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Peniskarzinom

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Uroonkologie

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Zusammenfassung

Das Peniskarzinom ist das Plattenepithelkarzinom des Urogenitaltraktes. Aufgrund der oberflächlichen Lokalisation ist eine Diagnose im Frühstadium möglich, tatsächlich werden viele Fälle aufgrund patientenbedingter Faktoren erst in fortgeschrittenen Stadien festgestellt. Dieses urologische Malignom ist als streng lymphogen metastasierender Tumor in lokal begrenzten Stadien operativ heilbar. Die Prognose wird entscheidend vom Status und vom Management der inguinalen Lymphknoten bestimmt. Nicht selten wird aus Sorge vor den Konsequenzen der Behandlung von therapeutischen Standards abgewichen. Bei Progression ist mit systemischer Therapie eine Heilung nur in Ausnahmefällen möglich. Aufgrund der geringen Inzidenz handelt es sich um eine „orphan disease“, in deren Erforschung wenig Mittel investiert werden, und Therapiestudien sind rar. Die klinische Praxis ist oft gekennzeichnet durch individuelle Heilversuche mit häufig schlechten Ergebnissen.

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Literatur

  • Agrawal A, Pai D, Ananthakrishnan N, Smile SR, Ratnakar C. The histological extent of the local spread of carcinoma of the penis and its therapeutic implications. BJU Int (2000) 85: 299–301

    Article  CAS  PubMed  Google Scholar 

  • Austoni E, Fenice O, Kartalas Goumas Y, Colombo F, Mantovani F, Pisani E. (New trends in the surgical treatment of penile carcinoma). Arch Ital Urol Androl (1996) 68: 163–168

    Google Scholar 

  • Bermejo C, Busby JE, Spiess PE, Heller L, Pagliaro LC, Pettaway CA. Neoadjuvant chemotherapy followed by aggressive surgical consolidation for metastatic penile squamous cell carcinoma. J Urol (2007) 177: 1335–1338

    Article  PubMed  Google Scholar 

  • Bevan-Thomas R, Slaton JW, Pettaway CA. Contemporary morbidity from lymphadenectomy for penile squamous cell carcinoma: the M.D. Anderson Cancer Center Experience. J Urol (2002) 167: 1638–1642

    Article  PubMed  Google Scholar 

  • Bouchot O, Rigaud J, Maillet F, Hetet JF, Karam G. Morbidity of inguinal lymphadenectomy for invasive penile carcinoma. Eur Urol (2004) 45: 761–765; discussion 765–766

    Article  PubMed  Google Scholar 

  • Brinton LA, Li JY, Rong SD et al. Risk factors for penile cancer: results from a case-control study in China. Int J Cancer (1991) 47: 504–509

    Article  CAS  PubMed  Google Scholar 

  • Cabanas RM. An approach for the treatment of penile carcinoma. Cancer (1977) 39: 456–466

    Article  CAS  PubMed  Google Scholar 

  • Catalona WJ. Modified inguinal lymphadenectomy for carcinoma of the penis with preservation of saphenous veins: technique and preliminary results. J Urol (1988) 140: 306–310

    CAS  PubMed  Google Scholar 

  • Corral DA, Sella A, Pettaway CA, Amato RJ, Jones DM, Ellerhorst J. Combination chemotherapy for metastatic or locally advanced genitourinary squamous cell carcinoma: a phase II study of methotrexate, cisplatin and bleomycin. J Urol (1998) 160: 1770–1774

    Article  CAS  PubMed  Google Scholar 

  • Cubilla AL, Dillner J, Schellhammer PF, Horenblas S, Ayala AG, Reuter VE, Von Krogh G. Tumours of the penis. In: Eble JNSG, Epstein JI, Sesterhenn IA (eds) World Health Organization Classification of tumours Pathology and genetics of tumours of the urinary system and male genital organs Lyon, France: IARC Press, 2004: 280–290

    Google Scholar 

  • Cubilla AL, Reuter V, Velazquez E, Piris A, Saito S, Young RH. Histologic classification of penile carcinoma and its relation to outcome in 61 patients with primary resection. Int J Surg Pathol (2001) 9: 111–120

    Article  CAS  PubMed  Google Scholar 

  • Cubilla AL. The role of pathologic prognostic factors in squamous cell carcinoma of the penis. World J Urol (2009) 27: 169–177

    Article  PubMed  Google Scholar 

  • Daling JR, Madeleine MM, Johnson LG et al. Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease. Int J Cancer (2005) 116: 606–616

    Article  CAS  PubMed  Google Scholar 

  • Daseler EH, Anson BJ, Reimann AF. Radical excision of the inguinal and iliac lymph glands; a study based upon 450 anatomical dissections and upon supportive clinical observations. Surg Gynecol Obstet (1948) 87: 679–694

    CAS  PubMed  Google Scholar 

  • Dexeus FH, Logothetis CJ, Sella A et al. Combination chemotherapy with methotrexate, bleomycin and cisplatin for advanced squamous cell carcinoma of the male genital tract. J Urol (1991) 146: 1284–1287

    CAS  PubMed  Google Scholar 

  • Doeberitz MK, Vinokurova S. Host factors in HPV-related carcinogenesis: cellular mechanisms controlling HPV infections. Arch Med Res (2009) 40: 435–442

    Article  CAS  PubMed  Google Scholar 

  • Favorito LA, Nardi AC, Ronalsa M, Zequi SC, Sampaio FJ, Glina S. Epidemiologic study on penile cancer in Brazil. Int Braz J Urol (2008) 34: 587–591; discussion 591–583

    Article  PubMed  Google Scholar 

  • Franks KN, Kancherla K, Sethugavalar B, Whelan P, Eardley I, Kiltie AE. Radiotherapy for node positive penile cancer: experience of the Leeds teaching hospitals. J Urol. 2010 186: 524–529

    Article  Google Scholar 

  • Gonzaga-Silva LF, Tavares JM, Freitas FC, Tomas Filho ME, Oliveira VP, Lima MV. The isolated gamma probe technique for sentinel node penile carcinoma detection is unreliable. Int Braz J Urol (2007) 33: 58–63; discussion 64–57

    Article  PubMed  Google Scholar 

  • Haas GP, Blumenstein BA, Gagliano RG et al. Cisplatin, methotrexate and bleomycin for the treatment of carcinoma of the penis: a Southwest Oncology Group study. J Urol (1999) 161: 1823–1825

    Article  CAS  PubMed  Google Scholar 

  • Hakenberg OW, Nippgen JB, Froehner M, Zastrow S, Wirth MP. Cisplatin, methotrexate and bleomycin for treating advanced penile carcinoma. BJU Int (2006) 98: 1225–1227

    Article  CAS  PubMed  Google Scholar 

  • Harish K, Ravi R. The role of tobacco in penile carcinoma. Br J Urol (1995) 75: 375–377

    Article  CAS  PubMed  Google Scholar 

  • Hegarty PK, Shabbir M, Hughes B et al. Penile preserving surgery and surgical strategies to maximize penile form and function in penile cancer: recommendations from the United Kingdom experience. World J Urol (2009) 27: 179–187

    Article  PubMed  Google Scholar 

  • Hellberg D, Valentin J, Eklund T, Nilsson S. Penile cancer: is there an epidemiological role for smoking and sexual behaviour? Br Med J (Clin Res Ed) (1987) 295: 1306–1308

    Article  CAS  Google Scholar 

  • Hernandez BY, Barnholtz-Sloan J, German RR et al. Burden of invasive squamous cell carcinoma of the penis in the United States, 1998–2003. Cancer (2008) 113: 2883–2891

    Article  PubMed Central  PubMed  Google Scholar 

  • Hernandez-Toris N, Quintero-Becerra J, Gallegos-Hernandez JF et al. (Lymphatic mapping and sentinel node biopsy in penis cancer. Feasibility study and preliminary report). Cir Cir (2007) 75: 87–91

    Google Scholar 

  • Horenblas S, Jansen L, Meinhardt W, Hoefnagel CA, de Jong D, Nieweg OE. Detection of occult metastasis in squamous cell carcinoma of the penis using a dynamic sentinel node procedure. J Urol (2000) 163: 100–104

    Article  CAS  PubMed  Google Scholar 

  • Hussein AM, Benedetto P, Sridhar KS. Chemotherapy with cisplatin and 5-fluorouracil for penile and urethral squamous cell carcinomas. Cancer (1990) 65: 433438

    Article  Google Scholar 

  • Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin (2007) 57: 43–66

    Google Scholar 

  • Kroon BK, Horenblas S, Lont AP, Tanis PJ, Gallee MP, Nieweg OE. Patients with penile carcinoma benefit from immediate resection of clinically occult lymph node metastases. J Urol (2005) 173: 816–819

    Article  CAS  PubMed  Google Scholar 

  • Leijte JA, Gallee M, Antonini N, Horenblas S. Evaluation of current TNM classification of penile carcinoma. J Urol (2008) 180: 933–938; discussion 938

    Article  PubMed  Google Scholar 

  • Leijte JA, Kerst JM, Bais E, Antonini N, Horenblas S. Neoadjuvant chemotherapy in advanced penile carcinoma. Eur Urol (2007) 52: 488–494

    Article  CAS  PubMed  Google Scholar 

  • Leijte JA, Kirrander P, Antonini N, Windahl T, Horenblas S. Recurrence patterns of squamous cell carcinoma of the penis: recommendations for follow-up based on a two-centre analysis of 700 patients. Eur Urol (2008) 54: 161–168

    Article  PubMed  Google Scholar 

  • Leijte JA, Kroon BK, Valdes Olmos RA, Nieweg OE, Horenblas S. Reliability and safety of current dynamic sentinel node biopsy for penile carcinoma. Eur Urol (2007) 52: 170–177

    Article  PubMed  Google Scholar 

  • Leis PF, Stevens KR, Baer SC, Kadmon D, Goldberg LH, Wang XJ. A c-rasHa mutation in the metastasis of a human papillomavirus (HPV)-18 positive penile squamous cell carcinoma suggests a cooperative effect between HPV-18 and c-rasHa activation in malignant progression. Cancer (1998) 83: 122–129

    Article  CAS  PubMed  Google Scholar 

  • Lont AP, Gallee MP, Meinhardt W, van Tinteren H, Horenblas S. Penis conserving treatment for T1 and T2 penile carcinoma: clinical implications of a local recurrence. J Urol (2006) 176: 575–580; discussion 580

    Article  CAS  PubMed  Google Scholar 

  • Lont AP, Kroon BK, Gallee MP, van Tinteren H, Moonen LM, Horenblas S. Pelvic lymph node dissection for penile carcinoma: extent of inguinal lymph node involvement as an indicator for pelvic lymph node involvement and survival. J Urol (2007) 177: 947–952; discussion 952

    Article  PubMed  Google Scholar 

  • Madsen BS, van den Brule AJ, Jensen HL, Wohlfahrt J, Frisch M. Risk factors for squamous cell carcinoma of the penis – population-based case-control study in Denmark. Cancer Epidemiol Biomarkers Prev (2008) 17: 2683–2691

    Article  CAS  PubMed  Google Scholar 

  • Martins AC, Faria SM, Cologna AJ, Suaid HJ, Tucci S Jr. Immunoexpression of p53 protein and proliferating cell nuclear antigen in penile carcinoma. J Urol (2002) 167: 89–92; discussion 92–83

    Article  CAS  PubMed  Google Scholar 

  • Minhas S, Kayes O, Hegarty P, Kumar P, Freeman A, Ralph D. What surgical resection margins are required to achieve oncological control in men with primary penile cancer? BJU Int (2005) 96: 1040–1043

    Article  PubMed  Google Scholar 

  • Misra S, Chaturvedi A, Misra NC. Penile carcinoma: a challenge for the developing world. Lancet Oncol (2004) 5: 240–247

    Article  PubMed  Google Scholar 

  • Narayana AS, Olney LE, Loening SA, Weimar GW, Culp DA. Carcinoma of the penis: analysis of 219 cases. Cancer (1982) 49: 2185–2191

    Article  CAS  PubMed  Google Scholar 

  • Necchi A, Nicolai N, Colecchia M et al. Proof of activity of anti-epidermal growth factor receptor-targeted therapy for relapsed squamous cell carcinoma of the penis. J Clin Oncol. 2011 29: 650–652

    Article  Google Scholar 

  • Ornellas AA, Kinchin EW, Nobrega BL, Wisnescky A, Koifman N, Quirino R. Surgical treatment of invasive squamous cell carcinoma of the penis: Brazilian National Cancer Institute long-term experience. J Surg Oncol (2008) 97: 487–495

    Article  PubMed  Google Scholar 

  • Pagliaro LC, Williams DL, Daliani D et al. Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. J Clin Oncol. 2010 28: 3851–3857

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Parkin DM WS, Ferlay J, Teppo L, Thomas DB (ed). Cancer Incidence in Five Continents. IARC Scientific Publications No155 Lyon, France: IARC, 2002

    Google Scholar 

  • Persson B, Sjodin JG, Holmberg L, Windahl T. The National Penile Cancer Register in Sweden 2000–2003. Scand J Urol Nephrol (2007) 41: 278–282

    Article  PubMed  Google Scholar 

  • Pizzocaro G, Algaba F, Horenblas S et al. EAU Penile Cancer Guidelines 2009. Eur Urol

    Google Scholar 

  • Pizzocaro G, Nicolai N, Milani A. Taxanes in Combination with Cisplatin and Fluorouracil for Advanced Penile Cancer: Preliminary Results. Eur Urol. 2008

    Google Scholar 

  • Pizzocaro G, Piva L, Bandieramonte G, Tana S. Up-to-date management of carcinoma of the penis. Eur Urol (1997) 32: 5–15

    CAS  PubMed  Google Scholar 

  • Pizzocaro G, Piva L. Adjuvant and neoadjuvant vincristine, bleomycin, and methotrexate for inguinal metastases from squamous cell carcinoma of the penis. Acta Oncol (1988) 27: 823–824

    Article  CAS  PubMed  Google Scholar 

  • Poetsch M, Schuart BJ, Schwesinger G, Kleist B, Protzel C. Screening of microsatellite markers in penile cancer reveals differences between metastatic and nonmetastatic carcinomas. Mod Pathol (2007) 20: 1069–1077

    Article  CAS  PubMed  Google Scholar 

  • Poetsch M, Hemmerich M, Kakies C et al. Alterations in the tumor suppressor gene p16(INK4A) are associated with aggressive behavior of penile carcinomas. Virchows Arch (2011) 458: 221–229

    Article  CAS  PubMed  Google Scholar 

  • Protzel C, Alcaraz A, Horenblas S, Pizzocaro G, Zlotta A, Hakenberg OW. Lymphadenectomy in the surgical management of penile cancer. Eur Urol (2009) 55: 1075–1088

    Article  PubMed  Google Scholar 

  • Protzel C, Hakenberg OW. Chemotherapy in patients with penile carcinoma. Urol Int (2009) 82: 1–7

    Article  CAS  PubMed  Google Scholar 

  • Protzel C, Kakies C, Kleist B, Poetsch M, Giebel J. Down-regulation of the metastasis suppressor protein KAI1/CD82 correlates with occurrence of metastasis, prognosis and presence of HPV DNA in human penile squamous cell carcinoma. Virchows Arch (2008) 452: 369–375

    Article  CAS  PubMed  Google Scholar 

  • Ravi R. Morbidity following groin dissection for penile carcinoma. Br J Urol (1993) 72: 941–945

    Article  CAS  PubMed  Google Scholar 

  • Rubin MA, Kleter B, Zhou M et al. Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesis. Am J Pathol (2001) 159: 1211–1218

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Saisorn I, Lawrentschuk N, Leewansangtong S, Bolton DM. Fine-needle aspiration cytology predicts inguinal lymph node metastasis without antibiotic pretreatment in penile carcinoma. BJU Int (2006) 97: 1225–1228

    Article  PubMed  Google Scholar 

  • Sastre-Garau X, Favre M, Couturier J, Orth G. Distinct patterns of alteration of myc genes associated with integration of human papillomavirus type 16 or type 45 DNA in two genital tumours. J Gen Virol (2000) 81: 1983–1993

    CAS  PubMed  Google Scholar 

  • Schlenker B, Gratzke C, Seitz M et al. Fluorescence-guided laser therapy for penile carcinoma and precancerous lesions: Long-term follow-up. Urol Oncol. 2009

    Google Scholar 

  • Schlenker B, Tilki D, Seitz M et al. Organ-preserving neodymium-yttrium-aluminium-garnet laser therapy for penile carcinoma: a long-term follow-up. BJU Int. 2010 106: 786–790

    Article  PubMed  Google Scholar 

  • Sobin LH, Gospodariwicz M, Wittekind C (eds). TNM Classification of malignant tumours. UICC International Union Against Cancer, 7th edn. New York: Wiley-Blackwell 2009

    Google Scholar 

  • Theodore C, Skoneczna I, Bodrogi I et al. A phase II multicentre study of irinotecan (CPT 11) in combination with cisplatin (CDDP) in metastatic or locally advanced penile carcinoma (EORTC PROTOCOL 30992). Ann Oncol. 2008

    Google Scholar 

  • Velazquez EF, Barreto JE, Rodriguez I, Piris A, Cubilla AL. Limitations in the interpretation of biopsies in patients with penile squamous cell carcinoma. Int J Surg Pathol (2004) 12: 139–146

    Article  PubMed  Google Scholar 

  • Young R SJ, Amin M, Ulbright T, Cubilla A. Tumors of the prostate gland, seminal vesicles, male urethra and penis. In: Rosai J. SL, ed. Atlas of Tumor Pathology. Washington, D.C., USA: Armed Forces Institute of Pathology, 2000: 1–334

    Google Scholar 

  • Zhu Y, Li H, Yao XD et al. Feasibility and activity of sorafenib and sunitinib in advanced penile cancer: a preliminary report. Urol Int. 2010 85: 334–340

    Article  PubMed  Google Scholar 

  • zur Hausen H. Papillomaviruses in the causation of human cancers – a brief historical account. Virology (2009) 384: 260–265

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Urologische Klinik und Poliklinik, Universitätsklinikum Rostock, Ernst-Heydemann-Str. 6, D-18055, Rostock, Deutschland

    C. Protzel

  2. Urologische Klinik und Poliklinik, Universitätsklinikum Rostock, Ernst-Heydemann-Straße 6, D-18055, Rostock, Deutschland

    O.W. Hakenberg

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  1. Klinik und Poliklinik für Urologie, Universitätsklinikum Essen, Essen, Germany

    Herbert Rübben

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Protzel, C., Hakenberg, O. (2014). Peniskarzinom. In: Rübben, H. (eds) Uroonkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35032-0_26

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