article  PubMed  CAS  Google Scholar 

  • Li Z, Zhang Z, Liu X, Hu W, Mai G, Zhang Y, Lu H, Zeng Y, Tian B (2010) Solid pseudopapillary tumor of the pancreas: the surgical procedures. Surg Today 41(1): 91–96

    Article  PubMed  Google Scholar 

  • Mao C, Guvendi M, Domenico DR, Kim K, Thomford NR, Howard JM (1995) Papillary cystic and solid tumors of the pancreas: a pancreatic embryonic tumor? Studies of three cases and cumulative review of the world’s literature. Surgery 118(5): 821–828

    Article  PubMed  CAS  Google Scholar 

  • Martin RC, Klimstra DS, Brennan MF, Conlon KC (2002) Solid-pseudopapillary tumor of the pancreas: a surgical enigma? Ann Surg Oncol 9(1): 35–40

    Article  PubMed  Google Scholar 

  • Mimura T, Masuda A, Matsumoto I, Shiomi H, Yoshida S, Sugimoto M, Sanuki T, Yoshida M, Fujita T, Kutsumi H, Ku Y, Azuma T (2010) Predictors of malignant intraductal papillary mucinous neoplasm of the pancreas. J Clin Gastroenterol 44(9): e224–229

    Article  PubMed  Google Scholar 

  • Nakao A, Fernandez-Cruz L (2007) Pancreatic head resection with segmental duodenectomy: safety and long-term results. Ann Surg 246(6): 923–928; discussion 929–931

    Google Scholar 

  • Niedergethmann M, Grützmann R, Hildenbrand R, Dittert D, Aramin N, Franz M, Dobrowolski F, Post S, Saeger HD (2008) Outcome of invasive and noninvasive intraductal papillary-mucinous neoplasms of the pancreas (IPMN): a 10-year experience. World J Surg 32(10): 2253–2260

    Article  PubMed  Google Scholar 

  • Papavramidis T, Papavramidis S (2005) Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature. J Am Coll Surg 200(6): 965–972

    Article  PubMed  Google Scholar 

  • Rodriguez JR, Salvia R, Crippa S, Warshaw AL, Bassi C, Falconi M, Thayer SP, Lauwers GY, Capelli P, Mino-Kenudson M, Razo O, McGrath D, Pederzoli P, Fernandez-del Castillo C (2007) Branch-duct intraductal papillary mucinous neoplasms: observations in 145 patients who underwent resection. Gastroenterology 133(1): 72–79; quiz 309–310

    Google Scholar 

  • Sakorafas GH, Smyrniotis V, Reid-Lombardo KM, Sarr MG (2011) Primary pancreatic cystic neoplasms revisited: part II. Mucinous cystic neoplasms. Surg Oncol 20(2): e93–101

    Article  PubMed  Google Scholar 

  • Salvia R, Crippa S, Falconi M, Bassi C, Guarise A, Scarpa A, Pederzoli P (2007) Branch-duct intraductal papillary mucinous neoplasms of the pancreas: to operate or not to operate? Gut 56(8): 1086–1090

    Article  PubMed  Google Scholar 

  • Salvia R, Fernandez-del Castillo C, Bassi C, Thayer SP, Falconi M, Mantovani W, Pederzoli P, Warshaw AL (2004) Main-duct intraductal papillary mucinous neoplasms of the pancreas: clinical predictors of malignancy and long-term survival following resection. Ann Surg 239(5): 678–685; discussion 685–687

    Google Scholar 

  • Sarr MG, Carpenter HA, Prabhakar LP, Orchard TF, Hughes S, van Heerden JA, DiMagno EP (2000) Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas: can one reliably differentiate benign from malignant (or premalignant) neoplasms? Ann Surg 231(2): 205–212

    Article  PubMed  CAS  Google Scholar 

  • Sarr MG, Murr M, Smyrk TC, Yeo CJ, Fernandez-del-Castillo C, Hawes RH, Freeny PC (2003) Primary cystic neoplasms of the pancreas. Neoplastic disorders of emerging importance-current state-of-the-art and unanswered questions. J Gastrointest Surg 7(3): 417–428

    Article  PubMed  Google Scholar 

  • Sohn TA, Yeo CJ, Cameron JL, Hruban RH, Fukushima N, Campbell KA, Lillemoe KD (2004) Intraductal papillary mucinous neoplasms of the pancreas: an updated experience. Ann Surg 239(6): 788–797; discussion 797–799

