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Genomic Basis of Breast Cancer

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Molecular Basis of Breast Cancer

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Abstract

The Human Genome Project (HGP) is having a significant impact on the way that we are studying the biology and pathology of breast cancer and in turn it will have a significant impact in the way that medicine will be practiced in this century. The final objective of the HGP is to identify the genes and their function as a physical unit of heredity that passes from parents to offspring. These pieces of DNA contain information for making specific protein that is the following challenge in our understanding of the biologic process under discussion. To find a gene, and its function it was first needed to define the DNA sequence that determines the gene and how many genes make up the human genome. Whereas approximately 3 billion DNA base pairs have been sequenced, only 3% of the human genome DNA is used to make proteins. Therefore, 97% of the human genome is in excess of DNA accumulated from viral infections, erroneous duplications, and other events. At the present time, it is not clear how many genes are contained in the 3 billion DNA bases.

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  1. Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA

    Jose Russo MD, FACP & Irma H. Russo MD, FACP

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Russo, J., Russo, I.H. (2004). Genomic Basis of Breast Cancer. In: Molecular Basis of Breast Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18736-0_8

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