    Google Scholar 

  • Sugiyama M, Izumisato Y, Abe N, Masaki T, Mori T, Atomi Y (2003) Predictive factors for malignancy in intraductal papillary-mucinous tumours of the pancreas. Br J Surg 90(10): 1244–1249

    Article  PubMed  CAS  Google Scholar 

  • Tanaka M, Chari S, Adsay V, Fernandez-del Castillo C, Falconi M, Shimizu M, Yamaguchi K, Yamao K, Matsuno S (2006) International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology 6(1–2): 17–32

    Article  PubMed  Google Scholar 

  • Tanaka M, Fernandez-del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, Kimura W, Levy P, Pitman MB, Schmidt CM, Shimizu M, Wolfgang CL, Yamaguchi K, Yamao K (2012) International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology 12(3): 183–197

    Article  PubMed  Google Scholar 

  • Tang LH, Aydin H, Brennan MF, Klimstra DS (2005) Clinically aggressive solid pseudopapillary tumors of the pancreas: a report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional cases. Am J Surg Pathol 29(4): 512–519

    Article  PubMed  Google Scholar 

  • Tipton SG, Smyrk TC, Sarr MG, Thompson GB (2006) Malignant potential of solid pseudopapillary neoplasm of the pancreas. Br J Surg 93(6): 733–737

    Article  PubMed  CAS  Google Scholar 

  • Traverso LW, Peralta EA, Ryan JA Jr, Kozarek RA (1998) Intraductal neoplasms of the pancreas. Am J Surg 175(5): 426–432

    Article  PubMed  CAS  Google Scholar 

  • Valsangkar NP, Morales-Oyarvide V, Thayer SP, Ferrone CR, Wargo JA, Warshaw AL, Fernandez-del Castillo C (2012) 851 resected cystic tumors of the pancreas: A 33-year experience at the Massachusetts General Hospital. Surgery 152(3 Suppl 1): S4–S12

    Article  PubMed  Google Scholar 

  • Vollmer CM Jr, Dixon E, Grant DR (2003) Management of a solid pseudopapillary tumor of the pancreas with liver metastases. HPB (Oxford) 5(4): 264–267

    Article  Google Scholar 

  • Wada K, Kozarek RA, Traverso LW (2005) Outcomes following resection of invasive and noninvasive intraductal papillary mucinous neoplasms of the pancreas. Am J Surg 189(5): 632–636; discussion 637

    Google Scholar 

  • Wang SE, Shyr YM, Chen TH, Su CH, Hwang TL, Jeng KS, Chen JH, Wu CW, Lui WY (2005) Comparison of resected and non-resected intraductal papillary mucinous neoplasms of the pancreas. World J Surg 29(12): 1650–1657

    Article  PubMed  Google Scholar 

  • Zamboni G, Scarpa A, Bogina G, Iacono C, Bassi C, Talamini G, Sessa F, Capella C, Solcia E, Rickaert F, Mariuzzi GM, Klöppel G (1999) Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. Am J Surg Pathol 23(4): 410–422

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Allgemein-, Viszeral- und Thoraxchirurgie, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Deutschland

    Florian Gebauer, Jakob R. Izbicki & Emre F. Yekebas

Authors
  1. Florian Gebauer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jakob R. Izbicki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Emre F. Yekebas
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Florian Gebauer .

Editor information

Editors and Affiliations

  1. Abt. Allgemeine- und Visceralchirurgie, Universitätsklinikum Ulm, Germany

    Hans G. Beger

  2. Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Heidelberg, Germany

    Markus W. Büchler

  3. Allgemein-, Viszeral- und Gefäßchirurgie, Universitätsklinikum Halle, Sachsen-Anhalt, Germany

    Henning Dralle

  4. Klinik und Poliklinik für Innere Medizin, Universitätsmedizin Greifswald, Germany

    Markus M. Lerch

  5. und Hepatologie (KGHI), Universitätsklinikum Magdeburg, Germany

    Peter Malfertheiner

  6. FB Gastroenterologie und Hepatologie, Universitätsklinikum Leipzig, Sachsen, Germany

    Joachim Mössner

  7. ehemals Klinikum der Stadt Ludwigshafen gGmbH, Rheinland-Pfalz, Germany

    Jürgen F. Riemann

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Gebauer, F., Izbicki, J., Yekebas, E. (2013). Langzeitverlauf nach Beobachtung und chirurgischer Therapie zystischer Pankreasneoplasien. In: Beger, H., et al. Erkrankungen des Pankreas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37964-2_60

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-37964-2_60

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37963-5

  • Online ISBN: 978-3-642-37964-2

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation